Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Harm H Kampinga"'
Autor:
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink
Publikováno v:
eLife, Vol 11 (2022)
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer. A loss of ATM is also associated with increased p
Externí odkaz:
https://doaj.org/article/856b7f3066a9420b8c72ca00c91ef1e2
Autor:
Maria Azkanaz, Aida Rodríguez López, Bauke de Boer, Wouter Huiting, Pierre-Olivier Angrand, Edo Vellenga, Harm H Kampinga, Steven Bergink, Joost HA Martens, Jan Jacob Schuringa, Vincent van den Boom
Publikováno v:
eLife, Vol 8 (2019)
Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various
Externí odkaz:
https://doaj.org/article/7ef9f9f5c08640258df51b6bb08ffa53
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract DNAJB6b is a molecular chaperone of the heat shock protein network, shown to play a crucial role in preventing aggregation of several disease-related intrinsically disordered proteins. Using homology modeling and microsecond-long all-atom mo
Externí odkaz:
https://doaj.org/article/1218db2543ba4e7e993401a17d3081c0
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126761 (2015)
HSPB5 (also called αB-crystallin) is a ubiquitously expressed small heat shock protein. Mutations in HSPB5 have been found to cause cataract, but are also associated with a subgroup of myofibrillar myopathies. Cells expressing each of these HSPB5 mu
Externí odkaz:
https://doaj.org/article/e826ff61f2594cd1b984e38e7b4f16a1
Autor:
Roelien A M Meijering, Marit Wiersma, Denise M S van Marion, Deli Zhang, Femke Hoogstra-Berends, Anne-Jan Dijkhuis, Martina Schmidt, Thomas Wieland, Harm H Kampinga, Robert H Henning, Bianca J J M Brundel
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133553 (2015)
The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness. Cells that fail to activate or maintain this protective response are
Externí odkaz:
https://doaj.org/article/2fbf7db494df495a9a7686a920c847bd
Autor:
Willianne I M Vonk, Vaishali Kakkar, Paulina Bartuzi, Dick Jaarsma, Ruud Berger, Marten H Hofker, Leo W J Klomp, Cisca Wijmenga, Harm H Kampinga, Bart van de Sluis
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92408 (2014)
The Copper Metabolism MURR1 domain protein 1 (COMMD1) is a protein involved in multiple cellular pathways, including copper homeostasis, NF-κB and hypoxia signalling. Acting as a scaffold protein, COMMD1 mediates the levels, stability and proteolysi
Externí odkaz:
https://doaj.org/article/4cda9e3091094d0296a52e3bdaa2dc0b
Autor:
Maarten Niemantsverdriet, Peter Nagle, Roland K Chiu, Johannes A Langendijk, Harm H Kampinga, Robert P Coppes
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50815 (2012)
The p53 homolog p73 is frequently overexpressed in cancers. Especially the transactivation domain truncated isoform ΔNp73 has oncogenic properties and its upregulation is associated with poor patient survival. It has been shown that ΔNp73 has an in
Externí odkaz:
https://doaj.org/article/038c591b4fc64e53a97a2385facebd2b
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16828 (2011)
A homozygous disruption or genetic mutation of the bag3 gene causes progressive myofibrillar myopathy in mouse and human skeletal and cardiac muscle disorder while mutations in the small heat shock protein αB-crystallin gene (CRYAB) are reported to
Externí odkaz:
https://doaj.org/article/e2813979c9364eeab68b89b71f2579b4
Autor:
Lei Ke, Roelien A M Meijering, Femke Hoogstra-Berends, Katarina Mackovicova, Michel J Vos, Isabelle C Van Gelder, Robert H Henning, Harm H Kampinga, Bianca J J M Brundel
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20395 (2011)
BackgroundWe previously demonstrated the small heat shock protein, HSPB1, to prevent tachycardia remodeling in in vitro and in vivo models for Atrial Fibrillation (AF). To gain insight into its mechanism of action, we examined the protective effect o
Externí odkaz:
https://doaj.org/article/7ceac7bc851f4a02b6f29f6b85772222
Autor:
Isabelle M A Lombaert, Jeanette F Brunsting, Pieter K Wierenga, Hette Faber, Monique A Stokman, Tineke Kok, Willy H Visser, Harm H Kampinga, Gerald de Haan, Robert P Coppes
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2063 (2008)
Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new cancer cases each year. Despite relatively high survival rates, the quality of life of these patients is severely compromised because of radiation-induced impairm
Externí odkaz:
https://doaj.org/article/4d68ea1539214538979a0670e4ea5049