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Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

Autor: Martin, DP, Lytras, S, Lucaci, AG, Maier, W, Grüning, B, Shank, SD, Weaver, S, MacLean, OA, Orton, RJ, Lemey, P, Boni, MF, Tegally, H, Harkins, G, Scheepers, C, Bhiman, JN, Everatt, J, Amoako, DG, San, JE, Giandhari, J, Sigal, A, NGS-SA, Williamson, C, Hsiao, N-Y, Von Gottberg, A, De Klerk, A, Shafer, RW, Robertson, DL, Wilkinson, RJ, Sewell, BT, Lessells, R, Nekrutenko, A, Greaney, AJ, Starr, TN, Bloom, JD, Murrell, B, Wilkinson, E, Gupta, RK, De Oliveira, T, Kosakovsky Pond, SL

Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::48b41e8bc4c0df4e4d9b461e02b4bbb2
http://hdl.handle.net/10044/1/96372

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function.

Autor: Martin DP; Institute of Infectious Diseases and Molecular Medicine, Division Of Computational Biology, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7701, South Africa., Lytras S; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Lucaci AG; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., Maier W; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany, usegalaxy.eu., Grüning B; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany, usegalaxy.eu., Shank SD; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., Weaver S; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA., MacLean OA; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Orton RJ; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Lemey P; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium., Boni MF; Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA, USA., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Harkins G; South African National Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa., Scheepers C; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bhiman JN; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Everatt J; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa., Amoako DG; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa., San JE; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa., Williamson C; Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Division of Medical Virology, University of Cape Town and National Health Laboratory Service, Cape Town South Africa.; Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, South Africa., Hsiao NY; Division of Medical Virology, University of Cape Town and National Health Laboratory Service, Cape Town South Africa., von Gottberg A; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg., De Klerk A; Institute of Infectious Diseases and Molecular Medicine, Division Of Computational Biology, Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town 7701, South Africa., Shafer RW; Division of Infectious Diseases, Department of medicine, Stanford university, Stanford, CA, USA., Robertson DL; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Wilkinson RJ; Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, South Africa.; Francis Crick Institute, Midland Road, London NW1 1AT, UK.; Department of Infectious Diseases, Imperial College London, W12 0NN, UK., Sewell BT; Structural Biology Research Unit, Department of Integrative Biomedical Sciences, Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa., Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Nekrutenko A; Department Of Biochemistry and Molecular Biology, The Pennsylvania State University, usegalaxy.org., Greaney AJ; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Genome Sciences & Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA3., Starr TN; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA., Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Wilkinson E; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science, Stellenbosch University., Gupta RK; Africa Health Research Institute, Durban, South Africa.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science, Stellenbosch University., Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Jan 18. Date of Electronic Publication: 2022 Jan 18.

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ÇALIŞANLARIN ÖRGÜTSEL ADALET ALGILARININ, SOSYAL KAYTARMA DAVRANIŞLARI ÜZERİNDEKİ ETKİSİNDE İZLENİM YÖNETİMİ TAKTİKLERİNİN ARACI ROLÜ.

Autor: MUMLU KARANFİL, Seda¹ smumlu@gelisim.edu.tr, GÜNERİ, Sarp²

Publikováno v: Dumlupinar University Journal of Social Science / Dumlupinar Üniversitesi Soysyal Bilimler Dergisi. 2024, Issue 82, p171-191. 21p.