Enhancement of stem cell therapy after thoracic spinal cord injury by the administration of sonic hedgehog

Autor: Younsi, A, Zhang, H, Tail, M, Zheng, G, Harms, AK, Roth, J, Hatami, M, Skutella, T, Unterberg, AW, Zweckberger, K

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV263 /20200626/

Objective: Traumatic spinal cord injury (SCI) is a devastating event with limited functional recovery. As a potential treatment approach, neural precursor cell (NPC) transplantation has shown beneficial effects on neuroregeneration. However, survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc20068684fe3c242df3fc45ddb94f5

Sonic Hedgehog reduces inflammatory response, decreases blood-spinal cord barrier permeability, and improves locomotor function recovery in an acute spinal cord injury rat model.

Autor: Tail M; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany.; Department of Neurology, Heidelberg University Hospital, 69120, Heidelberg, Germany., Zhang H; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Zheng G; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Harms AK; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Hatami M; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, 69120, Heidelberg, Germany., Skutella T; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, 69120, Heidelberg, Germany., Kiening K; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Unterberg A; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Zweckberger K; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany., Younsi A; Department of Neurosurgery, Heidelberg University Hospital, 69120, Heidelberg, Germany. alexander.younsi@med.uni-heidelberg.de.

Publikováno v: Journal of inflammation (London, England) [J Inflamm (Lond)] 2024 Sep 03; Vol. 21 (1), pp. 34. Date of Electronic Publication: 2024 Sep 03.

Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion-compression model.

Autor: Zhang H; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Younsi A; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. alexander.younsi@med.uni-heidelberg.de., Zheng G; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Tail M; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Harms AK; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Roth J; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Hatami M; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120, Heidelberg, Germany., Skutella T; Department of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120, Heidelberg, Germany., Unterberg A; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany., Zweckberger K; Department of Neurosurgery, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

Publikováno v: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2021 Jun; Vol. 30 (6), pp. 1509-1520. Date of Electronic Publication: 2021 Mar 11.