Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harkamal S. Jhajj"'
Autor:
John S. Schardt, Matthew D. Smith, Harkamal S. Jhajj, Ryen L. O'Meara, Timon S. Lwo, Peter M. Tessier
Publikováno v:
Drug Discov Today
Agonist antibodies that activate cellular signaling have emerged as promising therapeutics for treating myriad pathologies. Unfortunately, the discovery of rare antibodies with the desired agonist functions is a major bottleneck during drug developme
Publikováno v:
Trends in molecular medicine. 29(1)
Agonist antibodies that target immune checkpoints, such as those in the tumor necrosis factor receptor (TNFR) superfamily, are an important class of emerging therapeutics due to their ability to regulate immune cell activity, especially for treating
Autor:
Sanjay Misra, Jie Cui, Harkamal S. Jhajj, Chase W. Kessinger, Jason R. McCarthy, Madeleine S. Grau, Peter Libby, Farouc A. Jaffer
Publikováno v:
Journal of the American Society of Nephrology. 31:931-945
BACKGROUND Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical the
Autor:
Jie Cui, Jason R. McCarthy, Chase W. Kessinger, Madeleine S. Grau, Peter Libby, Sanjay Misra, Harkamal S. Jhajj, Farouc A. Jaffer
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical th
Publikováno v:
Biochemical Engineering Journal. 137:365-374
The widespread use of monoclonal antibodies for therapeutic applications has led to intense interest in optimizing several of their natural properties (affinity, specificity, stability, solubility and effector functions) as well as introducing non-na
Autor:
Jie, Cui, Chase W, Kessinger, Harkamal S, Jhajj, Madeleine S, Grau, Sanjay, Misra, Peter, Libby, Jason R, McCarthy, Farouc A, Jaffer
Publikováno v:
J Am Soc Nephrol
Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical therapies curr
Autor:
Guanming Qi, Chase W Kessinger, Adam Mauskapf, Harkamal S Jhajj, Peter Henke, Farouc A Jaffer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Objective: In this study, we investigated the effects of colchicine on vein wall inflammation and scarring, and thrombus burden/VT resolution, key drivers of the PTS. Methods: Inferior vena cava (IVC) stasis VT were created in C57BL/6 mice (n=60). Co
Autor:
Lang Wang, Guanming Qi, Chase W Kessinger, Harkamal S Jhajj, Wenzhu Li, Peter K Henke, Farouc A Jaffer
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Background: Despite anticoagulant therapy, the post-thrombotic syndrome (PTS) remains a frequent, morbid complication of deep venous thrombosis (DVT). There are no effective clinical approaches beyond anticoagulation to prevent and mitigate PTS, whic
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Background: AVFs are the lifeline of dialysis patients, but can often occlude. The most common cause of AVF failure is inflammation-driven neointimal hyperplasia and thrombosis. Here, we investigated whether statin therapy with well-recognized anti-i
Publikováno v:
Journal of Vascular and Interventional Radiology. 28:S147