Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Hariharan, Subramanian"'
Autor:
Andrew Chang, Sravya Prabhala, Ali Daneshkhah, Jianan Lin, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7 to 8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by
Externí odkaz:
https://doaj.org/article/42860204b9af41e0bf13ac1109134cdb
Autor:
Laura Keil, Filip Berisha, Stella Ritter, Johanna Skibowski, Hariharan Subramanian, Viacheslav O. Nikolaev, Christian Kubisch, Rixa Woitschach, Larissa Fabritz, Raphael Twerenbold, Stefan Blankenberg, Sören Weidemann, Tanja Zeller, Paulus Kirchhof, Daniel Reichart, Christina Magnussen
Publikováno v:
ESC Heart Failure, Vol 11, Iss 1, Pp 541-549 (2024)
Abstract Aims Cardiomyopathies (CMPs) are a heterogeneous group of diseases that are defined by structural and functional abnormalities of the cardiac muscle. Dilated cardiomyopathy (DCM), the most common CMP, is defined by left ventricular dilation
Externí odkaz:
https://doaj.org/article/dfb52136a4494daba8ed13b44b407a32
Autor:
Mohindar M. Karunakaran, Hariharan Subramanian, Yiming Jin, Fiyaz Mohammed, Brigitte Kimmel, Claudia Juraske, Lisa Starick, Anna Nöhren, Nora Länder, Carrie R. Willcox, Rohit Singh, Wolfgang W. Schamel, Viacheslav O. Nikolaev, Volker Kunzmann, Andrew J. Wiemer, Benjamin E. Willcox, Thomas Herrmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg
Externí odkaz:
https://doaj.org/article/f44499b1682d4024855a409410410b01
Autor:
Ali Daneshkhah, Sravya Prabhala, Parvathi Viswanathan, Hariharan Subramanian, Jianan Lin, Andrew S Chang, Ankit Bharat, Hemant Kumar Roy, Vadim Backman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Supranucleosomal chromatin structure, including chromatin domain conformation, is involved in the regulation of gene expression and its dysregulation has been associated with carcinogenesis. Prior studies have shown that cells in the buccal
Externí odkaz:
https://doaj.org/article/15ecb9fa213d4cdcaba6bc61a8c144db
Autor:
Axel E. Kraft, Nadja I. Bork, Hariharan Subramanian, Nikoleta Pavlaki, Antonio V. Failla, Bernd Zobiak, Marco Conti, Viacheslav O. Nikolaev
Publikováno v:
Cells, Vol 13, Iss 6, p 476 (2024)
The ubiquitous second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains. Phosphodiesterase subfamilies 4B and 4D are critically involved
Externí odkaz:
https://doaj.org/article/c82bc06ba3af4c549615d0745de94c45
Autor:
Nadja I. Bork, Hariharan Subramanian, Roberta Kurelic, Viacheslav O. Nikolaev, Sergei D. Rybalkin
Publikováno v:
Cells, Vol 12, Iss 23, p 2759 (2023)
In mouse cardiomyocytes, the expression of two subfamilies of the calcium/calmodulin-regulated cyclic nucleotide phosphodiesterase 1 (PDE1)—PDE1A and PDE1C—has been reported. PDE1C was found to be the major subfamily in the human heart. It is a d
Externí odkaz:
https://doaj.org/article/967ec040c9a0430598da454e5595e101
Autor:
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev
Publikováno v:
Cells, Vol 12, Iss 11, p 1543 (2023)
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isofo
Externí odkaz:
https://doaj.org/article/c301bbb2157d47f39041d05dc51f0267
Publikováno v:
Cells, Vol 12, Iss 3, p 436 (2023)
The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper f
Externí odkaz:
https://doaj.org/article/418f980e386b42388f47cbc29c8f326f
Autor:
Hariharan Subramanian, Satyen Parida, Chitra Rajeswari Thangaswamy, Ashok Shankar Badhe, B V Sai Chandran, Sandeep Kumar Mishra
Publikováno v:
Annals of Cardiac Anaesthesia, Vol 23, Iss 4, Pp 453-459 (2020)
Context: We studied the relationship between intraoperative transesophageal echocardiography-derived (TEE-derived) pulmonary artery systolic pressure (PASP) measurements with early morbidity in on-pump coronary artery bypass grafting (CABG) surgery.
Externí odkaz:
https://doaj.org/article/3b38067503804ac39ff190fbac8e5660
Autor:
Hariharan Subramanian, Tanwir Hashem, Devika Bahal, Ananth K. Kammala, Kanedra Thaxton, Rupali Das
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Asthma prevalence has increased considerably over the decades and it is now considered as one of the most common chronic disorders in the world. While the current anti-asthmatic therapies are effective for most asthma patients, there are 5-10% subjec
Externí odkaz:
https://doaj.org/article/a2bcef97ba474193aff4479f7b8ad153