Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Harmen J.G. Van de Werken"'
Autor:
Boris J.B. Beudeker, Zgjim Osmani, Gertine W. van Oord, Zwier M.A. Groothuismink, Robert J. de Knegt, Remco M. Hoogenboezem, Eric M.J. Bindels, Harmen J.G. van de Werken, Andre Boonstra
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100980- (2024)
Background & Aims: HBsAg secretion may impact immune responses to chronic HBV infection. Thus, therapeutic approaches to suppress HBsAg production are being investigated. Our study aims to examine the immunomodulatory effects of high and low levels o
Externí odkaz:
https://doaj.org/article/542efaeae0b24074ae10f0b1e8f00943
Autor:
Barbara Rentroia-Pacheco, Selin Tokez, Edo M. Bramer, Zoe C. Venables, Harmen J.G. van de Werken, Domenico Bellomo, David van Klaveren, Antien L. Mooyaart, Loes M. Hollestein, Marlies Wakkee
Publikováno v:
EClinicalMedicine, Vol 63, Iss , Pp 102150- (2023)
Summary: Background: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, affecting more than 2 million people worldwide yearly and metastasising in 2–5% of patients. However, current clinical staging systems do not provide estimates o
Externí odkaz:
https://doaj.org/article/5c3c9ba20bcf412bb28d2d5305289726
Autor:
Wesley S. van de Geer, Ron H.J. Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, Lot A. Devriese, Vivianne C.G. Tjan-Heijnen, Emile E. Voest, Stefan Sleijfer, John W.M. Martens, Edwin Cuppen, Harmen J.G. van de Werken, Sander Bins
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114210- (2023)
Drug resistance is a perpetual problem in cancer therapy with many underlying mechanisms. Alterations in drug transport over the cancer cell membrane can severely alter intratumoral drug exposure, contributing to resistance. Here, we present the soma
Externí odkaz:
https://doaj.org/article/dfde034a6bb040089d45cdf4f8ef6c58
Autor:
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogen
Externí odkaz:
https://doaj.org/article/c51dcad216b44704bc99e3de44c2cf7a
Autor:
Adone Mohd-Sarip, Miriam Teeuwssen, Alice G. Bot, Maria J. De Herdt, Stefan M. Willems, Robert J. Baatenburg de Jong, Leendert H.J. Looijenga, Diana Zatreanu, Karel Bezstarosti, Job van Riet, Edwin Oole, Wilfred F.J. van Ijcken, Harmen J.G. van de Werken, Jeroen A. Demmers, Riccardo Fodde, C. Peter Verrijzer
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 61-75 (2017)
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell c
Externí odkaz:
https://doaj.org/article/388a23c8a0fc482fa04851442525be89
Autor:
Malou van den Boogaard, Jan Hendrik van Weerd, Amira C. Bawazeer, Ingeborg B. Hooijkaas, Harmen J.G. van de Werken, Federico Tessadori, Wouter de Laat, Phil Barnett, Jeroen Bakkers, Vincent M. Christoffels
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2704-2714.e5 (2019)
Summary: The human ether-a-go-go-related gene KCNH2 encodes the voltage-gated potassium channel underlying IKr, a current critical for the repolarization phase of the cardiac action potential. Mutations in KCNH2 that cause a reduction of the repolari
Externí odkaz:
https://doaj.org/article/f23e46c627da422ab766f3b9dde3a0a8
Autor:
Dorota Kurek, Alex Neagu, Melodi Tastemel, Nesrin Tüysüz, Johannes Lehmann, Harmen J.G. van de Werken, Sjaak Philipsen, Reinier van der Linden, Alex Maas, Wilfred F.J. van IJcken, Micha Drukker, Derk ten Berge
Publikováno v:
Stem Cell Reports, Vol 4, Iss 1, Pp 114-128 (2015)
Summary: Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer B
Externí odkaz:
https://doaj.org/article/3c19380446b64edaa65eff3bcfdb80e5
Autor:
Ron Smits, Qiuwei Pan, Marco Bruno, Maikel P. Peppelenbosch, Marla Lavrijsen, Wanlu Cao, Marieke van der Heide, Harmen J.G. van de Werken, Kostandinos Sideras, Pengyu Liu, Shan Li, Wenhui Wang
Aberrant activation of Wnt/β-catenin signaling plays a key role in the onset and development of hepatocellular carcinomas (HCC), with about half of them acquiring mutations in either CTNNB1 or AXIN1. The serine/threonine kinase receptor-associated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::717ed5f664228ae443ca95621a0b96d9
https://doi.org/10.1158/1541-7786.c.6540210.v1
https://doi.org/10.1158/1541-7786.c.6540210.v1
Autor:
Ron Smits, Qiuwei Pan, Marco Bruno, Maikel P. Peppelenbosch, Marla Lavrijsen, Wanlu Cao, Marieke van der Heide, Harmen J.G. van de Werken, Kostandinos Sideras, Pengyu Liu, Shan Li, Wenhui Wang
S1. Specificity of STRAP antibody tested on a STRAP knock-out Huh6 clone and control thereof. S2. Knockout of the STRAP gene by CRISPR/Cas9 technology in HCC cell lines. S3. Elevated expression of STRAP in DEN-induced mouse liver tumors (T) compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e167f819a8bce840f2dd280bb8b6d71
https://doi.org/10.1158/1541-7786.22512318.v1
https://doi.org/10.1158/1541-7786.22512318.v1
Autor:
Dik C. van Gent, Agnes Jager, John W.M. Martens, Roland Kanaar, Harmen J.G. van de Werken, Marcel Smid, Petra M. Nederlof, Esther Lips, Winand N.M. Dinjens, T. Dorine den Toom, Hendrikus-Jan Dubbink, Hein F.B.M. Sleddens, Michael A. den Bakker, Carolien H.M. van Deurzen, Kishan A.T. Naipal, Job van Riet, Anieta M. Sieuwerts, Nicole S. Verkaik, Titia G. Meijer
BRCA1 promoter hypermethylation and RNA in situ hybridization by RNAscope. M248, M253, M112 and M232 clearly showed presence of BRCA1 RNA, whereas in M94 (BRCA1 deletion) no BRCA1 RNA was present. M131 and M277 showed heterogeneous presence of BRCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2827c3e4bd4d34908bd75437d10a77c8
https://doi.org/10.1158/1078-0432.22467974
https://doi.org/10.1158/1078-0432.22467974