Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH

Autor: Toshner, Mark, Church, Colin, Harbaum, Lars, Rhodes, Christopher, Villar Moreschi, Sofia S, Liley, James, Jones, Rowena, Arora, Amit, Batai, Ken, Desai, Ankit A, Coghlan, John G, Gibbs, J Simon R, Gor, Dee, Gräf, Stefan, Harlow, Louise, Hernandez-Sanchez, Jules, Howard, Luke S, Humbert, Marc, Karnes, Jason, Kiely, David G, Kittles, Rick, Knightbridge, Emily, Lam, Brian, Lutz, Katie A, Nichols, William C, Pauciulo, Michael W, Pepke-Zaba, Joanna, Suntharalingam, Jay, Soubrier, Florent, Trembath, Richard C, Schwantes-An, Tae-Hwi L, Wort, S John, Wilkins, Martin, Gaine, Sean, Morrell, Nicholas W, Corris, Paul A

Inflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension. Compelling preclinical data supports the therapeutic blockade of interleukin-6 signalling.We conducted an open-label phase-II study of intrave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e659b4ac01b268a9288bf0772ed0bb

Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension

Autor: Swietlik, Emilia Maria, Ruggiero, Alessandro, Fletcher, Andrew J, Taboada, Dolores, Knightbridge, Emily, Harlow, Louise, Harvey, Ian, Screaton, Nicholas, Cannon, John E, Sheares, Karen KK, Ng, Choo, Jenkins, David P, Pepke-Zaba, Joanna, Toshner, Mark R

There is a current debate surrounding how to classify patients with pulmonary hypertension. The chronic thromboembolic disease is an important area of unmet need with no current treatments. We describe the first prospective cohort of patients and cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33150ecf401086b4987ec3cd23f28e6b
https://www.repository.cam.ac.uk/handle/1810/286649

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Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension.

Autor: Swietlik EM; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Dept of Medicine, Cambridge, UK.; University of Warmia and Mazury, Olsztyn, Poland., Ruggiero A; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Fletcher AJ; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Taboada D; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Knightbridge E; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Harlow L; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Harvey I; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Screaton N; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Cannon JE; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Sheares KKK; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Ng C; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Jenkins DP; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Pepke-Zaba J; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Toshner MR; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Dept of Medicine, Cambridge, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2019 Jan 17; Vol. 53 (1). Date of Electronic Publication: 2019 Jan 17 (Print Publication: 2019).