Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Haris Jahic"'
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Erik Wilker, Lina Gu, Charles B. Davis, Doug Whittington, Deepali Gotur, Haris Jahic, Matthew J. Goldstein, Alan Huang, John P. Maxwell
Publikováno v:
Molecular Cancer Therapeutics. 20:P214-P214
PRMT5 is a type II arginine methyltransferase that regulates essential cellular functions via symmetric dimethylation of target proteins involved in spliceosome regulation, cell cycle progression, apoptosis, the DNA-damage response, and other functio
Publikováno v:
ACS Infectious Diseases. 3:833-844
ETX2514 is a non-β-lactam serine β-lactamase inhibitor in clinical development that has greater potency and broader spectrum of β-lactamase inhibition than the related diazabicyclooctanone avibactam. Despite opening of its cyclic urea ring upon ac
Autor:
Cuyue Tang, Michael John Munchhof, Kat Cosmopoulos, Kip A. West, Mikel P. Moyer, Sherri Smith, Lorna Helen Mitchell, Margaret Porter Scott, Haris Jahic, Alexandra R. Grassian, Megan Alene Cloonan Foley, Thomas V. Riera, Darren Martin Harvey, Scott Ribich, P. Ann Boriack-Sjodin, Kevin Wayne Kuntz, Nigel J. Waters, Dorothy Brach, Christine Klaus, J. Joshua Smith, Robert A. Copeland, Trupti Lingaraj, Elizabeth A. Admirand, Jennifer Totman, Michael Thomenius, Christina R. Majer, Tim J. Wigle, Richard Chesworth, Alejandra Raimondi, Jodi Gureasko, Nathalie Rioux, James Edward John Mills, Suzanne L. Jacques, William P. Janzen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Autor:
Haris Jahic, Kerry E. Murphy-Benenato, P. Ann Boriack-Sjodin, Dan Carcanague, Jenna Harang, Tina Howard, Claire Brassington, Madhusudhan Reddy Gowravaram, Charles J. Eyermann, Lakshmaiah Gingipalli, Herbert Oguto, Sahil Patel, Robert A. Giacobbe, Ludovic Otterbein, Amy Kutschke, James T. Loch, Georgine Ioannidis, Valerie A. Laganas, Michael R. Hale, Adam B. Shapiro, Kevin J. Embrey, Matthew D. Miller
Publikováno v:
Tetrahedron Letters. 56:3108-3112
Bacterial NAD+-dependent DNA ligase (LigA) is an essential enzyme involved in the repair, replication, and recombination of DNA in all bacteria, making it an attractive target in antibacterial drug discovery. A novel series of LigA inhibitors was dis
Autor:
Jean Denis Docquier, Filomena De Luca, David E. Ehmann, Sushmita D. Lahiri, Manuela Benvenuti, Stefano Mangani, Thomas F. Durand-Reville, Haris Jahic, Richard A. Alm, Gian Maria Rossolini
Publikováno v:
ACS Chemical Biology. 10:591-600
The Class D (or OXA-type) β-lactamases have expanded to be the most diverse group of serine β-lactamases with a highly heterogeneous β-lactam hydrolysis profile and are typically resistant to marketed β-lactamase inhibitors. Class D enzymes are i
Autor:
Joseph Kim, Brendan McKeown, Haris Jahic, Kunal Patel, Adriana Catalli, Marianna Kulka, Catherine Neto, Robert Hurta
Publikováno v:
Functional Foods in Health and Disease, Vol 4, Iss 4, Pp 130-146 (2014)
Background: Prostate cancer is one of the most common cancers in the world. There are genetic and environmental factors that can potentially impact the development and progression of many types of cancer, including prostate cancer. As a consequence o
Publikováno v:
Biochemical Pharmacology. 84:654-660
The NAD-dependent DNA ligase is an excellent target for the discovery of antibacterial agents with a novel mode of action. In this work the DNA ligase from Streptococcus pneumoniae was investigated for its steady-state kinetic parameters and inhibiti
Autor:
Haris Jahic, Stewart L. Fisher, Gunther Kern, David E. Ehmann, Rong-Fang Gu, Jun Hu, Philip L. Ross, Grant K. Walkup
Publikováno v:
Proceedings of the National Academy of Sciences. 109:11663-11668
Avibactam is a β-lactamase inhibitor that is in clinical development, combined with β-lactam partners, for the treatment of bacterial infections comprising Gram-negative organisms. Avibactam is a structural class of inhibitor that does not contain
Autor:
Haris Jahic, Laurel Hajec, Adam B. Shapiro, Jason Thresher, Swati Prasad, David E. Ehmann, Ning Gao
Publikováno v:
SLAS Discovery. 15:1088-1098
The degree of supercoiling of DNA is vital for cellular processes, such as replication and transcription. DNA topology is controlled by the action of DNA topoisomerase enzymes. Topoisomerases, because of their importance in cellular replication, are