Výsledky vyhledávání - "Haritha Durairaj"

SEC23B is required for pancreatic acinar cell function in adult mice

Autor: Mark J. Hoenerhoff, Bradley Nelson, Guojing Zhu, Brooke McKnight, David Ginsburg, Bin Zhang, M. Dolors Sans, John A. Williams, Lesley Everett, Rami Khoriaty, Nancy L. Vogel, Stephen A. Ernst, Haritha Durairaj

Publikováno v: Molecular Biology of the Cell

Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in loss of pancreatic mass, with evidence of cell loss, degeneration of exocrine cells (with smaller-than-normal zymogen granules and ER dilation), ER stress, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e096986ecb8e5b66fadfbf02aa3adaf4
https://doi.org/10.1091/mbc.e17-01-0001

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Paroxetine differentially modulates LPS-induced TNFα and IL-6 production in mouse macrophages

Autor: Michael D. Steury, Haritha Durairaj, Narayanan Parameswaran

Publikováno v: International immunopharmacology. 25(2)

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that is clinically used for the treatment of depression in human patients. Because of recent reports on the role of serotonin in modulating inflammation and the link between inflammation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37086470ce42a28e828878a76fc7ce6f
https://pubmed.ncbi.nlm.nih.gov/25744603

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G-protein coupled receptor kinase-5 mediates inflammation but does not regulate cellular infiltration or bacterial load in polymicrobial sepsis model in mice

Autor: Narayanan Parameswaran, Taehyung Lee, Hongbing Wang, Haritha Durairaj, Nandakumar Packiriswamy, Pongali B. Raghavendra

NFκB-dependent signaling is an important modulator of inflammation in several diseases including sepsis. G-protein-coupled receptor kinase-5 (GRK5) is an evolutionarily conserved regulator of the NFκB pathway. We hypothesized that GRK5 via NFκB re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3cc22f87ed7daa240e446ff0b73c22
https://europepmc.org/articles/PMC3753665/

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Role of myeloid-specific G-protein coupled receptor kinase-2 in sepsis

Autor: Sitaram, Parvataneni, Babu, Gonipeta, Nandakumar, Packiriswamy, Taehyung, Lee, Haritha, Durairaj, Narayanan, Parameswaran

Publikováno v: International journal of clinical and experimental medicine. 4(4)

Previous studies have implicated a critical role for G-protein coupled receptor kinase-2 (GRK2) in sepsis owing to its ability to regulate inflammatory response and chemotaxis of immune cells. We therefore, hypothesized that deletion of GRK2 in myelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0798b8367ec856146b864c9c72b05d03
https://pubmed.ncbi.nlm.nih.gov/22140603

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