Zobrazeno 1 - 10
of 24
pro vyhledávání: '"HarmJan Vos"'
Autor:
Miguel Hernández-Quiles, Laura Martinez Campesino, Imogen Morris, Zabran Ilyas, Steve Reynolds, Nguan Soon Tan, Paula Sobrevals Alcaraz, Edwin C.A. Stigter, Ákos Varga, János Varga, Robert van Es, Harmjan Vos, Heather L. Wilson, Endre Kiss-Toth, Eric Kalkhoven
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101829- (2023)
Objective: In vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if
Externí odkaz:
https://doaj.org/article/f125550a747e4a01a5443dc366d1888f
Autor:
Mao‐Jie Wang, Huan‐Jie Huang, Yong‐Yue Xu, Harmjan Vos, Can Gulersonmez, Edwin Stigter, Johan Gerritsen, Marc Pages Gallego, Robert vanEs, Li Li, Hao Deng, Lin Han, Run‐Yue Huang, Chuan‐Jian Lu, Boudewijn MT Burgering
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp n/a-n/a (2023)
Abstract Besides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in thei
Externí odkaz:
https://doaj.org/article/09c566b0f11b4620ab617fd9addd2d55
Autor:
Sandra Tavares, Nalan Liv, Milena Pasolli, Mark Opdam, Max A.K. Rätze, Manuel Saornil, Lilian M. Sluimer, Rutger C.C. Hengeveld, Robert van Es, Erik van Werkhoven, Harmjan Vos, Holger Rehmann, Boudewijn M.T. Burgering, Hendrika M. Oosterkamp, Susanne M.A. Lens, Judith Klumperman, Sabine C. Linn, Patrick W.B. Derksen
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110584- (2022)
Summary: Elevated expression of non-receptor tyrosine kinase FER is an independent prognosticator that correlates with poor survival of high-grade and basal/triple-negative breast cancer (TNBC) patients. Here, we show that high FER levels are also as
Externí odkaz:
https://doaj.org/article/9434a26e702a448687ec52764f334902
Autor:
Alexandra Milona, Vittoria Massafra, Harmjan Vos, Jyoti Naik, Natalia Artigas, Helen A.B. Paterson, Ingrid T.G.W. Bijsmans, Ellen C.L. Willemsen, Jose M. Ramos Pittol, Irene Miguel-Aliaga, Piter Bosma, Boudewijn M.T. Burgering, Catherine Williamson, Santiago Vernia, Waljit S. Dhillo, Saskia W.C. van Mil, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 221-229 (2019)
Objective: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. Methods and results: Here, we show that in the liver
Externí odkaz:
https://doaj.org/article/f03fe7de90804886b4db2443d1f7e1c8
Autor:
Miguel Hernández-Quiles, Rosalie Baak, Alba Orea-Soufi, Anouska Borgman, Suzanne den Haan, Paula Sobrevals Alcaraz, Aldo Jongejan, Robert van Es, Guillermo Velasco, Harmjan Vos, Eric Kalkhoven
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10535 (2022)
Aberrant expression or activity of proteins are amongst the best understood mechanisms that can drive cancer initiation and progression, as well as therapy resistance. TRIB3, a member of the Tribbles family of pseudokinases, is often dysregulated in
Externí odkaz:
https://doaj.org/article/3b2578dc01714bc8b1382b1cd1bc1c0d
Autor:
Miguel Hernández-Quiles, Rosalie Baak, Anouska Borgman, Suzanne den Haan, Paula Sobrevals Alcaraz, Robert van Es, Endre Kiss-Toth, Harmjan Vos, Eric Kalkhoven
Publikováno v:
Cancers, Vol 13, Iss 24, p 6318 (2021)
The three human Tribbles (TRIB) pseudokinases have been implicated in a plethora of signaling and metabolic processes linked to cancer initiation and progression and can potentially be used as biomarkers of disease and prognosis. While their modes of
Externí odkaz:
https://doaj.org/article/53033f3300814fdeb3d0309484fb3679
Autor:
Maria P, Clemente-Olivo, Miguel, Hernández-Quiles, Rinske, Sparrius, Miesje M, van der Stoel, Vera, Janssen, Jayron, Habibe, Janny, van den Burg, Aldo, Jongejan, Paula Sobrevals, Alcaraz, Robert, van Es, Harmjan, Vos, Eric, Kalkhoven, Carlie J M, de Vries
Publikováno v:
Cellular Signalling. 104:110587
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with t
Autor:
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew Ramstead, Sophia M. Hochrein, HarmJan Vos, Geert Geeven, Adeolu Adegoke, Anna Hoekstra, Robert van Es, José Ramos Pittol, Sebastiaan Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin Anderson, Ryan O'Connell, Martin Vaeth, John Ussher, Boudewijn Burgering, Paul Coffer
Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that generation of extra-mitochondrial pyruva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b71b2a137c6e61ad219ab6d4149ac04
https://doi.org/10.21203/rs.3.rs-1324599/v1
https://doi.org/10.21203/rs.3.rs-1324599/v1
Autor:
Mao-Jie Wang, Yong-Yue Xu, HarmJan Vos, Can Gulersonmez, Edwin Stigter, Johan Gerritsen, Marc Pages Gallego, Robert van Es, Li Li, Hao Deng, Ling Han, Run-Yue Huang, Chuan-Jian Lu, Boudewijn MT Burgering
Psoriasis is characterized by a combination of keratinocyte hyperproliferation and immune cell activation. Immune cell activation requires increased glucose consumption, consequently limiting glucose availability for other cell types like keratinocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b62c1471c98dc443f5ce9725bbc1e5
https://doi.org/10.1101/2022.01.21.477183
https://doi.org/10.1101/2022.01.21.477183
Autor:
Hsin-Yi, Huang, Saskia, Houwing, Lucas J T, Kaaij, Amanda, Meppelink, Stefan, Redl, Sharon, Gauci, Harmjan, Vos, Bruce W, Draper, Cecilia B, Moens, Boudewijn M, Burgering, Peter, Ladurner, Jeroen, Krijgsveld, Eugene, Berezikov, René F, Ketting
Publikováno v:
The EMBO journal. 30(16)
Piwi proteins function in an RNAi-like pathway that silences transposons. Piwi-associated RNAs, also known as piRNAs, act as a guide to identify Piwi targets. The tudor domain-containing protein Tdrd1 has been linked to this pathway but its function