Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Harish Srinivas"'
Autor:
Nathalie Fiaschi-Taesch, Jeffrey W. Kleinberger, Ronnie Troxell, Andrew F. Stewart, Harish Srinivas, Mansoor Tanwir, Donald K. Scott, Gabriella P. Casinelli, Fatimah G. Salim, Karen K. Takane, Amy E. Cox, Rachel C. Wills
Publikováno v:
Diabetes. 62:2460-2470
Harnessing control of human β-cell proliferation has proven frustratingly difficult. Most G1/S control molecules, generally presumed to be nuclear proteins in the human β-cell, are in fact constrained to the cytoplasm. Here, we asked whether G1/S m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a63faeb02c7878cba66be48aa66397a
https://doi.org/10.2337/db12-0778
https://doi.org/10.2337/db12-0778
Autor:
Harish Srinivas, Naveena Yanamala, Kira L. Lathrop, Judith Klein-Seetharaman, GuangFeng Zhang, Lin Zhang
Publikováno v:
Molecular Endocrinology. 24:1737-1747
Recent studies have demonstrated the presence of estrogen receptor (ER)β in the mitochondria in various cell types and tissues, but the exact function of this localization remains unclear. In this study, we have examined the function of mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1422c71b622468a7357a2f7a95583d59
https://doi.org/10.1210/me.2010-0125
https://doi.org/10.1210/me.2010-0125
Autor:
Adam M. Farkas, GuangFeng Zhang, Harish Srinivas, Diana Lenzner, Stephanie R. Land, Kira L. Lathrop, Anil V. Parwani, Xuwan Liu
Publikováno v:
Molecular Endocrinology. 23:146-156
Recent studies have shown that estrogens promote the growth of lung cancer cells and may potentially be responsible for increased susceptibility to lung cancer in women. These observations raise the possibility of using antiestrogens in treating and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b1f211d0b321d70ca4e4c81339cbc7
https://doi.org/10.1210/me.2008-0431
https://doi.org/10.1210/me.2008-0431
Autor:
Jonathan M. Kurie, Nancy L. Weigel, Harish Srinivas, Dianna D. Cody, Roger E. Price, Ramesh Narayanan, Denise M. Juroske, Xiao Chun Xu, Shailaja Kalyankrishna
Publikováno v:
Molecular and Cellular Biology. 25:1054-1069
Retinoic acid (RA) is the ligand for nuclear RA receptors (RARs and RXRs) and is crucial for normal epithelial cell growth and differentiation. During malignant transformation, human bronchial epithelial cells acquire a block in retinoid signaling ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a51b31b9363346a9f5f4140f24a0511
https://doi.org/10.1128/mcb.25.3.1054-1069.2005
https://doi.org/10.1128/mcb.25.3.1054-1069.2005
Autor:
Chilukuri N. Rao, Santhi D. Konduri, Harish Srinivas, Niranjan Yanamandra, William C. Olivero, Gregory Kouraklis, Dzung H. Dinh, Meena Gujrati, Anastasia Tasiou, Walter Kisiel, Francis Ali Osman, Jasti S. Rao, Donald C. Foster
Publikováno v:
Oncogene. 21:921-928
Tissue factor pathway inhibitor-2 (TFPI-2), a serine protease inhibitor abundant in the extra cellular matrix, is highly expressed in non-invasive cells but undetectable levels in highly invasive human glioma cells. The mechanisms responsible for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9864ad530fc49308d34918e8cedd93d1
https://doi.org/10.1038/sj.onc.1204983
https://doi.org/10.1038/sj.onc.1204983
Autor:
Young Ho Ahn, Harish Srinivas, Jonathan M. Kurie, W. K. Alfred Yung, Paul J. Chiao, Xiaoyang Sheng, Dianren Xia, Powel H. Brown, Bharat B. Aggarwal, Ignacio I. Wistuba, Gautam Sethi, Heetae Kim, Qianghua Xia
Publikováno v:
The Journal of biological chemistry. 282(6)
Mitogen-activated protein kinase kinase-4 (MKK4/SEK1) cooperates with phosphatidylinositol 3-kinase to maintain the survival of non-small cell lung cancer (NSCLC) cells, but the biochemical basis of this phenomenon has not been elucidated. Here we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd89959cd25e04991ad19434bdaada9f
https://pubmed.ncbi.nlm.nih.gov/17158870
https://pubmed.ncbi.nlm.nih.gov/17158870
Autor:
Luc Girard, Mianen Sun, Jonathan R. Pollack, Harish Srinivas, Diane Liu, Marie Wislez, Amy E. Hanna, Tanvir Khatlani, Kentaro Iwanaga, Ignacio I. Wistuba, John D. Minna, Lijiang Ma, Young Ho Kim, Jonathan M. Kurie
Publikováno v:
Oncogene. 26(18)
c-Jun N-terminal kinase (JNK) has been reported to either potentiate or inhibit oncogenesis, depending upon the cellular context, but its role in lung neoplasia is unclear. Here we sought to define the role of JNK in lung neoplasia by examining evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574970eff2b6cc11f2d4499d410237b8
https://pubmed.ncbi.nlm.nih.gov/17057737
https://pubmed.ncbi.nlm.nih.gov/17057737
Autor:
Long Ma, Nancy L. Weigel, Heetae Kim, Nicole L. Moore, Jonathan M. Kurie, Ivan P. Uray, Powel H. Brown, Dianren Xia, Harish Srinivas
The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARα (retinoic acid receptor α) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47220def71906b26bf3ef020f36731c7
Autor:
Kohjiro Ueki, Harish Srinivas, Garrett L. Walsh, Ho-Young Lee, Jonathan M. Kurie, Ruth LaPushin, Yiling Lu, Annamaria Gal, Thomas Force, Candelaria Gomez-Manzano, Dianren Xia, Robert Superty, Gordon B. Mills
Publikováno v:
University of Brighton
Cancer cells in which the PTEN lipid phosphatase gene is deleted have constitutively activated phosphatidylinositol 3-kinase (PI3K)-dependent signaling and require activation of this pathway for survival. In non-small cell lung cancer (NSCLC) cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56804475da43ad1422087b644c39aa96
https://pubmed.ncbi.nlm.nih.gov/12714585
https://pubmed.ncbi.nlm.nih.gov/12714585