Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Harmit S. Malik"'
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Autor:
Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucl
Externí odkaz:
https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
Autor:
Yu-Ying Phoebe Hsieh, Wanting Sun, Janet M Young, Robin Cheung, Deborah A Hogan, Ajai A Dandekar, Harmit S Malik
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002694 (2024)
Fungi and bacteria coexist in many polymicrobial communities, yet the molecular basis of their interactions remains poorly understood. Here, we show that the fungus Candida albicans sequesters essential magnesium ions from the bacterium Pseudomonas a
Externí odkaz:
https://doaj.org/article/2a21b5d9164a439aa58deebd1547c39b
Publikováno v:
eLife, Vol 12 (2023)
Many animal species employ sperm nuclear basic proteins (SNBPs) or protamines to package sperm genomes tightly. SNBPs vary across animal lineages and evolve rapidly in mammals. We used a phylogenomic approach to investigate SNBP diversification in Dr
Externí odkaz:
https://doaj.org/article/c566bda69831462eb5cfb6f682f086b1
Autor:
Ching-Ho Chang, Harmit S Malik
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009494 (2021)
Externí odkaz:
https://doaj.org/article/3668dea894d440cd8c0820cf16dc23fb
Autor:
Piero Lamelza, Janet M Young, Luke M Noble, Lews Caro, Arielle Isakharov, Meenakshi Palanisamy, Matthew V Rockman, Harmit S Malik, Michael Ailion
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008520 (2019)
Although most unicellular organisms reproduce asexually, most multicellular eukaryotes are obligately sexual. This implies that there are strong barriers that prevent the origin or maintenance of asexuality arising from an obligately sexual ancestor.
Externí odkaz:
https://doaj.org/article/3744df6ec82649c2bda135890a9f6d1c
Publikováno v:
bioRxiv
Myxovirus resistance proteins (MxA and MxB) are interferon-induced proteins that exert antiviral activity against a diverse range of RNA and DNA viruses. In primates, MxA has been shown to inhibit myxoviruses, bunyaviruses, and hepatitis B virus, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7046aea4bc523be31e7d9f269de542
https://europepmc.org/articles/PMC10312577/
https://europepmc.org/articles/PMC10312577/
Autor:
Rossana Colón-Thillet, Emily Hsieh, Laura Graf, Richard N McLaughlin, Janet M Young, Georg Kochs, Michael Emerman, Harmit S Malik
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000181 (2019)
Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenes
Externí odkaz:
https://doaj.org/article/17900a824db4486098fa966658ecc257
Autor:
Lauren A Richardson, Sandra L Schmid, Avinash Bhandoola, Christelle Harly, Anders Hedenström, Michael T Laub, Georgina M Mace, Piali Sengupta, Ann M Stock, Andrew F Read, Harmit S Malik, Mark Estelle, Sally Lowell, Jonathan Kimmelman
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000180 (2019)
Externí odkaz:
https://doaj.org/article/fa32077ec61c4145bffd2f19ee04d3af