Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Harini, Natarajan"'
Autor:
Andrew P. Hederman, Harini Natarajan, Leo Heyndrickx, Kevin K. Ariën, Joshua A. Wiener, Peter F. Wright, Evan M. Bloch, Aaron A. R. Tobian, Andrew D. Redd, Joel N. Blankson, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E. Ackerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract SARS-CoV-2 variants have continuously emerged in the face of effective vaccines. Reduced neutralization against variants raises questions as to whether other antibody functions are similarly compromised, or if they might compensate for lost
Externí odkaz:
https://doaj.org/article/cee7a78f47b5458c87ac726e1a6998d6
Autor:
Harini Natarajan, Shiwei Xu, Andrew R. Crowley, Savannah E. Butler, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Sarah E. Benner, Ruchee Shrestha, Olivia Ajayi, Wendy Wieland-Alter, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A. R. Tobian, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman
Publikováno v:
BMC Immunology, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. Methods We employ machine le
Externí odkaz:
https://doaj.org/article/034c463115724341925f58490be90688
Autor:
Andrew R Crowley, Harini Natarajan, Andrew P Hederman, Carly A Bobak, Joshua A Weiner, Wendy Wieland-Alter, Jiwon Lee, Evan M Bloch, Aaron AR Tobian, Andrew D Redd, Joel N Blankson, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Ruth I Connor, Peter F Wright, Margaret E Ackerman
Publikováno v:
eLife, Vol 11 (2022)
Preexisting antibodies to endemic coronaviruses (CoV) that cross-react with SARS-CoV-2 have the potential to influence the antibody response to COVID-19 vaccination and infection for better or worse. In this observational study of mucosal and systemi
Externí odkaz:
https://doaj.org/article/826a75c76cc8454698aa505fa9b13754
Autor:
Harini Natarajan, Andrew R. Crowley, Savannah E. Butler, Shiwei Xu, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Wendy Wieland-Alter, Ruth I. Connor, Peter F. Wright, Sarah E. Benner, Tania S. Bonny, Oliver Laeyendecker, David Sullivan, Shmuel Shoham, Thomas C. Quinn, H. Benjamin Larman, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A. R. Tobian, Margaret E. Ackerman
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Convalescent plasma has been deployed globally as a treatment for COVID-19, but efficacy has been mixed. Better understanding of the antibody characteristics that may contribute to its antiviral effects is important for this intervention as well as o
Externí odkaz:
https://doaj.org/article/06bc9967a2e644a7be0d758babdbd5ad
Autor:
Savannah E. Butler, Andrew R. Crowley, Harini Natarajan, Shiwei Xu, Joshua A. Weiner, Carly A. Bobak, Daniel E. Mattox, Jiwon Lee, Wendy Wieland-Alter, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced va
Externí odkaz:
https://doaj.org/article/9e96a50019a94152ad25988385639e34
Autor:
Carly A, Bobak, Abhimanyu, Harini, Natarajan, Tanmay, Gandhi, Sandra L, Grimm, Tomoki, Nishiguchi, Kent, Koster, Santiago Carrero, Longlax, Qiniso, Dlamini, Jacquiline, Kahari, Godwin, Mtetwa, Jeffrey D, Cirillo, James, O'Malley, Jane E, Hill, Cristian, Coarfa, Andrew R, DiNardo
Publikováno v:
Aging. 14:2174-2193
Tuberculosis (TB) is the archetypical chronic infection, with patients having months of symptoms before diagnosis. In the two years after successful therapy, survivors of TB have a three-fold increased risk of death.Guinea pigs were infected withGuin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf822f7de82bd18dffcf6b09935ea88
https://doi.org/10.18632/aging.203936
https://doi.org/10.18632/aging.203936
Autor:
Simone I Richardson, Amy W Chung, Harini Natarajan, Batsirai Mabvakure, Nonhlanhla N Mkhize, Nigel Garrett, Salim Abdool Karim, Penny L Moore, Margaret E Ackerman, Galit Alter, Lynn Morris
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006987 (2018)
While the induction of broadly neutralizing antibodies (bNAbs) is a major goal of HIV vaccination strategies, there is mounting evidence to suggest that antibodies with Fc effector function also contribute to protection against HIV infection. Here we
Externí odkaz:
https://doaj.org/article/0857d5e8498647c2bd342419e3ec54c3
Autor:
Alec W. Freyn, Caroline Atyeo, Patricia L. Earl, Jeffrey L. Americo, Gwo-Yu Chuang, Harini Natarajan, Tiffany Frey, Jason Gall, Juan I Moliva, Ruth Hunegnaw, Guha Asthagiri Arunkumar, Clinton Ogega, Arshan Nasir, Hamilton Bennett, Joshua Johnson, Michael A. Durney, Guillaume Stewart-Jones, Jay W Hooper, Tonya Colpitts, Galit Alter, Nancy J. Sullivan, Andrea Carfi, Bernard Moss
Monkeypox virus (MPXV) caused a global outbreak in 2022, fueled by behaviorally-altered and enhanced human-to-human transmission. While smallpox vaccines were rapidly deployed to curb spread and disease among those at highest risk, breakthrough disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4530621a23ef6dcac5c8f7cf2e7bd109
https://doi.org/10.1101/2022.12.17.520886
https://doi.org/10.1101/2022.12.17.520886
Autor:
Andrew P. Hederman, Harini Natarajan, Joshua A. Wiener, Peter F. Wright, Evan M. Bloch, Aaron A.R. Tobian, Andrew D. Redd, Joel N. Blankson, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E. Ackerman
Publikováno v:
medRxiv
SARS-CoV-2 variants have continuously emerged even as highly effective vaccines have been widely deployed. Reduced neutralization observed against variants of concern (VOC) raises the question as to whether other antiviral antibody activities are sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cec3afcb5d6fa0678f0df1f7937ccb0
https://doi.org/10.1101/2022.09.15.22280000
https://doi.org/10.1101/2022.09.15.22280000
Autor:
Jacqueline M. Brady, Meredith Phelps, Scott W. MacDonald, Evan C. Lam, Adam Nitido, Dylan Parsons, Christine L. Boutros, Cailin E. Deal, Wilfredo F. Garcia-Beltran, Serah Tanno, Harini Natarajan, Margaret E. Ackerman, Vladimir D. Vrbanac, Alejandro B. Balazs
Publikováno v:
Sci Transl Med
HIV broadly neutralizing antibodies (bNAbs) are capable of both blocking viral entry and driving innate immune responses against HIV-infected cells through their Fc region. Vaccination or productive infection results in a polyclonal mixture of class-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbededc08cc75fe740629bd6948738c
https://europepmc.org/articles/PMC9507259/
https://europepmc.org/articles/PMC9507259/