Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Harley I. Kornblum"'
Autor:
Alireza Sohrabi, Austin E.Y.T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113175- (2023)
Summary: The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this
Externí odkaz:
https://doaj.org/article/d2250eca7fe7426383653643a3dc60db
Autor:
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to p
Externí odkaz:
https://doaj.org/article/2f813af486a84bc6939ddacebcf2e7f8
Autor:
Jiwen Li, Lin Pan, William G. Pembroke, Jessica E. Rexach, Marlesa I. Godoy, Michael C. Condro, Alvaro G. Alvarado, Mineli Harteni, Yen-Wei Chen, Linsey Stiles, Angela Y. Chen, Ina B. Wanner, Xia Yang, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum, Ye Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hyp
Externí odkaz:
https://doaj.org/article/80da4dfa224845c2a806b159e42df65d
Autor:
Kecheng Lei, Xiaoxia Gu, Alvaro G. Alvarado, Yuhong Du, Shilin Luo, Eun Hee Ahn, Seong Su Kang, Bing Ji, Xia Liu, Hui Mao, Haian Fu, Harley I. Kornblum, Lingjing Jin, Hua Li, Keqiang Ye
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-21 (2020)
Abstract Background Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upreg
Externí odkaz:
https://doaj.org/article/25ab2eba2ce34f0bb9e12d46df9f8c43
Autor:
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109957- (2021)
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodies
Externí odkaz:
https://doaj.org/article/8516b7196aa84c49af33aefb9f94a103
Autor:
Jantzen Sperry, Michael C. Condro, Lea Guo, Daniel Braas, Nathan Vanderveer-Harris, Kristen K.O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather Christofk, Maria G. Castro, Pedro R. Lowenstein, Janel E. Le Belle, Harley I. Kornblum
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101453- (2020)
Summary: Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in
Externí odkaz:
https://doaj.org/article/c408bc708ce74fd297a8a89e0dcb76f3
Autor:
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola, Harley I. Kornblum
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enz
Externí odkaz:
https://doaj.org/article/642fab9d621f45ce80bff09ea33cbe6b
Autor:
Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
Externí odkaz:
https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-2 (2019)
Externí odkaz:
https://doaj.org/article/99ec20d50a17417781e8a2f337eff5de
Autor:
Janel E. Le Belle, Jantzen Sperry, Amy Ngo, Yasmin Ghochani, Dan R. Laks, Manuel López-Aranda, Alcino J. Silva, Harley I. Kornblum
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 725-734 (2014)
A period of mild brain overgrowth with an unknown etiology has been identified as one of the most common phenotypes in autism. Here, we test the hypothesis that maternal inflammation during critical periods of embryonic development can cause brain ov
Externí odkaz:
https://doaj.org/article/42395dca1d2448a78b8616704b74c65f