Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Harini Nivarthi"'
Autor:
Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Thanh Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Recurrent gain-of-function mutations in the transcription factors STAT5A and much more in STAT5B were found in hematopoietic malignancies with the highest proportion in mature T- and natural killer-cell neoplasms (peripheral T-cell lymphoma, PTCL). N
Externí odkaz:
https://doaj.org/article/7219ee938f624a009dceae930c2be567
Autor:
Shila Gilbert, Harini Nivarthi, Christopher N. Mayhew, Yuan-Hung Lo, Taeko K. Noah, Jefferson Vallance, Thomas Rülicke, Mathias Müller, Anil G. Jegga, Wenjuan Tang, Dongsheng Zhang, Michael Helmrath, Noah Shroyer, Richard Moriggl, Xiaonan Han
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 209-225 (2015)
Intestinal epithelial stem cells (IESCs) control the intestinal homeostatic response to inflammation and regeneration. The underlying mechanisms are unclear. Cytokine-STAT5 signaling regulates intestinal epithelial homeostasis and responses to injury
Externí odkaz:
https://doaj.org/article/8498f806948244d9876a0a3ba7c9fec6
Publikováno v:
American Journal of Hematology. 97
Autor:
Oleh Zagrijtschuk, Harini Nivarthi, Thomas Balligand, Roman Lesyk, Ruochen Jia, Vasyl Atamanyuk, Stefan N. Constantinescu, Erica Xu, Audrey Nedelec, Leon Kutzner, Jakob Weinzierl, Stefan Kubicek, Robert Kralovics
Publikováno v:
Blood, Vol. 137, no. 14, p. 1920-1931 (2021)
Somatic mutations of calreticulin (CALR) have been identified as a main disease driver of myeloproliferative neoplasms, suggesting that development of drugs targeting mutant CALR is of great significance. Site-directed mutagenesis in the N-glycan bin
Autor:
Harini Nivarthi, Oleh Zagrijtschuk, Eva Hug, Christoph J. Binder, Cecilia Varga, Andrea Majoros, D. Tsiantoulas, Anoop Kavirayani, Sarada Achyutuni, Ruochen Jia, Christina Schueller, Michael Schuster, Christoph Bock, Martin Senekowitsch, Robert Kralovics
Publikováno v:
American journal of hematologyREFERENCES. 96(6)
Myeloproliferative neoplasms (MPNs) are characterized by a pathologic expansion of myeloid lineages. Mutations in JAK2, CALR and MPL genes are known to be three prominent MPN disease drivers. Mutant CALR (mutCALR) is an oncoprotein that interacts wit
Autor:
Markus Hengstschläger, Mohamed Elabd, Eva Grundschober, Tahereh Javaheri, Barbara Maurer, Florian Grebien, Ha Thi Thanh Pham, Michaela Prchal-Murphy, Veronika Sexl, Reinhard Grausenburger, Thomas Rülicke, Auke Boersma, Zahra Kazemi, Richard Moriggl, Matthias Farlik, Jan Pencik, Christoph Bock, Lukas Kenner, Stefan Kubicek, Thomas Kolbe, Peter Valent, Mathias Müller, Harini Nivarthi, Florian Halbritter
Publikováno v:
The Journal of Clinical Investigation
Journal of Clinical Investigation
Journal of Clinical Investigation
STAT5B is often mutated in hematopoietic malignancies. The most frequent STAT5B mutation, Asp642His (N642H), has been found in over 90 leukemia and lymphoma patients. Here, we used the Vav1 promoter to generate transgenic mouse models that expressed
Autor:
B Prieler, Daniela Unterleuthner, Wolfgang Sommergruber, Nina Kramer, Helmut Dolznig, Ilija Crncec, Martin Scherzer, J Schmöllerl, Markus Hengstschläger, Julia Schüler, Harini Nivarthi, Thomas Schwarz, D Lenhardt, Angelika Riedl, Christine Unger, Xiaonan Han, Albin Rudisch, Matthias Artaker, Richard Moriggl, Robert Eferl
Publikováno v:
Oncogene. 36:5460-5472
The canonical WNT signaling pathway is crucial for intestinal stem cell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC) development. Here, we show for the first time that WNT2 is one of the most significantly induced g
Autor:
Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Than Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta
Publikováno v:
Haematologica
Autor:
Andrea Majoros, Christina M. Schueller, Robert Kralovics, Ruochen Jia, Harini Nivarthi, Sarada Achyutuni, Roland Jäger
Publikováno v:
Blood. 136:20-20
Myeloproliferative neoplasms (MPNs) are a group of hematopoietic stem cell disorders driven by mutations that constitutively activate physiologic signal transduction pathways essential for hematopoiesis. The majority of patients with classical MPNs h
Autor:
Andrea Majoros, Raimund Holly, Beatrice Grabner, Eva Hug, Roland Jäger, Ruochen Jia, Chung-Wei Lee, Shin-Jye Lee, Robert Kralovics, Felix Rosebrock, Sarada Achyutuni, Harini Nivarthi
Publikováno v:
Blood. 136:53-53
The curative potential of Type I interferons for patients suffering from Myeloproliferative Neoplasms (MPNs) has been reported and these are the only class of drugs that can lead to reduction of the mutant allelic burden in patients. However, modelli