Výsledky vyhledávání - "Harleen, Khurana"

Akademický článek

Preclinical Evaluation of a Potential GSH Ester Based PET/SPECT Imaging Probe DT(GSHMe)₂ to Detect Gamma Glutamyl Transferase Over Expressing Tumors.

Autor: Harleen Khurana, Virendra Kumar Meena, Surbhi Prakash, Krishna Chuttani, Nidhi Chadha, Ambika Jaswal, Devinder Kumar Dhawan, Anil Kumar Mishra, Puja Panwar Hazari

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134281 (2015)

Gamma Glutamyl Transferase (GGT) is an important biomarker in malignant cancers. The redox processes ensuing from GGT-mediated metabolism of extracellular GSH are implicated in critical aspects of tumor cell biology. Reportedly, Glutathione monoethyl

Externí odkaz: https://doaj.org/article/96682e9fda45492db28a4a0ae154769f

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Identification of diphenyl furan derivatives via high throughput and computational studies as ArgA inhibitors of Mycobacterium tuberculosis

Autor: Mitul Srivastava, Tushar Kanti Maiti, Raniki Kumari, Tannu Priya Gosain, Ramandeep Singh, Harleen Khurana, Chad E. Stephens, Andrew C. Bean, Deepika Chaudhary, Shailendra Asthana, Saurabh Chugh

Publikováno v: International journal of biological macromolecules. 193

Microbial amino acid biosynthetic pathways are underexploited for the development of anti-bacterial agents. N-acetyl glutamate synthase (ArgA) catalyses the first committed step in L-arginine biosynthesis and is essential for M. tuberculosis growth.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aeee6030f6db6e27c63baac7afdea0
https://pubmed.ncbi.nlm.nih.gov/34762917

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Radioprotective efficacy of GSH based peptidomimetic complex of manganese against radiation induced damage: DT(GS)2Mn(II)

Autor: Anil K. Mishra, Harleen Khurana, Puja Panwar Hazari

Publikováno v: Free Radical Biology and Medicine. 145:161-174

The adverse effects of ionizing radiation (IR) on biological tissues are mediated via increased production of reactive oxygen species (ROS) often resulting in life-threatening injuries. The effects of ionizing radiation on cells include the formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::030e3c66bc27bb19ffc6192c96213e61
https://doi.org/10.1016/j.freeradbiomed.2019.09.023

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Radioprotective efficacy of GSH based peptidomimetic complex of manganese against radiation induced damage: DT(GS)

Autor: Harleen, Khurana, Puja Panwar, Hazari, Anil Kumar, Mishra

Publikováno v: Free radical biologymedicine. 145

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfd1ba5301cc71b789d095ef5f021456
https://pubmed.ncbi.nlm.nih.gov/31550530

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Biotinidase Resistant 68Gallium-Radioligand Based on Biotin/Avidin Interaction for Pretargeting: Synthesis and Preclinical Evaluation

Autor: Ambika Jaswal, Harleen Khurana, Puja Panwar Hazari, Shrikant Kukreti, Virendra Kumar Meena, Surbhi Prakash, Anil K. Mishra

Publikováno v: Bioconjugate Chemistry. 27:2780-2790

A new macrocyclic system 2,2′-(12-amino-11,13-dioxo-1,4,7,10-tetraazacyclotridecane-4,7-diyl)diacetic acid (ATRIDAT) was designed for coordinating metals in +2 and +3 oxidation states particularly 68Ga(III), for PET imaging. ATRIDAT was conjugated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73f6b63740b639fea26aab6df008951a
https://doi.org/10.1021/acs.bioconjchem.6b00576

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Biotinidase Resistant

Autor: Surbhi, Prakash, Puja Panwar, Hazari, Virendra Kumar, Meena, Ambika, Jaswal, Harleen, Khurana, Shrikant, Kukreti, Anil Kumar, Mishra

Publikováno v: Bioconjugate chemistry. 27(11)

A new macrocyclic system 2,2'-(12-amino-11,13-dioxo-1,4,7,10-tetraazacyclotridecane-4,7-diyl)diacetic acid (ATRIDAT) was designed for coordinating metals in +2 and +3 oxidation states particularly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc70aa2ac0301b9ff7273e59ca3b7056
https://pubmed.ncbi.nlm.nih.gov/27723977

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LAT1 targeted delivery of methionine based imaging probe derived from M(III) metal ions for early diagnosis of proliferating tumours using molecular imaging modalities

Autor: Harleen Khurana, Surbhi Prakash, Anil K. Mishra, Puja Panwar Hazari, Ambika Jaswal, Surabhi Kirti Mishra, Hemanth Kumar Bhonsle, Virendra Kumar Meena, Lokendra Singh

Publikováno v: Current cancer drug targets. 14(9)

We investigated the potential of DTPA-bis(Methionine), a target specific amino acid based probe for detection of L-type amino acid transporters (LAT1) known to over express in proliferating tumours using multimodality imaging. The ligand, DTPA-bis(Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6512066111d6442d23a37cf8bc22b6
https://pubmed.ncbi.nlm.nih.gov/25329672

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A homodimeric bivalent radioligand derived from 1-(2-methoxyphenyl)piperazine with high affinity for in vivo 5-HT1A receptor imaging

Autor: Surbhi Prakash, Harish Chandra, Krishna Chuttani, Harleen Khurana, Puja Panwar Hazari, Niraj Singh, Anil K. Mishra

Publikováno v: MedChemComm. 3:814

The bivalent ligand approach is very promising and can give rise to molecular probes with enhanced conformational flexibility for tissue selective modulation. In this study we describe the synthesis of a homodimeric 5-HT1A receptor ligand by incorpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dee0d004a73d52231fbe5f123f4f4a58
https://doi.org/10.1039/c2md20062g

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