Výsledky vyhledávání - "Harmeen K. Deol"

High‐Resolution NMR H/D Exchange of Human Superoxide Dismutase Inclusion Bodies Reveals Significant Native Features Despite Structural Heterogeneity

Autor: Dalia Naser, Michael V. Tarasca, Bruna Siebeneichler, Anna Schaefer, Harmeen K. Deol, Tyler G. B. Soule, Johnathan Almey, Susan Kelso, Gyana G. Mishra, Hilary Simon, Elizabeth M. Meiering

Publikováno v: Angewandte Chemie International Edition. 61

Protein aggregation is central to aging, disease and biotechnology. While there has been recent progress in defining structural features of cellular protein aggregates, many aspects remain unclear due to heterogeneity of aggregates presenting obstacl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111fbd285e9c0ef965d593e69533f398
https://doi.org/10.1002/anie.202112645

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Immature ALS-associated mutant superoxide dismutases form variable aggregate structures through distinct oligomerization processes

Autor: Harmeen K, Deol, Helen R, Broom, Bruna, Siebeneichler, Brenda, Lee, Zoya, Leonenko, Elizabeth M, Meiering

Publikováno v: Biophysical Chemistry. 288:106844

Protein misfolding and aggregation are hallmarks of many diseases, including amyotrophic lateral sclerosis (ALS). In familial ALS, aberrant self-association of mutant Cu,Zn-superoxide dismutase (SOD1) is implicated as a key contributor to disease. Mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a11f9dbf54f6424b84e51e0ecfc5f26
https://doi.org/10.1016/j.bpc.2022.106844

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