Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Harinarayanan Janakiraman"'
Critical evaluation of an autologous peripheral blood mononuclear cell-based humanized cancer model.
Autor:
Harinarayanan Janakiraman, Scott A Becker, Alexandra Bradshaw, Mark P Rubinstein, Ernest Ramsay Camp
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273076 (2022)
The use of humanized mouse models for oncology is rapidly expanding. Autologous patient-derived systems are particularly attractive as they can model the human cancer's heterogeneity and immune microenvironment. In this study, we developed an autolog
Externí odkaz:
https://doaj.org/article/6c702c4a6e5e4432842b2a58e8485956
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678ea85076a875cce2ec2a06cbe98002
https://doi.org/10.1158/0008-5472.22409327.v1
https://doi.org/10.1158/0008-5472.22409327.v1
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion of the T cells, and also imprints them with replicative senescence signatures. Our previous studies have shown that life-span and antit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab5bb6628739c77c95eca0e15f38750
https://doi.org/10.1158/0008-5472.c.6507755
https://doi.org/10.1158/0008-5472.c.6507755
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Details for comparative characterization of the phenotype, and anti-tumor function of p53-KO vs Wt T cells is included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863db56b7c51f04bf1d1525be8a10a92
https://doi.org/10.1158/0008-5472.22409330
https://doi.org/10.1158/0008-5472.22409330
Autor:
Harinarayanan Janakiraman, E. Ramsay Camp, Denise I. Garcia, Alexandra Bradshaw, Katie E. Hurst, Cindy Wang
Publikováno v:
Journal of Surgical Research. 264:163-172
Emerging evidence indicates associations between high-fat diet (HFD), metabolic syndrome (MetS), and increased risk of pancreatic cancer. However, individual components of an HFD that increase cancer risk have not been isolated. In addition, a specif
Autor:
Viswanathan Palanisamy, Philip H. Howe, Harinarayanan Janakiraman, Radhika Gudi, Chenthamarakshan Vasu
Publikováno v:
Oncotarget
Higher epidermal growth factor receptor (EGFR) signaling can contribute to tumor metastasis and resistance to therapies in oral squamous cell carcinoma (OSCC). EGFR signaling can promote epithelial-mesenchymal transition (EMT) in OSCC. EMT is a proce
Autor:
Viswanathan Palanisamy, Phillip Howe, Chenthamarakshan Vasu, Radhika Gudi, Mrinmoyee Majumdar, Harinarayanan Janakiraman
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC). Altered epidermal growth factor receptor (EGFR) levels can contribute to tumor metastasis and resistance to therapies. The epithelial-mesenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6b74c8544c35bd90b5e1818851365c
https://doi.org/10.1101/2020.08.05.237107
https://doi.org/10.1101/2020.08.05.237107
Autor:
Reniqua House, Sudha Talwar, Sean M. Courtney, Gary Hardiman, Viswanathan Palanisamy, Harinarayanan Janakiraman, Shikhar Mehrotra, Vamsi K. Gangaraju, Edward S Hazard, Philip H. Howe
Publikováno v:
Oncogene
A well-studied RNA-binding protein Hu Antigen-R (HuR), controls post-transcriptional gene regulation and undergoes stress-activated caspase-3 dependent cleavage in cancer cells. The cleavage products of HuR are known to promote cell death; however, t
Autor:
Brenda J. Hoffman, Victoria J. Findlay, Ernest Ramsay Camp, Emily Curl, Yun Zhu, Cynthia Timmers, Cindy Wang, Elizabeth G. Hill, Graham W. Warren, Ashley W. Cross, Scott A. Becker, David N. Lewin, Harinarayanan Janakiraman
Publikováno v:
International journal of cancerReferences. 147(5)
Progress in rectal cancer therapy has been hindered by the lack of effective disease-specific preclinical models that account for the unique molecular profile and biology of rectal cancer. Thus, we developed complementary patient-derived xenograft (P
Autor:
Pravin Kesarwani, Viswanathan Palanisamy, Kelly Moxley, Shikhar Mehrotra, Anirban Banerjee, Mazen Al-Hommrani, Myroslawa Soloshchenko, Matthew J. Scheffel, Shilpak Chatterjee, Paramita Chakraborty, Mark P. Rubinstein, Kristina Andrijauskaite, Michael I. Nishimura, David J. Cole, Kristi L. Helke, Harinarayanan Janakiraman, Krishnamurthy Thyagarajan, Christina Voelkel-Johnson, Elizabeth-Garrett Mayer, Chrystal M. Paulos, Kent Armenson
Publikováno v:
Cancer Research. 76:5229-5240
Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion of the T cells, and also imprints them with replicative senescence signatures. Our previous studies have shown that life-span and antit