Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Harjot K. Saini"'
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 4-27 (2012)
As the specific composition of lipids is essential for the maintenance of membrane integrity, enzyme function, ion channels, and membrane receptors, an alteration in lipid composition or metabolism may be one of the crucial changes occurring during s
Externí odkaz:
https://doaj.org/article/790365bed8d7416f866dc092d1647520
Autor:
Harjot K. Saini-Chohan, Michael G. Holmes, Adam J. Chicco, William A. Taylor, Russell L. Moore, Sylvia A. McCune, Diane L. Hickson-Bick, Grant M. Hatch, Genevieve C. Sparagna
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 8, Pp 1600-1608 (2009)
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown. Enzymes inv
Externí odkaz:
https://doaj.org/article/7cc5d38a1ac741f3a2a59f388296add9
Modification of Ca2+-handling in cardiomyocytes by redox sensitive mechanisms in response to ouabain
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 91:45-55
We examined the role of redox-sensitive signal transduction mechanisms in modifying the changes in [Ca2+]iproduced by ouabain upon incubating adult rat cardiomyocytes with antioxidants or inhibitors of different protein kinases and monitoring alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e7dba4ffdd91d65f34ebb0efd121ae
https://doi.org/10.1139/cjpp-2012-0215
https://doi.org/10.1139/cjpp-2012-0215
Autor:
Robert C. Murphy, William A. Taylor, Grant M. Hatch, Harjot K. Saini-Chohan, Shyamala Dakshinamurti, Genevieve C. Sparagna, Garry X. Shen
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H1415-H1424
Persistent pulmonary hypertension of the newborn (PPHN) results in right ventricular (RV) hypertrophy followed by right heart failure and an associated mitochondrial dysfunction. The phospholipid cardiolipin plays a key role in maintaining mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0284a123fd9600f778edbf3b83d2f0a
https://doi.org/10.1152/ajpheart.00247.2011
https://doi.org/10.1152/ajpheart.00247.2011
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 87:1110-1119
This study was undertaken to test whether Ca2+-handling abnormalities in cardiomyocytes after ischemia–reperfusion (I/R) are prevented by antioxidants such as N-acetyl l-cysteine (NAC), which is known to reduce oxidative stress by increasing the gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8467fff4e438364cbf8345d220b1833e
https://doi.org/10.1139/y09-103
https://doi.org/10.1139/y09-103
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 87:789-797
Repletion of Ca2+ in the Ca2+-depleted heart has been shown to produce cardiac dysfunction, myocardial cell damage, intracellular Ca2+ overload, and defects in sarcolemmal and sarcoplasmic reticulum function (Ca2+ paradox). Although these alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e4aeff724758b0e595449608ba60e0
https://doi.org/10.1139/y09-050
https://doi.org/10.1139/y09-050
Autor:
William A. Taylor, Grant M. Hatch, Michael Holmes, Diane L. M. Hickson-Bick, Russell L. Moore, Sylvia A. McCune, Genevieve C. Sparagna, Harjot K. Saini-Chohan, Adam J. Chicco
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 8, Pp 1600-1608 (2009)
Cardiolipin (CL) is responsible for modulation of activities of various enzymes involved in oxidative phosphorylation. Although energy production decreases in heart failure (HF), regulation of cardiolipin during HF development is unknown. Enzymes inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d763e5caf54cb3997253f1ba168fb0d5
http://www.sciencedirect.com/science/article/pii/S0022227520307616
http://www.sciencedirect.com/science/article/pii/S0022227520307616
Autor:
Grant M. Hatch, Harjot K. Saini-Chohan
Publikováno v:
Current Drug Metabolism. 10:206-219
Congestive heart failure (CHF), a complex clinical syndrome with impaired cardiac pump function, occurs as a consequence of mechanical deformities (pressure and volume overload), myocardial abnormalities (neurohormonal disorders, myocarditis, cardiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d363e02bf4622b5182004cb18725c81
https://doi.org/10.2174/138920009787846314
https://doi.org/10.2174/138920009787846314
Autor:
Delfin Rodriguez-Leyva, Paramjit S. Tappia, Melissa R. Dent, Harjot K. Saini-Chohan, Naranjan S. Dhalla, Vijayan Elimban
Publikováno v:
Cardiovascular Research. 81:429-438
It is commonly held that cardiac remodelling, represented by changes in muscle mass, size, and shape of the heart, explains the progression of congestive heart failure (CHF). However, this concept does not provide any clear information regarding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1f9da55c81d0a57b693f2b9895a1ed
https://doi.org/10.1093/cvr/cvn281
https://doi.org/10.1093/cvr/cvn281
Publikováno v:
Future Cardiology. 4:339-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a951131462390c4cc3b3423decfdfabc
https://doi.org/10.2217/14796678.4.4.339
https://doi.org/10.2217/14796678.4.4.339