Výsledky vyhledávání - "Harmesh Aojula"

Akademický článek

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

Autor: Izzeddin Alsalahat, Zubida M. Al-Majdoub, Mutasem O. Taha, Jill Barber, Harmesh Aojula, Nigel Hodson, Sally Freeman

Publikováno v: Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100943- (2021)

The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic benzylpenicillin (BP) can specifically bind to Aβ, modulate the process of aggregation a

Externí odkaz: https://doaj.org/article/2b65d79699e9452e8c0e4c4c4b236517

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Akademický článek

The influence of Tat-derived peptide (Tat-LK15) on the uptake of membrane p- glycoproteins substrate (Calcein AM)

Autor: Myasar Alkotaji, Alain Pluen, Harmesh Aojula

Publikováno v: المجلة العراقية للصيدلة, Vol 16, Iss 1, Pp 1-21 (2019)

Introduction: Cell penetrating peptides (CPPs) have been used in many areas of drug delivery for mediating the delivery of peptides, protein, DNA, siRNA and liposomes. Additionally they have shown an ability to overcome drug resistance in cells and e

Externí odkaz: https://doaj.org/article/b4fca30f4bce48989def579d04f2c921

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Akademický článek

Differential effects of NSAIDs on amyloid β1-42 peptide aggregation

Autor: Atheer Al-Zurfi, Harmesh Aojula, Jeffrey Penny

Publikováno v: British Journal of Pharmacy, Vol 4, Iss 1 (2019)

Alzheimer’s disease (AD) is the most common cause of dementia and one of the great health-care challenges of the 21st century. The disease is characterised by extracellular aggregation of the amyloid beta (Aβ1-42) peptide within the brain, with su

Externí odkaz: https://doaj.org/article/5ea6e5b64ad140ee8ab2042780f49059

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Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

Autor: Sally Freeman, Izzeddin Alsalahat, Sarmad Al-Edresi, Jeffrey Penny, Harmesh Aojula

Publikováno v: Neurobiology of Aging. 94:24-33

Aggregation of amyloid β1–42 (Aβ1–42) peptide within the brain is considered one of the main causes of the neuropathological changes associated with Alzheimer's disease. Resveratrol is a well-known antioxidant but has also been reported to bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::193f94ef402c17ab90be812ec3f1c51e
https://doi.org/10.1016/j.neurobiolaging.2020.04.012

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'Bind, cleave and leave': multiple turnover catalysis of RNA cleavage by bulge-loop inducing supramolecular conjugates

Autor: Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova

Publikováno v: Nucleic Acids Research
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273

Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many copies of eme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7b808fe6bedc0a0aab05633989d108
https://pubmed.ncbi.nlm.nih.gov/34967410

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The influence of Tat-derived peptide (Tat-LK15) on the uptake of membrane p- glycoproteins substrate (Calcein AM)

Autor: Harmesh Aojula, Alain Pluen, Myasar Alkotaji

Publikováno v: Iraqi Journal of Pharmacy. 16:1-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4219025adede0b9237f313d36cf0894
https://doi.org/10.33899/iphr.2019.165706

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Microfluidic-assisted fabrication of phosphatidylcholine-based liposomes for controlled drug delivery of chemotherapeutics

Autor: Leonidas Gkionis, Lynda K. Harris, Annalisa Tirella, Harmesh Aojula

Publikováno v: International journal of pharmaceutics. 604

Microfluidic enables precise control over the continuous mixing of fluid phases at the micrometre scale, aiming to optimize the processing parameters and to facilitate scale-up feasibility. The optimization of parameters to obtain monodispersed drug-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0143ffc2e1f5a4b3c2bc5d9b29cd51
https://pubmed.ncbi.nlm.nih.gov/34015381

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Manufacturing drug co-loaded liposomal formulations targeting breast cancer: influence of preparative method on liposomes characteristics and in vitro toxicity

Autor: Harmesh Aojula, Richard A. Campbell, Annalisa Tirella, Lynda K. Harris, Leonidas Gkionis

Publikováno v: Gkionis, L, Campbell, R A, Aojula, H, Harris, L K & Tirella, A 2020, ' Manufacturing drug co-loaded liposomal formulations targeting breast cancer: influence of preparative method on liposomes characteristics and in vitro toxicity ', International Journal of Pharmaceutics, vol. 590, 119926 . https://doi.org/10.1016/j.ijpharm.2020.119926

Developing more efficient manufacturing methods for nano therapeutic systems is becoming important, not only to better control their physico-chemical characteristics and therapeutic efficacy but also to ensure scale-up is cost-effective. The principl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacfeb67900047eca56b5773ba702e02
https://pure.manchester.ac.uk/ws/files/176705312/Gkionis_Manuscript_Liposomes_Revision_ACCEPTED_002_.docx

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