Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Harikrishnan LS"'
Autor:
Tajudheen Karatt, Mary-Ellen Cvijic, Neil T. Burford, Jing Chen, Kumaragurubaran K, Christopher B. Cooper, Arvind Mathur, Lalgudi S. Harikrishnan, Lauren E. Kayser, Sukhen Karmakar, Neelam Srivastava, Tai W. Wong, Yan Kong, George L. Trainor, Amrita Roy, Michael A. Poss, David S. Nirschl, Anuradha Gupta
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(6)
Identification, synthesis and structure-activity relationship of small-molecule VIPR1 antagonists encompassing two chemical series are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3daa503a9274f44b1fce4af7cec0292
https://pubmed.ncbi.nlm.nih.gov/22365758
https://pubmed.ncbi.nlm.nih.gov/22365758
Autor:
Li Z; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Harikrishnan LS; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Xu G; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Samanta D; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Clemente JC; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Leng L; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States., Tu W; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States., Yang L; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States., Huang L; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States., Wang M; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States., Wang S; Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Pharmacology, Medical School, University of Michigan, Ann Arbor, Michigan 48109, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States., Deng Q; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Behshad E; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Nagilla R; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Orth P; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Rice C; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Strickland C; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Mohammad HP; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Priestley ES; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States., Sui Z; SK Life Science Labs, 2500 Renaissance Blvd, King of Prussia, Pennsylvania 19406, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.
Autor:
Kempson J; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Zhang H; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Hou X; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Cornelius L; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Zhao R; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Wang B; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Hong Z; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Oderinde MS; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Pawluczyk J; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Wu DR; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Sun D; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Li P; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Yip S; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Smith A; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Caceres-Cortes J; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Aulakh D; Materials Science & Engineering, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States., Sarjeant AA; Materials Science & Engineering, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States., Park PK; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Harikrishnan LS; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Qin LY; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Dodd DS; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Fink B; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Vite G; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States., Mathur A; Research and Early Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
Publikováno v:
The Journal of organic chemistry [J Org Chem] 2021 Jul 02; Vol. 86 (13), pp. 8851-8861. Date of Electronic Publication: 2021 Jun 14.
Autor:
Ruan Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA. Electronic address: zheming.ruan@bms.com., Park PK; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Wei D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Purandare A; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Wan H; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., O'Malley D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Stachura S; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Perez H; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Cavallaro CL; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Weigelt CA; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Sack JS; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Ruzanov M; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Khan J; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Gururajan M; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Wong JJ; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Huang Y; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Yarde M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Li Z; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Chen C; Preclinical Candidate Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Sun H; Preclinical Candidate Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Borowski V; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Xie JH; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Anthony M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Agler M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Fink BE; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Harikrishnan LS; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Mar 01; Vol. 35, pp. 127778. Date of Electronic Publication: 2021 Jan 08.
Autor:
Harikrishnan LS; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA. Electronic address: lalgudi.harikrishnan@bms.com., Gill P; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Kamau MG; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Qin LY; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Ruan Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., O'Malley D; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Huynh T; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Stachura S; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Cavallaro CL; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Lu Z; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., J-W Duan J; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Weigelt CA; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Sack JS; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Ruzanov M; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Khan J; Molecular Structure & Design, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Gururajan M; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Wong JJ; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Huang Y; Immuno-Oncology Small Molecule Biology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Yarde M; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Li Z; Lead Discovery & Optimization, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Chen C; Preclinical Candidate Optimization, MAP, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Sun H; Preclinical Candidate Optimization, MAP, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Borowski V; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Murtaza A; In vivo Pharmacology, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Fink BE; Department of Chemistry, Bristol Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Jun 15; Vol. 30 (12), pp. 127204. Date of Electronic Publication: 2020 Apr 20.
