Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Harlan Robins"'
Autor:
Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M. Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, Farrah Kheradmand, Runzhe Chen, Chi-Wan Chow, Heather Lin, Chantale Bernatchez, Ali Jalali, Xin Hu, Chang-Jiun Wu, Agda Karina Eterovic, Edwin Roger Parra, Erik Yusko, Ryan Emerson, Sharon Benzeno, Marissa Vignali, Xifeng Wu, Yuanqing Ye, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Tina Cascone, Alexandra Snyder, Jennifer A. Wargo, Roy Herbst, Stephen Swisher, Humam Kadara, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A. Vaporciyan, Boris Sepesi, Don L. Gibbons, Harlan Robins, Patrick Hwu, John V. Heymach, Padmanee Sharma, James P. Allison, Veera Baladandayuthapani, Jack J. Lee, Mark M. Davis, Ignacio I. Wistuba, P. Andrew Futreal, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tiss
Externí odkaz:
https://doaj.org/article/15a3818a702a41f18e727456b0714f76
Autor:
Tao Peng, Khamsone Phasouk, Emily Bossard, Alexis Klock, Lei Jin, Kerry J. Laing, Christine Johnston, Noel A. Williams, Julie L. Czartoski, Dana Varon, Annalyssa N. Long, Jason H. Bielas, Thomas M. Snyder, Harlan Robins, David M. Koelle, M. Juliana McElrath, Anna Wald, Lawrence Corey, Jia Zhu
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The ectocervix is part of the lower female reproductive tract (FRT), which is susceptible to sexually transmitted infections (STIs). Comprehensive knowledge of the phenotypes and T cell receptor (TCR) repertoire of tissue-resident memory T cells (TRM
Externí odkaz:
https://doaj.org/article/02fce3f48eb1417496f4b8f8b650c7d2
Autor:
Delphine C. Malherbe, Lo Vang, Jason Mendy, Philip T. Barnette, David A. Spencer, Jason Reed, Bettie W. Kareko, D. Noah Sather, Shilpi Pandey, Constantinos K. Wibmer, Harlan Robins, Deborah H. Fuller, Byung Park, Samir K. Lakhashe, James M. Wilson, Michael K. Axthelm, Ruth M. Ruprecht, Penny L. Moore, Jonah B. Sacha, Ann J. Hessell, Jeff Alexander, Nancy L. Haigwood
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Designing immunogens and improving delivery methods eliciting protective immunity is a paramount goal of HIV vaccine development. A comparative vaccine challenge study was performed in rhesus macaques using clade C HIV Envelope (Env) and SIV Gag anti
Externí odkaz:
https://doaj.org/article/c688ddcba1b44dc3ab7482e2ecdbec75
Autor:
Delphine C. Malherbe, Constantinos Kurt Wibmer, Molati Nonyane, Jason Reed, D. Noah Sather, David A. Spencer, Jason T. Schuman, Biwei Guo, Shilpi Pandey, Harlan Robins, Byung Park, Deborah H. Fuller, Jonah B. Sacha, Penny L. Moore, Ann J. Hessell, Nancy L. Haigwood
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy similar to a recent clinical trial that showed improved speed and magnitude of humoral responses
Externí odkaz:
https://doaj.org/article/d97512fa6df54775844c17a2489a0df5
Autor:
Julie Rytlewski, Shibing Deng, Tao Xie, Craig Davis, Harlan Robins, Erik Yusko, Jadwiga Bienkowska
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213684 (2019)
Current methods to quantify T-cell clonal expansion only account for variance due to random sampling from a highly diverse repertoire space. We propose a beta-binomial model to incorporate time-dependent variance into the assessment of differentially
Externí odkaz:
https://doaj.org/article/8be2100aa85f4227b39f285fd1408e16
Autor:
Krystle A Lang Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C Abnet, Neal D Freedman, Ligia A Pinto, David Hamm, Harlan Robins, Allan Hildesheim, Jianxin Shi, Mahboobeh Safaeian
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0178167 (2018)
It is unknown why a minority of women fail to clear human papillomavirus (HPV) and develop precancer/cancer. Differences in T-cell receptor (TCR) repertoires may identify HPV16-infected women at highest-risk for progression to cancer. We conducted a
Externí odkaz:
https://doaj.org/article/6819298b978940c9a94342bce11a9d41
Autor:
Rune A. Høglund, Andreas Lossius, Jorunn N. Johansen, Jane Homan, Jūratė Šaltytė Benth, Harlan Robins, Bjarne Bogen, Robert D. Bremel, Trygve Holmøy
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Memory B cells acting as antigen-presenting cells are believed to be important in multiple sclerosis (MS), but the antigen they present remains unknown. We hypothesized that B cells may activate CD4+ T cells in the central nervous system of MS patien
Externí odkaz:
https://doaj.org/article/23c0957f1c094b83bef38b9a1c64e24b
Autor:
Raul Rabadan, Harlan Robins
Publikováno v:
Evolutionary Bioinformatics, Vol 3, Pp 299-307 (2007)
Influenza is an RNA virus that causes mild to severe respiratory symptoms in humans and other hosts. Every year approximately half a million people around the world die from seasonal Influenza. But this number is substantially larger in the case of p
Externí odkaz:
https://doaj.org/article/be8287943b08461fb9dd5aa53c30c0c7
Autor:
Yaoxing Huang, Michael Krasnitz, Raul Rabadan, Daniela M Witten, Yang Song, Arnold J Levine, David D Ho, Harlan Robins
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3214 (2008)
This manuscript describes a novel strategy to improve HIV DNA vaccine design. Employing a new information theory based bioinformatic algorithm, we identify a set of nucleotide motifs which are common in the coding region of HIV, but are under-represe
Externí odkaz:
https://doaj.org/article/2c794a981a894583a84b3f46eca0de9d
Autor:
James P. Allison, Jedd D. Wolchok, Alexander Y. Rudensky, Padmanee Sharma, Jorge Blando, Achim Jungbluth, Jianda Yuan, Taha Merghoub, Harlan Robins, Christopher Tipton, Ryan Emerson, Marissa Vignali, Melissa Pulitzer, Kathleen S. Panageas, Robert A. Lefkowitz, Charles Fisher, Jamie Rand, Danielle M. Bello, Jian Hu, Robert H. Siegelbaum, Mary Sue Brady, Charlotte E. Ariyan
Clinical responses to immunotherapy have been associated with augmentation of preexisting immune responses, manifested by heightened inflammation in the tumor microenvironment. However, many tumors have a noninflamed microenvironment, and response ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4797e2d3da9e3ae97382f81378381f00
https://doi.org/10.1158/2326-6066.c.6549010.v1
https://doi.org/10.1158/2326-6066.c.6549010.v1
