Zobrazeno 1 - 10
of 684
pro vyhledávání: '"Harlan S"'
Autor:
Stephanie L. Schmit, Ya-Yu Tsai, Joseph D. Bonner, Rebeca Sanz-Pamplona, Amit D. Joshi, Tomotaka Ugai, Sidney S. Lindsey, Marilena Melas, Kevin J. McDonnell, Gregory E. Idos, Christopher P. Walker, Chenxu Qu, W. Martin Kast, Diane M. Da Silva, Jonathan N. Glickman, Andrew T. Chan, Marios Giannakis, Jonathan A. Nowak, Hedy S. Rennert, Harlan S. Robins, Shuji Ogino, Joel K. Greenson, Victor Moreno, Gad Rennert, Stephen B. Gruber
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Objective To evaluate the contribution of germline genetics to regulating the briskness and diversity of T cell responses in CRC, we conducted a genome-wide association study to examine the associations between germline genetic variation and
Externí odkaz:
https://doaj.org/article/bfa9ed09e404405395677a797686e21c
Autor:
Tara K. Sigdel, Paul A. Fields, Juliane Liberto, Izabella Damm, Maggie Kerwin, Jill Hood, Parhom Towfighi, Marina Sirota, Harlan S. Robins, Minnie M. Sarwal
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft biopsy q
Externí odkaz:
https://doaj.org/article/1b36f4a0a7014a5599e2a6c906ed8a76
Autor:
Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, Sudeb Dalai, Ilan Kirsch, Lance Baldo, Laura Manuto, Elisa Franchin, Claudia Del Vecchio, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Andrea Padoan, Mario Plebani, Fabio Simeoni, Jessica Bordini, Nicola I. Lorè, Dejan Lazarević, Daniela M. Cirillo, Paolo Ghia, Stefano Toppo, Jonathan M. Carlson, Harlan S. Robins, Andrea Crisanti, Giovanni Tonon
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
T cells play a prominent role in orchestrating the immune response to viral diseases, but their role in the clinical presentation and subsequent immunity to SARS-CoV-2 infection remains poorly understood. As part of a population-based survey of the m
Externí odkaz:
https://doaj.org/article/ef4ff663260a45f7ba60d15fe32db9e4
Autor:
Rebecca Elyanow, Thomas M. Snyder, Sudeb C. Dalai, Rachel M. Gittelman, Jim Boonyaratanakornkit, Anna Wald, Stacy Selke, Mark H. Wener, Chihiro Morishima, Alexander L. Greninger, Michael Gale Jr., Tien-Ying Hsiang, Lichen Jing, Michael R. Holbrook, Ian M. Kaplan, H. Jabran Zahid, Damon H. May, Jonathan M. Carlson, Lance Baldo, Thomas Manley, Harlan S. Robins, David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell responses, but these responses vary with disease severity and individual characterist
Externí odkaz:
https://doaj.org/article/c720e1a7f2ea4a9bb6e8db6d06e7b8ab
Autor:
Travers Ching, Megan E. Duncan, Tera Newman-Eerkes, Mollie M. E. McWhorter, Jeffrey M. Tracy, Michelle S. Steen, Ryan P. Brown, Srivatsa Venkatasubbarao, Nicholas K. Akers, Marissa Vignali, Martin E. Moorhead, Drew Watson, Ryan O. Emerson, Tobias P. Mann, B. Melina Cimler, Pamela L. Swatkowski, Ilan R. Kirsch, Charles Sang, Harlan S. Robins, Bryan Howie, Anna Sherwood
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background The clonoSEQ® Assay (Adaptive Biotechnologies Corporation, Seattle, USA) identifies and tracks unique disease-associated immunoglobulin (Ig) sequences by next-generation sequencing of IgH, IgK, and IgL rearrangements and IgH-BCL1
Externí odkaz:
https://doaj.org/article/f4765b6429fd4f42acca9201ac81c886
Autor:
Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins, Eric J. Alm
Publikováno v:
BMC Immunology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells
Externí odkaz:
https://doaj.org/article/ce0c5f9640c74c6d895963351a66b37d
Autor:
Sarah A Johnson, Spencer L Seale, Rachel M Gittelman, Julie A Rytlewski, Harlan S Robins, Paul A Fields
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0249484 (2021)
The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random proce
Externí odkaz:
https://doaj.org/article/dee177985d1643a8a813d6a4f72cdbb8
Autor:
Rebeca Sanz-Pamplona, Marilena Melas, Asaf Maoz, Stephanie L Schmit, Hedy Rennert, Flavio Lejbkowicz, Joel K Greenson, Xavier Sanjuan, Maria Lopez-Zambrano, M Henar Alonso, Chenxu Qu, Kevin J McDonnell, Gregory E Idos, Marissa Vignali, Ryan Emerson, Paul Fields, Elisabet Guinó, Cristina Santos, Ramon Salazar, Harlan S Robins, Gad Rennert, Stephen B Gruber, Victor Moreno
Publikováno v:
PLoS Medicine, Vol 17, Iss 9, p e1003292 (2020)
BackgroundIdentifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity. Recently, the intensity and th
Externí odkaz:
https://doaj.org/article/42eadb840c134c0fa73e57c1b9f33f7d
Autor:
Caren Ramien, Erik C. Yusko, Jan Broder Engler, Stefanie Gamradt, Kostas Patas, Nils Schweingruber, Anne Willing, Sina Cathérine Rosenkranz, Anke Diemert, Anja Harrison, Marissa Vignali, Catherine Sanders, Harlan S. Robins, Eva Tolosa, Christoph Heesen, Petra C. Arck, Alexander Scheffold, Kenneth Chan, Ryan O. Emerson, Manuel A. Friese, Stefan M. Gold
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 810-815.e4 (2019)
Summary: Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research
Externí odkaz:
https://doaj.org/article/4927d90c64d54853afb018bd904b32d8
Autor:
Alexandra Snyder, Tavi Nathanson, Samuel A Funt, Arun Ahuja, Jacqueline Buros Novik, Matthew D Hellmann, Eliza Chang, Bulent Arman Aksoy, Hikmat Al-Ahmadie, Erik Yusko, Marissa Vignali, Sharon Benzeno, Mariel Boyd, Meredith Moran, Gopa Iyer, Harlan S Robins, Elaine R Mardis, Taha Merghoub, Jeff Hammerbacher, Jonathan E Rosenberg, Dean F Bajorin
Publikováno v:
PLoS Medicine, Vol 14, Iss 5, p e1002309 (2017)
BACKGROUND:Inhibition of programmed death-ligand 1 (PD-L1) with atezolizumab can induce durable clinical benefit (DCB) in patients with metastatic urothelial cancers, including complete remissions in patients with chemotherapy refractory disease. Alt
Externí odkaz:
https://doaj.org/article/dce1a7888e3c4bdeb85b68605ddcef52