Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harini Nagaraj"'
Autor:
Ritabrita Goswami, Ahmed Nabawy, Mingdi Jiang, Yagiz Anil Cicek, Muhammad Aamir Hassan, Harini Nagaraj, Xianzhi Zhang, Vincent M Rotello
Publikováno v:
Nanomaterials, Vol 14, Iss 19, p 1556 (2024)
Macrophages are multifunctional immune cells essential for both innate and adaptive immune responses. Tumor-associated macrophages (TAMs) often adopt a tumor-promoting M2-like phenotype, aiding tumor progression and immune evasion. Reprogramming TAMs
Externí odkaz:
https://doaj.org/article/17c59ce7361b46de80165e209ee178a3
Autor:
Ritabrita Goswami, Victor Lehot, Yağız Anıl Çiçek, Harini Nagaraj, Taewon Jeon, Terry Nguyen, Stefano Fedeli, Vincent M. Rotello
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 218 (2023)
Current intracellular protein delivery strategies face the challenge of endosomal entrapment and consequent degradation of protein cargo. Methods to efficiently deliver proteins directly to the cytosol have the potential to overcome this hurdle. Here
Externí odkaz:
https://doaj.org/article/7713916ca44f400e8971b1793a31cd04
Autor:
Taewon Jeon, David C. Luther, Ritabrita Goswami, Charlotte Bell, Harini Nagaraj, Yagiz Anil Cicek, Rui Huang, Javier A. Mas-Rosario, James L. Elia, Jungkyun Im, Yi-Wei Lee, Yuanchang Liu, Federica Scaletti, Michelle E. Farkas, Jesse Mager, Vincent M. Rotello
Publikováno v:
ACS Nano. 17:4315-4326
Autor:
David C. Luther, Yi-Wei Lee, Harini Nagaraj, Vincent Clark, Taewon Jeon, Ritabrita Goswami, Sanjana Gopalakrishnan, Stefano Fedeli, William Jerome, James L. Elia, Vincent M. Rotello
Publikováno v:
ACS Nano. 16:7323-7330
Current strategies for the delivery of proteins into cells face general challenges of endosomal entrapment and concomitant degradation of protein cargo. Efficient delivery directly to the cytosol overcomes this obstacle: we report here the use of bio
Direct Cytosolic Delivery of Proteins Using Lyophilized and Reconstituted Polymer-Protein Assemblies
Autor:
David C. Luther, Harini Nagaraj, Ritabrita Goswami, Yağız Anıl Çiçek, Taewon Jeon, Sanjana Gopalakrishnan, Vincent M. Rotello
Publikováno v:
Pharmaceutical Research. 39:1197-1204
Cytosolic delivery of proteins accesses intracellular targets for chemotherapy and immunomodulation. Current delivery systems utilize inefficient endosomal pathways of uptake and escape that lead to degradation of delivered cargo. Cationic poly(oxano
Publikováno v:
Trends Pharmacol Sci
Protein-based therapeutics have unique therapeutic potential due to their specificity, potency, and low toxicity. The vast majority of intracellular applications of proteins require access to the cytosol. Direct entry to the cytosol is challenging du
Autor:
Harini Nagaraj, Yi-Wei Lee, David C. Luther, Dongkap Kim, Taewon Jeon, Vincent M. Rotello, Ritabrita Goswami
Publikováno v:
Bioconjug Chem
Intracellular protein delivery is a transformative tool for biologics research and medicine. Delivery into the cytosol allows proteins to diffuse throughout the cell and access subcellular organelles. Inefficient delivery caused by endosomal entrapme
Autor:
Taewon Jeon, Xianzhi Zhang, Vincent M. Rotello, Rui Huang, David C. Luther, Yi-Wei Lee, Harini Nagaraj
Publikováno v:
Adv Drug Deliv Rev
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical properties. Equally importantly, the structural and functional diversity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb167fde79a4c63818f220f1aad4bf86
https://europepmc.org/articles/PMC8559718/
https://europepmc.org/articles/PMC8559718/
Publikováno v:
Expert Opinion on Drug Delivery. 15:905-913
Therapeutic gene editing is becoming a viable biomedical tool with the emergence of the CRISPR/Cas9 system. CRISPR-based technologies have promise as a therapeutic platform for many human genetic diseases previously considered untreatable, providing
Autor:
Amy S. Burnside, Gulen Yesilbag Tonga, Laura J Castellanos-García, Tristan Tay, Rubul Mout, Riddha Das, Moumita Ray, Erin L. Phillips, Joseph Hardie, Yuanchang Liu, Harini Nagaraj, Richard W. Vachet, Yi-Wei Lee, David C. Luther, Vincent M. Rotello
Publikováno v:
Adv Ther (Weinh)
Macrophages are key effectors of host defense and metabolism, making them promising targets for transient genetic therapy. Gene editing through delivery of the Cas9-ribonucleoprotein (RNP) provides multiple advantages over gene delivery-based strateg