Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Harish R Krishnan"'
Autor:
Alfredo Ghezzi, Harish R Krishnan, Linda Lew, Francisco J Prado, Darryl S Ong, Nigel S Atkinson
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003986 (2013)
Sustained or repeated exposure to sedating drugs, such as alcohol, triggers homeostatic adaptations in the brain that lead to the development of drug tolerance and dependence. These adaptations involve long-term changes in the transcription of drug-r
Externí odkaz:
https://doaj.org/article/0fd2e7fc6f58452883bf1fe37fce68e8
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e265 (2007)
Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adapt
Externí odkaz:
https://doaj.org/article/20683790ed0246c192be776995c1edd6
Publikováno v:
Non-Coding RNA, Vol 9, Iss 6, p 72 (2023)
Although, by definition, long noncoding RNAs (lncRNAs) are not translated, they are sometimes associated with ribosomes. In fact, some estimates suggest the existence of more than 50 K lncRNA molecules that could encode for small peptides. We examine
Externí odkaz:
https://doaj.org/article/8672879db4d34a2d95e840a918ecc5c3
Autor:
Harish R. Krishnan, Huaibo Zhang, Ying Chen, John Peyton Bohnsack, Annie W. Shieh, Handojo Kusumo, Jenny Drnevich, Chunyu Liu, Dennis R. Grayson, Mark Maienschein-Cline, Subhash C. Pandey
Publikováno v:
Molecular psychiatry. 27(11)
Positive effects of alcohol drinking such as anxiolysis and euphoria appear to be a crucial factor in the initiation and maintenance of alcohol use disorder (AUD). However, the mechanisms that lead from chromatin reorganization to transcriptomic chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a83ef020bc54d5e155679aa8615b5a6
https://pubmed.ncbi.nlm.nih.gov/36089615
https://pubmed.ncbi.nlm.nih.gov/36089615
Autor:
Jenny Drnevich, James Auta, Harish R. Krishnan, Eleonora Gatta, Subhash C. Pandey, Erbo Dong, Dennis R. Grayson, Vikram Saudagar, Alessandro Guidotti, Ying Chen
Publikováno v:
Molecular psychiatry
Environmental factors, including substance abuse and stress, cause long-lasting changes in the regulation of gene expression in the brain via epigenetic mechanisms, such as DNA methylation. We examined genome-wide DNA methylation patterns in the pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8521383d405150c393c9844eb7a58a
https://doi.org/10.1038/s41380-019-0449-6
https://doi.org/10.1038/s41380-019-0449-6
Autor:
Mark Maienschein-Cline, Laura B. Ferguson, Amy W. Lasek, R. Dayne Mayfield, Harish R. Krishnan, Kana Hamada
Publikováno v:
Genes Brain Behav
Alcohol use disorder (AUD) has a complex pathogenesis, making it a difficult disorder to treat. Identifying relevant signaling pathways in the brain may be useful for finding new pharmacological targets to treat AUD. The receptor tyrosine kinase anap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5704b41c05f63f04796000b4f7d732b9
https://doi.org/10.1111/gbb.12729
https://doi.org/10.1111/gbb.12729
Autor:
K. Yaragudri Vinod, Harish R. Krishnan, Huaibo Zhang, Russell S Dulman, Subhash C. Pandey, Ritabrata Banerjee, Basalingappa L. Hungund, Bin Dong
Publikováno v:
Neuropharmacology
Alcohol consumption is mediated by several important neuromodulatory systems, including the endocannabinoid and neuropeptide Y (NPY) systems in the limbic brain circuitry. However, molecular mechanisms through which cannabinoid-1 (CB1) receptors regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5e967194a0f089e4a011363a4dd566
https://pubmed.ncbi.nlm.nih.gov/34048869
https://pubmed.ncbi.nlm.nih.gov/34048869
Autor:
Ying Chen, Amy W. Lasek, Hu Chen, Wei-Yang Chen, Dennis R. Grayson, Kana Hamada, Huaibo Zhang, Jenny Drnevich, Eleonora Gatta, Harish R. Krishnan, Subhash C. Pandey, Mark Maienschein-Cline
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new drug targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b6b8234479112e7b3d72f1e21baca3
https://pubmed.ncbi.nlm.nih.gov/34016951
https://pubmed.ncbi.nlm.nih.gov/34016951
Autor:
Subhash C. Pandey, Evan J. Kyzar, Harish R. Krishnan, Amul J. Sakharkar, Dennis R. Grayson, David P. Gavin, Ying Chen, Huaibo Zhang
Publikováno v:
Neuropharmacology
Binge drinking during adolescence increases the risk for neuropsychiatric disorders including alcoholism in adulthood. DNA methylation in post-mitotic neurons is an important epigenetic modification that plays a crucial role in neurodevelopment. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d662bbf073aff21391e528303475ea0
https://europepmc.org/articles/PMC6681823/
https://europepmc.org/articles/PMC6681823/
Publikováno v:
Biological Psychiatry. 80:711-719
Background The antianxiety effects of ethanol appear to be a crucial factor in promoting alcohol intake. Regulation of gene expression by microRNA (miRNA) is an important epigenetic mechanism that affects neuronal pathways and behaviors. We investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df83ac5ebfd2d09c74d6fc9218cc4bdb
https://doi.org/10.1016/j.biopsych.2015.10.028
https://doi.org/10.1016/j.biopsych.2015.10.028