Autor:
Finlay HJ; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Jiang J; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Rampulla R; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Salvati ME; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Qiao JX; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wang TC; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Lawrence RM; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Harikrishnan LS; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Kamau MG; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Taylor DS; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Chen AYA; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Yin X; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Huang CS; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Chang M; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Chen XQ; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Sleph PG; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Xu C; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Li J; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Levesque P; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Adam LP; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wexler RR; Departments of Discovery Chemistry, Biology, Preclinical Candidate Optimization, Pharmaceutics, and Bioanalytical Sciences, Bristol-Myers Squibb, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 May 06; Vol. 10 (6), pp. 911-916. Date of Electronic Publication: 2019 May 06 (Print Publication: 2019).
Autor:
Harikrishnan LS; Department of Chemistry, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA. Electronic address: lalgudi.harikrishnan@bms.com., Warrier J; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Tebben AJ; Molecular Structure & Design, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Tonukunuru G; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Madduri SR; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Baligar V; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Mannoori R; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Seshadri B; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Rahaman H; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Arunachalam PN; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Dikundwar AG; BBRC, Special Economic Zone, Biocon Park, Jigani Link Road, Bangalore, India., Fink BE; Department of Chemistry, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Fargnoli J; Immuno-Oncology Small Molecule Biology, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Fereshteh M; Lead Discovery & Optimization, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Fan Y; Lead Discovery & Optimization, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Lippy J; Lead Discovery & Optimization, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Ho CP; Immuno-Oncology Small Molecule Biology, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Wautlet B; Immuno-Oncology Small Molecule Biology, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Sheriff S; Molecular Structure & Design, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Ruzanov M; Molecular Structure & Design, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA., Borzilleri RM; Department of Chemistry, Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, NJ, USA.
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Mar 01; Vol. 26 (5), pp. 1026-1034. Date of Electronic Publication: 2018 Jan 31.
Autor:
Qiao JX; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Wang TC; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Adam LP; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Chen AY; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Taylor DS; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Yang RZ; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Zhuang S; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Sleph PG; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Li JP; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Li D; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Yin X; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Chang M; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Chen XQ; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Shen H; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Li J; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Smith D; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Wu DR; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Leith L; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Harikrishnan LS; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Kamau MG; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Miller MM; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Bilder D; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Rampulla R; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Li YX; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Xu C; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Lawrence RM; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Poss MA; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Levesque P; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Gordon DA; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Huang CS; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Finlay HJ; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Wexler RR; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Salvati ME; Departments of †Discovery Chemistry, ‡Discovery Biology, §Discovery Toxicology, ∥Preclinical Candidate Optimization, and ⊥Pharmaceutics, Bristol-Myers Squibb Company, Research and Development , P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2015 Nov 25; Vol. 58 (22), pp. 9010-26. Date of Electronic Publication: 2015 Nov 17.
Autor:
Wang Y; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA. Electronic address: yufeng.wang@bms.com., Yang W; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Finlay HJ; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Harikrishnan LS; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Jiang J; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Kamau MG; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Van Kirk K; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Nirschl DS; Synthesis & Analysis Technology Team, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Taylor DS; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Chen AY; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Yin X; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Sleph PG; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Yang RZ; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Huang CS; Department of Preclinical Candidate Optimization, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Adam LP; Department of Biology, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Lawrence RM; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Wexler RR; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA., Salvati ME; Department of Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543-4000, USA.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Feb 01; Vol. 24 (3), pp. 860-4. Date of Electronic Publication: 2014 Jan 06.
Autor:
Harikrishnan LS; Department of Chemistry, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, USA. Lalgudi.Harikrishnan@bms.com, Finlay HJ, Qiao JX, Kamau MG, Jiang J, Wang TC, Li J, Cooper CB, Poss MA, Adam LP, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Sitkoff DF, Galella MA, Nirschl DS, Van Kirk K, Miller AV, Huang CS, Chang M, Chen XQ, Salvati ME, Wexler RR, Lawrence RM
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2012 Jul 12; Vol. 55 (13), pp. 6162-75. Date of Electronic Publication: 2012 Jun 22.