Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Harnor SJ"'
Autor:
Matheson, CJ, Coxon, CR, Bayliss, R, Boxall, K, Carbain, B, Fry, AM, Hardcastle, IR, Harnor, SJ, Mas-Droux, C, Newell, DR, Richards, MW, Sivaprakasam, M, Turner, D, Griffin, RJ, Golding, BT, Cano, C
Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers. We now report the design, synthesis and biological evaluation of 6-ethynylpurines that ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::50079741394e01f4bd1b1137f16bfc2a
https://eprints.whiterose.ac.uk/160431/19/d0md00074d.pdf
https://eprints.whiterose.ac.uk/160431/19/d0md00074d.pdf
Autor:
Miller DC; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, United Kingdom., Harnor SJ; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, United Kingdom., Martin MP; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom., Noble RA; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom., Wedge SR; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom., Cano C; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, United Kingdom.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2023 Apr 13; Vol. 66 (7), pp. 4491-4502. Date of Electronic Publication: 2023 Apr 01.
Autor:
Gai C; Organic Chemistry Group, College of Pharmacy, Naval Medical University Shanghai 200433 P. R. China c.gai2@outlook.com., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University Newcastle upon Tyne NE1 7RU UK., Zhang S; Organic Chemistry Group, College of Pharmacy, Naval Medical University Shanghai 200433 P. R. China c.gai2@outlook.com., Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University Newcastle upon Tyne NE1 7RU UK., Zhuang C; Organic Chemistry Group, College of Pharmacy, Naval Medical University Shanghai 200433 P. R. China c.gai2@outlook.com., Zhao Q; Organic Chemistry Group, College of Pharmacy, Naval Medical University Shanghai 200433 P. R. China c.gai2@outlook.com.
Publikováno v:
RSC medicinal chemistry [RSC Med Chem] 2022 Oct 11; Vol. 13 (12), pp. 1460-1475. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2022).
Autor:
Miller DC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Reuillon T; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Molyneux L; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Blackburn T; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Edwards N; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Golding BT; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Hardcastle I; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Heptinstall A; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Lochhead P; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Martin MP; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Martin NC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Myers S; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Newell DR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Noble RA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Phillips N; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Rigoreau L; Cancer Research UK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Campus, Babraham, Cambridgeshire CB22 3AT, U.K., Thomas H; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Tucker JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Wang LZ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Waring MJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K., Wong AC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London NW1 0NH, U.K., Wedge SR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Noble MEM; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K., Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6513-6540. Date of Electronic Publication: 2022 Apr 25.
Autor:
Al-Khawaldeh I; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Al Yasiri MJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Aldred GG; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Basmadjian C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Bordoni C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Heptinstall AB; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Hobson SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Jennings CE; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Khalifa S; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Lebraud H; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Martin MP; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Miller DC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Shrives HJ, de Souza JV; Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Stewart HL; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Temple M; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Thomas HD; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Totobenazara J; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Tucker JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Tudhope SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Wang LZ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Bronowska AK; Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Golding BT; Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Hardcastle IR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Hickson I; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Wedge SR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Willmore E; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Noble MEM; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Waring MJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 10001-10018. Date of Electronic Publication: 2021 Jul 02.
Autor:
Chessari G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hardcastle IR; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Ahn JS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Anil B; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Anscombe E; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., Bawn RH; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Bevan LD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Blackburn TJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Buck I; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cano C; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Carbain B; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Castro J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cons B; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Cully SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Fazal L; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Golding BT; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Haggerty K; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Hearn K; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Hobson S; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Holvey RS; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Howard S; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Jennings CE; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Johnson CN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Lunec J; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Miller DC; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Newell DR; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Noble MEM; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Reeks J; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Revill CH; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Riedinger C; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K., St Denis JD; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Tamanini E; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Thomas H; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Thompson NT; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Vinković M; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wedge SR; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K., Williams PA; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Wilsher NE; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K., Zhang B; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Zhao Y; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O'Gorman Building, Newcastle upon Tyne NE2 4HH, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 4071-4088. Date of Electronic Publication: 2021 Mar 24.
