Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hariharasubramanian Ramakrishnan"'
Autor:
Hariharasubramanian Ramakrishnan, Stewart A Bloomfield, Suresh Viswanathan, Sandeep Kumar, Abram Akopian
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We examined structural and functional changes in the outer retina of a mouse model of glaucoma. We examined whether these changes are a secondary consequence of damage in the inner retina and whether neuroprotection of the inner retina also p
Autor:
Stewart A. Bloomfield, Kaushambi Roy, Suresh Viswanathan, Hariharasubramanian Ramakrishnan, Sandeep Kumar, Abram Akopian
Publikováno v:
Journal of Clinical Investigation. 127:2647-2661
The progressive death of retinal ganglion cells and resulting visual deficits are hallmarks of glaucoma, but the underlying mechanisms remain unclear. In many neurodegenerative diseases, cell death induced by primary insult is followed by a wave of s
Autor:
Stewart A Bloomfield, Tamas Atlasz, Feng Pan, Yi Zhang, Hariharasubramanian Ramakrishnan, Kaushambi Roy, Abduqodir Toychiev, Béla Völgyi, Abram Akopian
Publikováno v:
The Journal of Physiology. 594:6679-6699
KEY POINTS Retinal ganglion cells (RGCs) in dark-adapted retinas show a range of threshold sensitivities spanning ∼3 log units of illuminance. Here, we show that the different threshold sensitivities of RGCs reflect an inhibitory mechanism that mas
Autor:
Hariharasubramanian Ramakrishnan, Sandeep Kumar, Abram Akopian, Suresh Viswanathan, Stewart A Bloomfield
Publikováno v:
Journal of Comparative Neurology. 527:159-173
We determined whether the structural and functional integrity of amacrine cells (ACs), the largest cohort of neurons in the mammalian retina, are affected in glaucoma. Intraocular injection of microbeads was made in mouse eyes to elevate intraocular
Autor:
Jian J. Li, Anuradha Dhingra, Noga Vardi, Shanti R. Tummala, Hariharasubramanian Ramakrishnan, Marie E. Fina
Publikováno v:
European Journal of Neuroscience. 43:1509-1522
Heterotrimeric G-proteins couple metabotropic receptors to downstream effectors. In retinal ON bipolar cells, Go couples the metabotropic receptor mGluR6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell. Light, via GTPase
Autor:
Marie E. Fina, Arkady Lyubarsky, Noga Vardi, Hariharasubramanian Ramakrishnan, Shanti R. Tummala, Anuradha Dhingra, Jian J. Li
Publikováno v:
The Journal of Physiology. 593:1531-1550
Heterotrimeric G-proteins (comprising Gα and Gβγ subunits) are critical for coupling of metabotropic receptors to their downstream effectors. In the retina, glutamate released from photoreceptors in the dark activates metabotropic glutamate recept
Autor:
Anuradha Dhingra, Marie E. Fina, Hariharasubramanian Ramakrishnan, Ying Xu, Noga Vardi, Pyroja Sulaiman, Shanti R. Tummala
Publikováno v:
Journal of Biological Chemistry. 288:7420-7429
Kir2.4, a strongly rectifying potassium channel that is localized to neurons and is especially abundant in retina, was fished with yeast two-hybrid screen using a constitutively active Gαo1. Here, we wished to determine whether and how Gαo affects
Autor:
Abram, Akopian, Sandeep, Kumar, Hariharasubramanian, Ramakrishnan, Suresh, Viswanathan, Stewart A, Bloomfield
Publikováno v:
The Journal of comparative neurology. 527(1)
We determined whether the structural and functional integrity of amacrine cells (ACs), the largest cohort of neurons in the mammalian retina, are affected in glaucoma. Intraocular injection of microbeads was made in mouse eyes to elevate intraocular
Publikováno v:
Journal of Neurochemistry. 117:812-823
Recently, we demonstrated that mRNA for the neuronal glutamate transporter, excitatory amino acid carrier 1 (EAAC1), is found in dendrites of hippocampal neurons in culture and in dendrites of hippocampal pyramidal cells after pilocarpine-induced sta
Autor:
Volkmar Gieselmann, Kerstin Khalaj Hedayati, Hariharasubramanian Ramakrishnan, Hans-Hilmar Goebel, Renate Lüllmann-Rauch, Simon Ngamli Fewou, Matthias Eckhardt, Carsten Wessig, Helena Maier
Publikováno v:
The Journal of Neuroscience. 27:9482-9490
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system a