Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harlequin mouse"'
Autor:
Miguel Fernández-de la Torre, Carmen Fiuza-Luces, Pedro L. Valenzuela, Sara Laine-Menéndez, Joaquín Arenas, Miguel A. Martín, Doug M. Turnbull, Alejandro Lucia, María Morán
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
AimCerebellar neurodegeneration is a main phenotypic manifestation of mitochondrial disorders caused by apoptosis-inducing factor (AIF) deficiency. We assessed the effects of an exercise training intervention at the cerebellum and brain level in a mo
Externí odkaz:
https://doaj.org/article/ba6d80a1687e4c84820f3663f5fc8568
Autor:
Morán, Miguel Fernández de la Torre, Carmen Fiuza-Luces, Sara Laine-Menéndez, Aitor Delmiro, Joaquín Arenas, Miguel Ángel Martín, Alejandro Lucia, María
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10973
By means of a proteomic approach, we assessed the pathways involved in cerebellar neurodegeneration in a mouse model (Harlequin, Hq) of mitochondrial disorder. A differential proteomic profile study (iTRAQ) was performed in cerebellum homogenates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b960792836526a30ecb76a47180130bb
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dolinar, Eric
Publikováno v:
Electronic Thesis and Dissertation Repository
Retinal diseases are personally debilitating and expensive, yet many early disease mechanisms leading to their onset and progression remain poorly understood. The harlequin mouse is a model of human mitochondrial dysfunction and parainflammation lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1548::34ed579720a6ad7556d1cc01cd01bea5
https://ir.lib.uwo.ca/etd/2156
https://ir.lib.uwo.ca/etd/2156
Autor:
Prtenjaca, Anita
Publikováno v:
Electronic Thesis and Dissertation Repository
Canadian population demographics are shifting to an increase in aged individuals and an increase in the prevalence of neurodegenerative diseases. The post-mitotic nature of most neurons highlights the need to understand the etiology and early mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1548::04290de7afb590256d4c45853353e738
https://ir.lib.uwo.ca/context/etd/article/2326/viewcontent/AP_PhD_Thesis_Jan_7.pdf
https://ir.lib.uwo.ca/context/etd/article/2326/viewcontent/AP_PhD_Thesis_Jan_7.pdf
Autor:
Mayers, Justin G
Publikováno v:
Electronic Thesis and Dissertation Repository
The prevalence of aging-related retinal degenerative disorders is rising amongst human populations and the origins and early mechanisms of retinal disease remain poorly understood. A model of premature aging, the harlequin mouse, was used to test the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1548::7f31432c46bb909dd98041ee94ef5b5d
https://ir.lib.uwo.ca/context/etd/article/2017/viewcontent/28.pdf
https://ir.lib.uwo.ca/context/etd/article/2017/viewcontent/28.pdf
Autor:
Crabbe, Rory A.
Publikováno v:
Digitized Theses
The harlequin (hq)/Big Blue® mouse, a novel model of oxidative stress- induced heart disease with transgene targets for assay of in vivo mutations, was used to assess the effects of elevated reactive oxygen species (ROS) on mutagenesis in the heart.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1548::7f47bc74ccbab1c2254cc542bd939042
https://ir.lib.uwo.ca/context/digitizedtheses/article/7848/viewcontent/2023_03_01_Monitoring_Mutations_In_Conditions_of_Oxidative_Stress_OCR__2_.pdf
https://ir.lib.uwo.ca/context/digitizedtheses/article/7848/viewcontent/2023_03_01_Monitoring_Mutations_In_Conditions_of_Oxidative_Stress_OCR__2_.pdf
Autor:
LARSON, JON SCOTT
Multicellular organisms are mosaic in nature because of genetic alterations that occur in somatic cells. There are many factors that can contribute to the formation of such alterations including aberrant DNA repair, environmental insults, epigenetic
Externí odkaz:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1163452507