Výsledky vyhledávání - "Harikrishnan Parameswaran"

Akademický článek

MECHANICAL FORCES ACCELERATE COLLAGEN DIGESTION BY BACTERIAL COLLAGENASE IN LUNG TISSUE STRIPS

Autor: Eunice Yi, Susumu Sato, Ayuko Takahashi, Harikrishnan Parameswaran, Todd A Blute, Erzsébet Bartolák-Suki, Bela Suki

Publikováno v: Frontiers in Physiology, Vol 7 (2016)

Most tissues in the body are under mechanical tension, and while enzymes mediate many cellular and extracellular processes, the effects of mechanical forces on enzyme reactions in the native extracellular matrix (ECM) are not fully understood. We hyp

Externí odkaz: https://doaj.org/article/ec4eee9eadb14e9c8df28386136be4dd

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Akademický článek

Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness.

Autor: Justin K Lui, Harikrishnan Parameswaran, Mitchell S Albert, Kenneth R Lutchen

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142738 (2015)

Advancements in hyperpolarized helium-3 MRI (HP 3He-MRI) have introduced the ability to render and quantify ventilation patterns throughout the anatomic regions of the lung. The goal of this study was to establish how ventilation heterogeneity relate

Externí odkaz: https://doaj.org/article/db346cc40ba247bba12912036db8a935

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Akademický článek

Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.

Autor: Harikrishnan Parameswaran, Arnab Majumdar, Béla Suki

Publikováno v: PLoS Computational Biology, Vol 7, Iss 4, p e1001125 (2011)

Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure

Externí odkaz: https://doaj.org/article/1dcfbec57e754888aa6dfee1a11d0a71

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Akademický článek

Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells.

Autor: Masataka Morioka, Harikrishnan Parameswaran, Keiji Naruse, Masashi Kondo, Masahiro Sokabe, Yoshinori Hasegawa, Béla Suki, Satoru Ito

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26384 (2011)

Microtubules are structural components of the cytoskeleton that determine cell shape, polarity, and motility in cooperation with the actin filaments. In order to determine the role of microtubules in cell alignment, human airway smooth muscle cells w

Externí odkaz: https://doaj.org/article/93cd864795464c1bac47ebc690779951

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Stiffening of the extracellular matrix is a sufficient condition for airway hyperreactivity

Autor: Caroline A McCormick, Harikrishnan Parameswaran, Suzanne E Stasiak, Ralston D Augspurg, Jeffrey W. Ruberti, Ryan R. Jamieson, Samuel R. Polio

Publikováno v: J Appl Physiol (1985)

The current therapeutic approach to asthma focuses exclusively on targeting inflammation and reducing airway smooth muscle force to prevent the recurrence of symptoms. However, even when inflammation is brought under control, airways in an asthmatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0e9a7bf3337e51d495e3bca23b2324
https://doi.org/10.1152/japplphysiol.00554.2020

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Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity

Autor: Suzanne E Stasiak, Ryan R. Jamieson, Harikrishnan Parameswaran, Jeffrey W. Ruberti, Samuel R. Polio

The current therapeutic approach to asthma focuses exclusively on targeting inflammation and reducing airway smooth muscle force in an effort to prevent the recurrence of symptoms. However, the treatment is not a cure and has little beneficial effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8501258c739e8722228a2ea768b9d4b5
https://doi.org/10.1101/2020.06.27.175687

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