Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Harm Maarsingh"'
Autor:
Seungkirl Ahn, Harm Maarsingh, Julia K.L. Walker, Samuel Liu, Akhil Hegde, Hyeje C. Sumajit, Alem W. Kahsai, Robert J. Lefkowitz
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Asthma is a chronic inflammatory disease associated with episodic airway narrowing. Inhaled β2-adrenergic receptor (β2AR) agonists (β2-agonists) promote — with limited efficacy — bronchodilation in asthma. All β2-agonists are canonical orthos
Externí odkaz:
https://doaj.org/article/7baee4fa0bf4499f85b0ab428028efe2
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs), which all utilize L-arginine as substrate. The production of NO in the lung and airways can play a number of roles during lung development, regulates airway and v
Externí odkaz:
https://doaj.org/article/03e7bdb58bdc4a6d9640c485148f9cf6
Autor:
Hoeke A. Baarsma, Bing Han, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Harm Maarsingh, Martina Schmidt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruc
Externí odkaz:
https://doaj.org/article/2689a820502b4991a3bb1673a2f9baab
Autor:
Harm Maarsingh, Anouk Oldenburger, Bing Han, Annet B. Zuidhof, Carolina R. S. Elzinga, Wim Timens, Herman Meurs, Ramadan B. Sopi, Martina Schmidt
Publikováno v:
Cells, Vol 10, Iss 5, p 1237 (2021)
Expression of bronchodilatory β2-adrenoceptors and bronchoconstrictive muscarinic M3-receptors alter with airway size. In COPD, (a combination of) β2-agonists and muscarinic M3-antagonists (anticholinergics) are used as bronchodilators. We studied
Externí odkaz:
https://doaj.org/article/5703f517814b4c94aeb70d034ab10194
Autor:
Haoxiao Zuo, Marina Trombetta-Lima, Irene H. Heijink, Christina H. T. J. van der Veen, Laura Hesse, Klaas Nico Faber, Wilfred J. Poppinga, Harm Maarsingh, Viacheslav O. Nikolaev, Martina Schmidt
Publikováno v:
Cells, Vol 9, Iss 2, p 356 (2020)
Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-kin
Externí odkaz:
https://doaj.org/article/9214b914e148402f9ef01cfa0983330b
Publikováno v:
Pharmaceuticals, Vol 5, Iss 12, Pp 1291-1331 (2012)
Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD). Characteristics of COPD are airway obs
Externí odkaz:
https://doaj.org/article/7880d2c1eda54689b11b6f654ca22e0b
Autor:
Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65580 (2013)
Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood. A possible player i
Externí odkaz:
https://doaj.org/article/054f34fd3c7a4061b407e60f6dc9d9a1
Autor:
Anouk Oldenburger, Sara S Roscioni, Esther Jansen, Mark H Menzen, Andrew J Halayko, Wim Timens, Herman Meurs, Harm Maarsingh, Martina Schmidt
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31574 (2012)
Cigarette smoke-induced release of pro-inflammatory cytokines including interleukin-8 (IL-8) from inflammatory as well as structural cells in the airways, including airway smooth muscle (ASM) cells, may contribute to the development of chronic obstru
Externí odkaz:
https://doaj.org/article/3b434a48b4934d42bf269ed0dc428148
Autor:
Harm Maarsingh, Kayla Oyler, Gamukama Tuhaise, Mariette Sourial, Adwoa O. Nornoo, Wambazu Moses, Laura A. Rhodes
Publikováno v:
Frontiers in Health Services. 2
BackgroundThe efficiency of the patient care process of short-term medical service trips is often not assessed. The Gregory School of Pharmacy has organized annual medical camps in rural Uganda, however, the paper health records used for documentatio