Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Harlan Barker"'
Autor:
Ashok Aspatwar, Harlan Barker, Heidi Aisala, Ksenia Zueva, Marianne Kuuslahti, Martti Tolvanen, Craig R. Primmer, Jaakko Lumme, Alessandro Bonardi, Amit Tripathi, Seppo Parkkila, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1577-1586 (2022)
A β-class carbonic anhydrase (CA, EC 4.2.1.1) was cloned from the genome of the Monogenean platyhelminth Gyrodactylus salaris, a parasite of Atlantic salmon. The new enzyme, GsaCAβ has a significant catalytic activity for the physiological reaction
Externí odkaz:
https://doaj.org/article/bdf016d9e23e49eba9c8db7310530d47
Autor:
Ashok Aspatwar, Nanda Kumar Parvathaneni, Harlan Barker, Emilie Anduran, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Seppo Parkkila, Jean-Yves Winum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 109-117 (2020)
With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties agains
Externí odkaz:
https://doaj.org/article/ae51113ffa1b407bb83b8eb665edc381
Autor:
Harlan Barker, Seppo Parkkila
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240647 (2020)
The World Health Organization declared the COVID-19 epidemic a public health emergency of international concern on March 11th, 2020, and the pandemic is rapidly spreading worldwide. COVID-19 is caused by a novel coronavirus SARS-CoV-2, which enters h
Externí odkaz:
https://doaj.org/article/d2ba428dd84441bb8e848da3ece4764c
Autor:
Sini L. Karjalainen, Hannu K. Haapasalo, Ashok Aspatwar, Harlan Barker, Seppo Parkkila, Joonas A. Haapasalo
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Carbonic anhydrase related proteins (CARPs) VIII, X and XI functionally differ from the other carbonic anhydrase (CA) enzymes. Structurally, they lack the zinc binding residues, which are important for enzyme activity of classical
Externí odkaz:
https://doaj.org/article/0a261ce547814652b26907f2f8a72e44
Autor:
Ashok Aspatwar, Holger M. Becker, Nanda Kumar Parvathaneni, Milka Hammaren, Aleksandra Svorjova, Harlan Barker, Claudiu T. Supuran, Ludwig Dubois, Philippe Lambin, Mataleena Parikka, Seppo Parkkila, Jean-Yves Winum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1064-1073 (2018)
Carbonic anhydrase (CA) IX is a hypoxia inducible enzyme that is highly expressed in solid tumours. Therefore, it has been considered as an anticancer target using specific chemical inhibitors. The nitroimidazoles DTP338 and DTP348 have been shown to
Externí odkaz:
https://doaj.org/article/ee9b009ec2c749c69bb0b9778d5a058c
Autor:
Ashok Aspatwar, Milka Hammarén, Sanni Koskinen, Bruno Luukinen, Harlan Barker, Fabrizio Carta, Claudiu T. Supuran, Mataleena Parikka, Seppo Parkkila
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 832-840 (2017)
Inhibition of novel biological pathways in Mycobacterium tuberculosis (Mtb) creates the potential for alternative approaches for treating drug-resistant tuberculosis. In vitro studies have shown that dithiocarbamate-derived β-carbonic anhydrase (β-
Externí odkaz:
https://doaj.org/article/3713130df848413ea6187a1befd2b0f7
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-11 (2014)
Abstract Background The genomes of many insect and parasite species contain beta carbonic anhydrase (β-CA) protein coding sequences. The lack of β-CA proteins in mammals makes them interesting target proteins for inhibition in treatment of some inf
Externí odkaz:
https://doaj.org/article/ab15ce91fd71410aa17bac6110da2876
Publikováno v:
Parasites & Vectors, Vol 7, Iss 1, Pp 1-12 (2014)
Abstract Background Despite the high prevalence of parasitic infections, and their impact on global health and economy, the number of drugs available to treat them is extremely limited. As a result, the potential consequences of large-scale resistanc
Externí odkaz:
https://doaj.org/article/d72c7389016e46dd92d8dd9b6802fc0e
Publikováno v:
Cells, Vol 8, Iss 8, p 812 (2019)
Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial−mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly l
Externí odkaz:
https://doaj.org/article/fe778c0fea734881ad89d78a75f9ade8
Autor:
Ashok Aspatwar, Martti E. E. Tolvanen, Harlan Barker, Leo Syrjänen, Susanna Valanne, Sami Purmonen, Abdul Waheed, William S. Sly, Seppo Parkkila
Publikováno v:
Physiological reviews. 102(3)
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have been the primary model organisms used for the study of various biological phenomena. These models have also been adopted and developed to investigate the phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9633c4f133256e15dc670e51a1a90
https://pubmed.ncbi.nlm.nih.gov/35166161
https://pubmed.ncbi.nlm.nih.gov/35166161