Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Harma, Ellens"'
Autor:
Joe, Bentz, Harma, Ellens
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
In the first edition of this book, we presented the basics of explicitly incorporating the lipid biochemistry into a confluent cell monolayer transport model and the novel findings of this model up to 2013, including the use of global optimization to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2ae5189f6d4f186c7d41dd2d0129a7f
https://pubmed.ncbi.nlm.nih.gov/34272715
https://pubmed.ncbi.nlm.nih.gov/34272715
Autor:
Joe Bentz, Harma Ellens
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
In the first edition of this book, we presented the basics of explicitly incorporating the lipid biochemistry into a confluent cell monolayer transport model and the novel findings of this model up to 2013, including the use of global optimization to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf941b1bec2f1dec263ca450a1220ce
https://doi.org/10.1007/978-1-0716-1554-6_27
https://doi.org/10.1007/978-1-0716-1554-6_27
Autor:
Annie Albin Lumen, Libin Li, Jiben Li, Zeba Ahmed, Zhou Meng, Albert Owen, Harma Ellens, Ismael J Hidalgo, Joe Bentz
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69394 (2013)
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as measured in the presence of GF120918) to achieve the observed efflux kinetics across MDCK-
Externí odkaz:
https://doaj.org/article/14700a32b0ad4e079adfa32cc63b0b32
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 14:571-584
In vitro transporter kinetics are typically analyzed by steady-state Michaelis-Menten approximations. However, no clear evidence exists that these approximations, applied to multiple transporters in biological membranes, yield system-independent mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a52139554d5afc71ed10e4808b64e7e
https://doi.org/10.1080/17425255.2018.1480720
https://doi.org/10.1080/17425255.2018.1480720
Autor:
Harma Ellens, Maciej J. Zamek-Gliszczynski, Mitesh Patel, Marta Johnson, Caroline Sychterz, Gareth J. Lewis, Joseph W. Polli, Cory A Watson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:37-45
Atovaquone, an antiprotozoal and antipneumocystic agent, is predominantly cleared by biliary excretion of unchanged parent drug. Atovaquone is ≥10,000-fold concentrated in human bile relative to unbound plasma. Even after correcting for apparent no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d3c7d17df8690608b18392c303cec5
https://doi.org/10.1124/jpet.117.247254
https://doi.org/10.1124/jpet.117.247254
Autor:
Git Chung, Colin D.A. Brown, Joe Bentz, Akshata Yalvigi, Caroline Lee, Michael O'Connor, Adam Lynn, Harma Ellens, Aqsaa Chaudhry
Publikováno v:
Drug Metabolism and Disposition. 46:279-290
It has been previously demonstrated that IC50 values for inhibition of digoxin transport across confluent polarized cell monolayers are system-dependent. Digoxin IC50 data from five laboratories participating in the P-glycoprotein (P-gp) IC50 Initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ade2ecaf40d6d7a551308a028b43ea
https://doi.org/10.1124/dmd.117.075606
https://doi.org/10.1124/dmd.117.075606
Autor:
Deep Agnani, Poulomi Acharya, Esteban Martinez, Thuy Thanh Tran, Feby Abraham, Frank Tobin, Harma Ellens, Joe Bentz
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25086 (2011)
P-glycoprotein, a human multidrug resistance transporter, has been extensively studied due to its importance to human health and disease. In order to understand transport kinetics via P-gp, confluent cell monolayers overexpressing P-gp are widely use
Externí odkaz:
https://doaj.org/article/47857b4ef5ac49acabc1af6846470038
Publikováno v:
Drug Metabolism and Disposition. 45:145-151
From fits of drug transport kinetics across confluent MDCKII-hMDR1-NKI and Caco-2 cell monolayers we estimated the levels of efflux active P-glycoprotein (P-gp) in these two cell lines (companion paper). In the present work, we compared the efflux ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602c64bcc0d298d99a812ee9ef9a32ed
https://doi.org/10.1124/dmd.116.072157
https://doi.org/10.1124/dmd.116.072157
Publikováno v:
Drug Metabolism and Disposition. 45:27-34
Rosuvastatin is a widely prescribed antihyperlipidemic which undergoes limited metabolism, but is an in vitro substrate of multiple transporters [organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, OATP2B1, sodium-taurocholate cot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d71167e70cb2e1ab5b90ebdc2df707e
https://doi.org/10.1124/dmd.116.072397
https://doi.org/10.1124/dmd.116.072397
Autor:
Harma Ellens, Mary F. Paine, Maciej J. Zamek-Gliszczynski, Jack Cook, Caroline A. Lee, Mitchell E. Taub, Tasha K. Ritchie, Joseph A. Ware, Bo Feng, Meeghan A O'Connor, Aleksandra Galetin, Isabelle Ragueneau-Majlessi, Joseph W. Polli
Publikováno v:
Drug Metabolism and Disposition. 43:490-509
Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-permeability substrate drugs and mediates biliary excretion of drugs and metabolites. Based on clinical evidence of BCRP-mediated drug-drug interactions (DDIs) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a06f6950d0467683ba7779ef8a23e0
https://doi.org/10.1124/dmd.114.062174
https://doi.org/10.1124/dmd.114.062174