Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Harish Karne"'
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2019)
Background: This study has, for the first time, investigated the dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) resting state whole-brain functional connectivity in medication-free young adults with major depression (MDD), at baseline an
Externí odkaz:
https://doaj.org/article/e208c7ecabbf49d69d0c814a57778da2
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Background: Dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) are major brainstem monamine nuclei consisting of serotonin and dopamine neurons respectively. Animal studies show that firing patterns in both nuclei are altered when animals ex
Externí odkaz:
https://doaj.org/article/fa083e1eeaef4c918f0cf3bdbb33bbf0
Autor:
Jeffrey M. Spielberg, Amy Kuceyeski, Sidra L Speaker, Harish Karne, Murat Altinay, Parashar Koirala, Bo Hu, Amit Anand, Elvisha Dhamala, Jungwon Cha
Publikováno v:
J Affect Disord
BACKGROUND: Many subjects with major depression (MDD) exhibit subthreshold mania symptoms (MDD+). This study investigated, for the first time, using emotional inhibition tasks, whether the neural organization of MDD+ subjects is more similar to bipol
Publikováno v:
Brain Imaging Behav
Resting-state connectivity studies, which examine unconstrained low frequency BOLD fluctuations, have reported inconsistent abnormalities in bipolar disorder (BP). In this study, we investigated intrinsic brain connectivity under the constraints of a
Autor:
Amy L. DiVita, Bo Hu, Kelly A. Bryant, Jess G. Fiedorowicz, Manshi Li, Murat Altinay, Parashar Koirala, Harish Karne, Amit Anand
Publikováno v:
Journal of Psychiatric Research. 110:1-8
This study, for the first time, compared illness and antidepressant response characteristics of young subjects with major depression (MDD) at low (LRMDD) or high-risk (HRMDD) for developing bipolar disorder with characteristics of young bipolar (BPD)
Publikováno v:
Bipolar Disord
Objectives Lithium is one of the most effective and specific treatments for bipolar disorder (BP), but the neural mechanisms by which lithium impacts symptoms remain unclear. Past research has been limited by a reliance on cross-sectional designs, wh
Autor:
Bo Hu, Jeffrey M. Spielberg, Sidra L Speaker, Harish Karne, Murat Altinay, Parashar Koirala, Jungwon Cha, Amit Anand
BackgroundA significant number of subjects with major depression (MDD) exhibit subthreshold mania symptoms (MDD+). This study investigated, for the first time, using emotional inhibition tasks, whether the neurobiology of MDD+ subjects is more akin t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44463a30259c6fd056395ec8693644b0
https://doi.org/10.1101/2020.04.25.060111
https://doi.org/10.1101/2020.04.25.060111
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Lithium is a highly effective medication for bipolar disorder, but its mechanism of action remains unknown. In this study, brain MRI scans and blood samples for gene expression (total of 110 scans and 109 blood samples) were collected from 21 bipolar
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2019)
Frontiers in Psychiatry
Frontiers in Psychiatry
Background: This study has, for the first time, investigated the dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) resting state whole-brain functional connectivity in medication-free young adults with major depression (MDD), at baseline an
Autor:
Erik B. Beall, Harish Karne, Leslie A. Hulvershorn, Murat Altinay, Jeffrey M. Spielberg, Amit Anand
Publikováno v:
Neuropsychopharmacology. 41:3016-3024
Research on resting functional brain networks in bipolar disorder (BP) has been unable to differentiate between disturbances related to mania or depression, which is necessary to understand the mechanisms leading to each state. Past research has also