Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Harish P. Janardhan"'
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Akademický článek
Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
Autor: Kevin MingJie Gao, Kristy Chiang, Zhaozhao Jiang, Filiz T. Korkmaz, Harish P. Janardhan, Chinmay M. Trivedi, Lee J. Quinton, Sebastien Gingras, Katherine A. Fitzgerald, Ann Marshak-Rothstein
Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114114- (2024)
Summary: Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STINGV154M mutation (VM). Prior radiat
Externí odkaz: https://doaj.org/article/2a4efdec376a4801b850043d6a406d50
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2
Akademický článek
Pathological MAPK activation–mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib
Autor: Harish P. Janardhan, Karen Dresser, Lloyd Hutchinson, Chinmay M. Trivedi
Publikováno v: JCI Insight, Vol 7, Iss 17 (2022)
Lymphangiectasia, an anomalous dilation of lymphatic vessels first described in the 17th century, is frequently associated with chylous effusion, respiratory failure, and high mortality in young patients, yet the underlying molecular pathogenesis and
Externí odkaz: https://doaj.org/article/4b36983a53aa467d89a49bbaf4f56a3a
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6
Establishment and maintenance of blood–lymph separation
Autor: Chinmay M. Trivedi, Harish P. Janardhan
Publikováno v: Cell Mol Life Sci
Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dce510b25fc3f13d1ad87ea637034b6
https://doi.org/10.1007/s00018-019-03042-3
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7
Vascular and Lymphatic Malformations – Perspectives from Human and Vertebrate Studies
Autor: Sherin Saheera, Chinmay M. Trivedi, Harish P. Janardhan, Roy Jung
Publikováno v: Circ Res
Vascular malformations, affecting ≈1% to 1.5% of the population, comprise a spectrum of developmental patterning defects of capillaries, arteries, veins, and/or lymphatics. The majority of vascular malformations occur sporadically; however, inherit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1535bafed7f9871b99e638860f97ac47
https://europepmc.org/articles/PMC8238353/
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9
KRAS or BRAF mutations cause hepatic vascular cavernomas treatable with MAP2K–MAPK1 inhibition
Autor: Lloyd Hutchinson, Chinmay M. Trivedi, Karen Dresser, Harish P. Janardhan, Xiuling Meng
Publikováno v: The Journal of Experimental Medicine
This study demonstrates endothelial KRAS or BRAF gain-of-function mutations as a causal mechanism for hepatic vascular cavernomas, the most common benign tumor of the liver. RAS-MAPK1 signaling inhibition rescues hepatic vascular cavernoma formation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e6610d38991aee0b19f950a5fbd3cc
https://doi.org/10.1084/jem.20192205
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10
Hdac3 regulates lymphovenous and lymphatic valve formation
Autor: John F. Keaney, Masahiro Shin, Nathan D. Lawson, Harish P. Janardhan, Chinmay M. Trivedi, Zachary J. Milstone
Publikováno v: The Journal of Clinical Investigation
Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive. Here, we showed that during mouse development, the histone-modifying
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4543ace2212dd0696affeb136449ac
https://doi.org/10.1172/jci92852
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