Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Harish C. Sikka"'
Publikováno v:
Chemical Research in Toxicology. 17:672-678
To assess the role of human and rat cytochrome P450s in the metabolism of aza-polynuclear aromatic hydrocarbons (aza-PAHs) and to examine the influence of heterocyclic nitrogen on the metabolism of these chemicals, we have investigated the biotransfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d079b3a341395bf1fcc0ace0b90714e8
https://doi.org/10.1021/tx049979i
https://doi.org/10.1021/tx049979i
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 545:11-21
Benzo[b]phenanthro[2,3-d]thiophene (BPT), and a number of its metabolites, including BPT-3,4-diol, BPT sulfoxide, BPT sulfone, and 3-hydroxyBPT were assessed for their mutagenic activity in Salmonella typhimurium strain TA100, and S. typhimurium base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af38769e5cddb6b3a7f2a58059cf7a00
https://doi.org/10.1016/s0027-5107(03)00138-6
https://doi.org/10.1016/s0027-5107(03)00138-6
Publikováno v:
Polycyclic Aromatic Compounds. 24:527-536
Phenanthro[3,4-b]thiophene (P[3,4-b]T) and phenanthro[4,3-b]thiophene (P[4,3-b]T) are thiasters of weakly mutagenic benzo[c]phenanthrene (B[c]P). These polycyclic sulfur heterocycles (thia-PAHs) represent a group of chemicals which have been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db4923805c2a8b694be5d9b4f713526
https://doi.org/10.1080/10406630490471582
https://doi.org/10.1080/10406630490471582
Autor:
Subodh Kumar, Sumaira Munir, Atul Kumar, Zhi-Xin Yuan, and A. V. Muruganandam, Harish C. Sikka
Publikováno v:
Chemical Research in Toxicology. 16:1581-1588
Benzo[b]phenanthro[2,3-d]thiophene (BPT), a thia analogue of dibenz[a,h]anthracene (DBA), is a carcinogenic environmental pollutant. We have examined the metabolism of BPT by rodent liver microsomes to investigate the mechanism by which BPT produces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d7074ec82b78a5f78e75e7386304a7
https://doi.org/10.1021/tx0341310
https://doi.org/10.1021/tx0341310
Publikováno v:
Aquatic Toxicology. 64:407-418
We have investigated the regio- and stereoselective metabolism of phenanthrene by the liver microsomes of brown bullhead (Ameriurus nebulosus), a bottom dwelling fish species. The liver microsomes from untreated and 3-methylcholanthrene (3-MC)-treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c0f84e24412c9ddc124e07c9ba7c84
https://doi.org/10.1016/s0166-445x(03)00075-4
https://doi.org/10.1016/s0166-445x(03)00075-4
Publikováno v:
Polycyclic Aromatic Compounds. 22:621-630
The ability of Sphingomonas paucimobilis strain EPA 505 (a soil bacterium capable of utilizing fluoranthene as the sole source of carbon and energy for growth) to metabolize 3-methyl-methylfluoranthene, 7-methlybenz[ a ]anthracene, 5-methylchrysene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738217723ac31970a71a044d26aab34a
https://doi.org/10.1080/10406630290103799
https://doi.org/10.1080/10406630290103799
Autor:
Tanja Hansen, Jürgen Borlak, Stefan Schmidbauer, Harish C. Sikka, Heinz Frank, Albrecht Seidel, Jürgen Jacob, Subodh Kumar, Zhi-Xin Yuan
Publikováno v:
Polycyclic Aromatic Compounds. 21:73-86
3-Nitrobenzanthrone (NBA) is a suspected human carcinogen and has been identified in diesel exhaust and in airborne particulates. Human exposure to NBA is thought to occur primarily via the respiratory tract and bronchial as well as alveolar epitheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e239633526b0a6c360040065d8288126
https://doi.org/10.1080/10406630008028525
https://doi.org/10.1080/10406630008028525
Autor:
Subodh Kumar, Sangeet A. Honey, Harish C. Sikka, Adam T. Drahushuk, James R. Olson, Patrick O’Keefe
Publikováno v:
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 126:285-292
The metabolism of benzo(a)pyrene [BP], a model carcinogenic PAH, by hepatic microsomes of two duck species, mallard (Anas platyrhynchos) and common merganser (Mergus merganser americanus) collected from chemically-contaminated and relatively non-cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dede24897d4bc97fa6403a69bb61aec2
https://doi.org/10.1016/s0742-8413(00)00121-3
https://doi.org/10.1016/s0742-8413(00)00121-3
Publikováno v:
Chemico-Biological Interactions. 118:87-97
Bay-region diol epoxides are considered the putative ultimate carcinogens of polynuclear aromatic hydrocarbons. However, the results of studies on tumorigenesis and DNA binding of benzo[ a ]pyrene (BP) and its bay-region diol epoxide, (+)- trans -7,8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b74d9461f9580a09d704df4913fe66b
https://doi.org/10.1016/s0009-2797(98)00116-1
https://doi.org/10.1016/s0009-2797(98)00116-1
Publikováno v:
Aquatic Toxicology. 45:1-8
In order to assess the differences in the ability of fish and rat liver to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), we have investigated the metabolism of dibenzo[a,l]pyrene (DB[a,l]P), a highly potent carcinogenic PAH, by liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdee6ca2a9e6594767583e5ce8a88960
https://doi.org/10.1016/s0166-445x(98)00096-4
https://doi.org/10.1016/s0166-445x(98)00096-4