Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Harlan W. Cole"'
Autor:
Richard W. Zink, John G. Luz, Xiaoping Ruan, Milan Maletic, Thomas Edward Mabry, Matthew W. Carson, David K. Clawson, Nancy June Snyder, Michael J. Coghlan, A. Pustilnik, Chen Suen, Mary D. Adrian, Harlan W. Cole, Chahrzad Montrose, Daniel Timothy Kohlman, Brad Condon, Christine C. Cheng
Publikováno v:
Journal of medicinal chemistry. 57(3)
The structural basis of the pharmacology enabling the use of glucocorticoids as reliable treatments for inflammation and autoimmune diseases has been augmented with a new group of glucocorticoid receptor (GR) ligands. Compound 10, the archetype of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e0493a3fab96dd384d92ca38639224
https://pubmed.ncbi.nlm.nih.gov/24446728
https://pubmed.ncbi.nlm.nih.gov/24446728
Autor:
Andrew L. Glasebrook, Lorri L. Short, Harlan W. Cole, Ellen R. Rowley, James P. Sluka, David Lynn Phillips, Venugopalan M, Fuson Tr, Magee David Edward, Lewis D. Pennington, Na N. Yang, Masahiko Sato, Adrian, Timothy Alan Grese, Henry Uhlman Bryant, Pamela K. Shetler
Publikováno v:
Journal of Medicinal Chemistry. 41:1272-1283
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. In vivo structure-activity relationships and molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d5c642a524dc3cabeb566fedaf2674
https://doi.org/10.1021/jm970688z
https://doi.org/10.1021/jm970688z
Autor:
Andrews L. Glasebrook, Pam K. Shetler, D. Lynn Phillips, Lorri L. Short, Magee David Edward, Harlan W. Cole, Henry Uhlman Bryant, Timothy Alan Grese
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2683-2686
The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addcd08e6e1b37705fcd10382a39cc2a
https://doi.org/10.1016/s0960-894x(96)00502-1
https://doi.org/10.1016/s0960-894x(96)00502-1
Autor:
Magee David Edward, Masahiko Sato, James P. Sluka, Timothy Alan Grese, Henry Uhlman Bryant, John Kim, Ellen R. Rowley, Harlan W. Cole
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:903-908
Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::290044bf4f517b655708578ecc76f3f2
https://doi.org/10.1016/0960-894x(96)00141-2
https://doi.org/10.1016/0960-894x(96)00141-2
Autor:
Andrew L. Glasebrook, Lorri L. Short, Timothy Alan Grese, Ellen R. Rowley, Stephen Sung Yong Cho, D. Lynn Phillips, Magee David Edward, Harlan W. Cole, Henry Uhlman Bryant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:201-206
A series of 2-alkyl and 2-cycloalkyl raloxifene analogs have been prepared and evaluated in both in vitro and in vivo models of estrogen/antiestrogen activity. In particular, the 2-cyclohexyl analogs show promise as potent selective estrogen-receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4219f5508c1394d0226d3d8c3a2e82a
https://doi.org/10.1016/0960-894x(95)00575-e
https://doi.org/10.1016/0960-894x(95)00575-e
Autor:
Ellen R. Rowley, Henry Uhlman Bryant, Sung-Yong Stephen Cho, Harlan W. Cole, Lorri L. Short, Timothy Alan Grese, David Lynn Phillips, Andrew L. Glasebrook, Magee David Edward
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c251bbc649414a4d72226546a47bcd
https://doi.org/10.1002/chin.199621114
https://doi.org/10.1002/chin.199621114
Publikováno v:
Clinical Immunology and Immunopathology. 55:109-119
We previously reported that treatments with human recombinant interleukin-1β (rIL-1β) in DBA 1 mice which were suboptimally immunized with native chick type II collagen (NcII) markedly accelerated the onset of collagen-induced arthritis (CIA). In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9b1eae11931e45698404a08a24a3fc
https://doi.org/10.1016/0090-1229(90)90072-x
https://doi.org/10.1016/0090-1229(90)90072-x
Autor:
Jennifer Hoover, Qingqiang Zeng, Wei Yao, Allen Schmidt, Webster S. S. Jee, Masahiko Sato, Harlan W. Cole, Henry Uhlman Bryant, Yanfei L. Ma
Publikováno v:
Endocrinology. 144(5)
With the ready availability of several osteoporosis therapies, teriparatide [human PTH-(1-34)] is likely to be prescribed to postmenopausal women with prior exposure to agents that prevent bone loss, such as bisphosphonates, estrogen, or selective es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d97180581845a4579e529eb161c5c7
https://pubmed.ncbi.nlm.nih.gov/12697709
https://pubmed.ncbi.nlm.nih.gov/12697709
Autor:
Nancy L. Ostrowski, Binhui Ni, Steven M. Paul, Xin Wu, Yuan Su, Michele Glinn, Henry Uhlman Bryant, Harlan W. Cole
Publikováno v:
Brain research. 847(1)
Selective estrogen receptor modulators (SERMs) demonstrate tissue-specific estrogen receptor (ER) agonist or antagonist properties. Raloxifene, a prototypical SERM, has ER agonist properties in bone and on cholesterol metabolism but full antagonist p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5eb4a163b13e6df32c381176196c8a
https://pubmed.ncbi.nlm.nih.gov/10564741
https://pubmed.ncbi.nlm.nih.gov/10564741
Autor:
Don Richard Finley, Andrew L. Glasebrook, Ellen R. Rowley, Lorri L. Short, Adrian, Martin Michael John, Magee David Edward, David Lynn Phillips, Lewis D. Pennington, Lugar Cw rd, Sung-Yong Stephen Cho, Mark A. Winter, Ken Matsumoto, Harlan W. Cole, Bryant Hu, Timothy Alan Grese, Charles David Jones, Godfrey Ag
Publikováno v:
Journal of medicinal chemistry. 40(2)
The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and treatment of postmenopausal osteoporosis. A series of raloxifene analogs which contain modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82509c0f3ab244dea00fd753c3fcecf
https://pubmed.ncbi.nlm.nih.gov/9003514
https://pubmed.ncbi.nlm.nih.gov/9003514