Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harini Ramalingam"'
Autor:
Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund C. Lee, Vishal Patel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
ADPKD, a common aetiology of kidney failure, is caused by heterozygous PKD1 or PKD2 mutations. Here the authors show that preventing 3′-UTR cis-inhibition of mRNAs produced by the non-inactivated PKD1/2 alleles ameliorates preclinical ADPKD.
Externí odkaz:
https://doaj.org/article/5c3d27a136564233923d3e2f24e558f2
Autor:
Harini Ramalingam, Vishal Patel
Publikováno v:
Journal of the American Society of Nephrology : JASN.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df5ffa07f868d762d68ea1fcf1e0483
https://pubmed.ncbi.nlm.nih.gov/35918148
https://pubmed.ncbi.nlm.nih.gov/35918148
Autor:
Harini, Ramalingam, Sonu, Kashyap, Patricia, Cobo-Stark, Andrea, Flaten, Chun-Mien, Chang, Sachin, Hajarnis, Kyaw Zaw, Hein, Jorgo, Lika, Gina M, Warner, Jair M, Espindola-Netto, Ashwani, Kumar, Mohammed, Kanchwala, Chao, Xing, Eduardo N, Chini, Vishal, Patel
Publikováno v:
Cell metabolism. 33(6)
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8391fc0eb3b1c35ac7126ab4ee0305f4
https://pubmed.ncbi.nlm.nih.gov/33948026
https://pubmed.ncbi.nlm.nih.gov/33948026
Autor:
Laurence Biggers, Thomas L. Carroll, Peter Igarashi, Ronak Lakhia, Harini Ramalingam, Vishal Patel, Silvia Ferrè, Darren P. Wallace, Karam Aboudehen, Matanel Yheskel, Abheepsa Mishra, Andrea Flaten, Christopher P. Chaney
Publikováno v:
JCI Insight
Renal cysts are the defining feature of autosomal dominant polycystic kidney disease (ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of this disorder. Recent studies suggest that immune cells in the cyst micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358221b171d7f39b3fb1f5ea0b3ba291
https://doi.org/10.1172/jci.insight.133785
https://doi.org/10.1172/jci.insight.133785
Autor:
M. Todd Valerius, Amrita Das, Thomas L. Carroll, Michael Rauchman, Alicia R. Fessler, Leif Oxburgh, Andrew P. McMahon, Aaron C. Brown, Lynn Robbins, Jeannine Basta, Harini Ramalingam
Publikováno v:
Developmental Biology. 440:13-21
Formation of a functional kidney depends on the balance between renewal and differentiation of nephron progenitors. Failure to sustain this balance can lead to kidney failure or stem cell tumors. For nearly 60 years, we have known that signals from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9373ae4589058ccafafb1cd48930c09
https://doi.org/10.1016/j.ydbio.2018.04.020
https://doi.org/10.1016/j.ydbio.2018.04.020
Autor:
Joshua T. Mendell, Yang Xie, Dinesh Rakheja, Hema Manjunath, Yangjian Liu, Asha Acharya, Thomas L. Carroll, Harini Ramalingam, James A. Richardson, Robert E. Hammer, Ryan Hunter, He Zhang, Beibei Chen, Benjamin T. Jones
Publikováno v:
Genes & Development. 32:903-908
Loss of function of the DIS3L2 exoribonuclease is associated with Wilms tumor and the Perlman congenital overgrowth syndrome. LIN28, a Wilms tumor oncoprotein, triggers the DIS3L2-mediated degradation of the precursor of let-7, a microRNA that inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f356e1c170b56009087602673029dc
https://doi.org/10.1101/gad.315804.118
https://doi.org/10.1101/gad.315804.118
Autor:
Sonu Kashyap, Chao Xing, Patricia Cobo-Stark, Jorgo Lika, Sachin Hajarnis, Harini Ramalingam, Kyaw Zaw Hein, Gina M. Warner, Mohammed Kanchwala, Eduardo N. Chini, Ashwani Kumar, Vishal Patel, Jair Machado Espindola-Netto, Chun Mien Chang, Andrea Flaten
Publikováno v:
Cell Metabolism. 33:1234-1247.e7
Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N6-methyladenosine (m6A) RNA modification, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df2b6d314a29f4ad9210534210acc6e2
https://doi.org/10.1016/j.cmet.2021.03.024
https://doi.org/10.1016/j.cmet.2021.03.024
Publikováno v:
Cell Signal
Purpose of review microRNAs (miRNAs) are a class of small, evolutionarily conserved, non-coding RNAs (ncRNAs) that function as inhibitors of post-transcriptional mRNA expression. They are implicated in the pathogenesis of numerous diseases, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb53dc703ea5d9ac1571d36779e1ffa
https://doi.org/10.1016/j.cellsig.2020.109548
https://doi.org/10.1016/j.cellsig.2020.109548
Autor:
Harini Ramalingam, Shuta Ishibe, David R. Critchley, Reinhard Fässler, Ambra Pozzi, Charles R. Sanders, Sijo Mathew, Glenda Mernaugh, Thomas L. Carroll, Riya J. Palamuttam, Roy Zent, Ming-Zhi Zhang, Zhenwei Lu
Publikováno v:
Development.
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins, are heterodimeric transmembrane receptors consisting of α and β subunits and critical integrins in the kidney collecting system expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8c1012d5ec65796a51c0a1f4998be1
https://doi.org/10.1242/dev.149914
https://doi.org/10.1242/dev.149914
Autor:
Isaline Rowe, Manila Boca, Maddalena Castelli, Alessandra Boletta, Harini Ramalingam, Gianfranco Distefano, Thomas L. Carroll, Marco Chiaravalli
Publikováno v:
Nature communications
Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified by the kidney, where defective establishment or maintenance of tubular diameter results in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7688d9c83d11aac9d2230c806c34d67e
https://pubmed.ncbi.nlm.nih.gov/24153433
https://pubmed.ncbi.nlm.nih.gov/24153433