Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Harlan L. Pietz"'
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across the plasma membrane. However, constitutive MRP1 function hinders dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1364136f1613d8107693c22e47c58c4
https://doi.org/10.1073/pnas.2220012120
https://doi.org/10.1073/pnas.2220012120
Autor:
Kening Wang, David M. Koelle, Sally Hunsberger, Siu Ping Turk, Ronald L Hornung, Aiying Chen, Kerry J. Laing, Chetan Seshadri, Lesia K. Dropulic, Sanjay Phogat, Lee-Jah Chang, Malisa T. Smith, Jeffrey I. Cohen, Makinna C Oestreich, Doreen Garabedian, Nancy Ann Hosken, Keith Lumbard, Harlan L Pietz
Publikováno v:
J Infect Dis
Background Herpes simplex virus 2 (HSV2) causes genital herpes in >400 million persons worldwide. Methods We conducted a randomized, double-blinded, placebo-controlled trial of a replication-defective HSV2 vaccine, HSV529. Twenty adults were enrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abe274934dc0e2f0e6daac07b9d41d2
https://doi.org/10.1093/infdis/jiz225
https://doi.org/10.1093/infdis/jiz225
Autor:
Sally Hunsberger, Mir A. Ali, John Shon, Hanh Nguyen, Keith Lumbard, Jaymie R Sawyer, Joel Bozekowski, Kening Wang, Jack Reifert, Harlan L Pietz, Doreen Garabedian, Winston A. Haynes, Lesia K. Dropulic, Joshua S Vogel, Kennichi C. Dowdell, Patrick S. Daugherty, Sinthujan Jegaskanda, Makinna C Oestreich, Jeffrey I. Cohen
Publikováno v:
J Infect Dis
Previous herpes simplex virus type 2 (HSV-2) vaccines have not prevented genital herpes. Concerns have been raised about the choice of antigen, the type of antibody induced by the vaccine, and whether antibody is present in the genital tract where in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11216d321d2bf602ed6eb4bdf3c2ca0
https://pubmed.ncbi.nlm.nih.gov/33718970
https://pubmed.ncbi.nlm.nih.gov/33718970
Autor:
Joshua T. Schiffer, Daniel Stone, Harshana S. De Silva Feelixge, Keith R. Jerome, Harlan L. Pietz, Pavitra Roychoudhury
Publikováno v:
Journal of Antimicrobial Chemotherapy. 71:2089-2099
Objectives A promising curative approach for HIV is to use designer endonucleases that bind and cleave specific target sequences within latent genomes, resulting in mutations that render the virus replication incompetent. We developed a mathematical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b0ebc6313871ffadf2fbb64051fbab
https://doi.org/10.1093/jac/dkw104
https://doi.org/10.1093/jac/dkw104
Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy
Autor:
Joshua T. Schiffer, Harlan L. Pietz, Harshana S. De Silva Feelixge, Alexander L. Greninger, Daniel Stone, Pavitra Roychoudhury, Keith R. Jerome, Martine Aubert
Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One potential approach to cure persistent viral infections is via the use of targeted endonucleases. Nevertheless, a potential concern for endonuclease-based a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec324b190ab71a97ce0c7a3f481f01c
https://europepmc.org/articles/PMC4724322/
https://europepmc.org/articles/PMC4724322/
Autor:
Harshana S. De Silva Feelixge, Daniel Stone, Joshua T. Schiffer, Alexander L. Greninger, Pavitra Roychoudhury, Harlan L. Pietz, Martine Aubert, Keith R. Jerome
Publikováno v:
Molecular Therapy. 24:S303
Incurable chronic viral infections are a major cause of morbidity and mortality worldwide. One newly emerging approach to cure persistent viral infections is via the use of targeted endonucleases. To date, endonucleases have been used as therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6f5683fbb1e3f21dcfcb75f58f586c6
https://doi.org/10.1016/s1525-0016(16)33573-0
https://doi.org/10.1016/s1525-0016(16)33573-0