A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Autor: Jennifer Chu, Annelise De Carvalho, Bernard Masereel, Robert Kiss, Céline Meinguet, Guy Vandenbussche, Johan Wouters, Véronique Mathieu, Alexander Kornienko, Jerry Pelletier

Publikováno v: Carvalho, A, Chu, J, Meinguet, C, Kiss, R, Vandenbussche, G, Masereel, B, Wouters, J, Kornienko, A, Pelletier, J & Mathieu, V 2017, ' A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis ', European Journal of Pharmacology, vol. 805, pp. 25-35 . https://doi.org/10.1016/j.ejphar.2017.03.034

Growing evidence indicates that protein synthesis is deregulated in cancer onset and progression and targeting this process might be a selective way to combat cancers. While harmine is known to inhibit DYRK1A and intercalate into the DNA, tri-substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8222dd162259798b461077c3cdb9a71
https://doi.org/10.1016/j.ejphar.2017.03.034