Autor:
Matheson CJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Coxon CR; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Bayliss R; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK.; Section of Structural Biology , The Institute of Cancer Research , Sutton , UK., Boxall K; Cancer Research UK Cancer Therapeutics Unit , The Institute of Cancer Research , Sutton , UK., Carbain B; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Fry AM; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK., Hardcastle IR; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Harnor SJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Mas-Droux C; Section of Structural Biology , The Institute of Cancer Research , Sutton , UK., Newell DR; Cancer Research UK Newcastle Drug Discovery Unit , Translational and Clinical Research Institute , Newcastle University Centre for Cancer , Faculty of Medical Sciences , Newcastle University , Newcastle upon Tyne , UK., Richards MW; School of Molecular and Cellular Biology , The Astbury Centre for Structural Molecular Biology , University of Leeds , UK., Sivaprakasam M; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Turner D; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Griffin RJ; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Golding BT; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060., Cano C; Cancer Research UK Newcastle Drug Discovery Unit , Chemistry, School of Natural and Environmental Sciences , Newcastle University , Newcastle upon Tyne , UK . Email: celine.cano@ncl.ac.uk ; Tel: +44 (0)191 208 7060.
Publikováno v:
RSC medicinal chemistry [RSC Med Chem] 2020 May 22; Vol. 11 (6), pp. 707-731. Date of Electronic Publication: 2020 May 22 (Print Publication: 2020).
Autor:
Myers SM; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Miller DC; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Molyneux L; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Arasta M; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Bawn RH; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Blackburn TJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Edwards N; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Endicott JA; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Golding BT; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Griffin RJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Hammonds T; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK., Hardcastle IR; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Harnor SJ; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Heptinstall AB; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Lochhead PA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Martin MP; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Martin NC; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Newell DR; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Owen PJ; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK., Pang LC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK., Reuillon T; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Rigoreau LJM; Cancer Research UK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Campus, Babraham, Cambridgeshire, CB22 3AT, UK., Thomas HD; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Tucker JA; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Wang LZ; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Wong AC; Cancer Research UK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, 2 Royal College Street, London, NW1 0NH, UK., Noble MEM; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK. Electronic address: martin.noble@ncl.ac.uk., Wedge SR; Newcastle Drug Discovery, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK. Electronic address: steve.wedge@ncl.ac.uk., Cano C; Newcastle Drug Discovery, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK. Electronic address: celine.cano@ncl.ac.uk.
Publikováno v:
European journal of medicinal chemistry [Eur J Med Chem] 2019 Sep 15; Vol. 178, pp. 530-543. Date of Electronic Publication: 2019 May 25.
Autor:
Hill SL; National Institute for Health Research Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK; simon.hill@ncl.ac.uk michael.dunn3@ncl.ac.uk celine.cano@ncl.ac.uk., Dunn M; National Institute for Health Research Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK; simon.hill@ncl.ac.uk michael.dunn3@ncl.ac.uk celine.cano@ncl.ac.uk., Cano C; School of Chemistry, Newcastle University, Newcastle upon Tyne, UK.; simon.hill@ncl.ac.uk michael.dunn3@ncl.ac.uk celine.cano@ncl.ac.uk., Harnor SJ; School of Chemistry, Newcastle University, Newcastle upon Tyne, UK., Hardcastle IR; School of Chemistry, Newcastle University, Newcastle upon Tyne, UK., Grundlingh J; Emergency Department, Royal London Hospital, London, UK., Dargan PI; Clinical Toxicology, Guy's and St. Thomas' NHS Foundation Trust and Kings Health Partners, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Wood DM; Clinical Toxicology, Guy's and St. Thomas' NHS Foundation Trust and Kings Health Partners, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Tucker S; Emergency Department, Blackpool Victoria Hospital, Blackpool, UK., Bartram T; Emergency Department, Pennine Acute Hospital Trust, Royal Oldham Hospital, Oldham, UK., Thomas SHL; National Institute for Health Research Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK.
Publikováno v:
Clinical chemistry [Clin Chem] 2018 Feb; Vol. 64 (2), pp. 346-354. Date of Electronic Publication: 2017 Oct 16.