Výsledky vyhledávání - "Harm T Jansen"

Feasibility of SPECT-CT imaging to study the pharmacokinetics of antisense oligonucleotides in a mouse model of Duchenne muscular dystrophy

Autor: Katia Donato, Peter C de Visser, Maria L. H. Vlaming, Rick Vermue, Begoña Aguilera, Raffaella Rossin, Evita van de Steeg, Daan Muilwijk, José W.A. van der Hoorn, Harm T. Jansen, Tilman Läppchen

Publikováno v: Nucleic Acid Therapeutics, 4, 27, 221-231

Antisense oligonucleotides (AONs) are promising candidates for treatment of Duchenne muscular dystrophy (DMD), a severe and progressive disease resulting in premature death. However, more knowledge on the pharmacokinetics of new AON drug candidates i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353c2a0bd3017f37368ccb03e1ce44ad
http://resolver.tudelft.nl/uuid:69f24d6e-b03d-4e05-ac81-8dac4d8771e3

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Combined Analysis of Pharmacokinetic and Efficacy Data of Preclinical Studies with Statins Markedly Improves Translation of Drug Efficacy to Human Trials

Autor: E. van de Steeg, W van Duyvenvoorde, Harm T. Jansen, Heleen M. Wortelboer, Robert Kleemann, Jeroen DeGroot, E.H. Offerman

Publikováno v: Journal of Pharmacology and Experimental Therapeutics, 3, 347, 635-644

Correct prediction of human pharmacokinetics (PK) and the safety and efficacy of novel compounds based on preclinical data, is essential but often fails. In the current study, we aimed to improve the predictive value of ApoE*3Leiden (E3L) trans-genic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ee9c172499fde77f9f29b5690d897a
https://doi.org/10.1124/jpet.113.208595

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A single oral dose of a polyglucosamine influences the bioavailability of [9-14C]-Oleic acid in adult female Göttingen minipigs

Autor: Marleen A. Hemmes, Nicole H. P. Cnubben, Dimitri Grossouw, Bert T. H. J. de Bie, Astrid Langenkamp-Brand, Shanti L. Tel, Harm T. Jansen

Publikováno v: BMC obesity

Background Worldwide obesity has nearly doubled since 1980 and is a leading risk for global deaths, profoundly affecting morbidity, mortality, health-care costs, and professional and personal quality of life. Treatment of obesity and its consequences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de978045964a0b0d59d499758758a687
https://doi.org/10.1186/s40608-016-0096-2

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N-3 Long-Chain Polyunsaturated Fatty Acids Prevent Excessive Fat Deposition in Adulthood in a Mouse Model of Postnatal Nutritional Programming

Autor: D. Kegler, Eline M. van der Beek, Bert J. M. van de Heijning, Harm T Jansen, Annemarie Oosting, Günther Boehm

Publikováno v: Pediatric Research. 68:494-499

This study investigates whether improved quality of nutrients during early postnatal life has effects on adult metabolic profile and body composition in a murine model of nutritional programming. Male offspring of C57Bl/6j dams received a diet contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6dd696d2884f60c25456bf3752f973
https://doi.org/10.1203/pdr.0b013e3181f74940

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PET-CT imaging with [(18)F]-gefitinib to measure Abcb1a/1b (P-gp) and Abcg2 (Bcrp1) mediated drug-drug interactions at the murine blood-brain barrier

Autor: Oliver C. Steinbach, Andy van Driel, Maria L. H. Vlaming, Jeroen DeGroot, Harm T. Jansen, Charles Frederik Sio, Tilman Läppchen, José W.A. van der Hoorn, Evita van de Steeg, Suzanne Kivits

Publikováno v: Nuclear medicine and biology. 42(11)

Introduction: The efflux transporters P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) are expressed at the blood-brain barrier (BBB), and can limit the access of a wide range of drugs to the brain. In this study we dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4b48a4979bcbc087409bde471e15f0
https://pubmed.ncbi.nlm.nih.gov/26264927

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Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3

Autor: E. van de Steeg, Harm T. Jansen, J. DeGroot, Maria L. H. Vlaming, Heleen M. Wortelboer, J. Venhorst, Irene Nooijen

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 70

Human organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are important hepatic uptake transporters. Early assessment of OATP1B1/1B3-mediated drug-drug interactions (DDIs) is therefore important for successful drug development. A promisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d233ca1976556cbc29dadd5607793ee0
https://pubmed.ncbi.nlm.nih.gov/25603031

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Feasibility of a 3D human airway epithelial model to study respiratory absorption

Autor: C. Frieke Kuper, Astrid A. Reus, Harm T. Jansen, Jos van Triel, Yvonne C.M. Staal, Wilfred J. M. Maas, Samuel Constant

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 28(2)

The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4603a5f6cc52b0d999a73ef2fd19a
https://pubmed.ncbi.nlm.nih.gov/24216300

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