Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury

Autor: Vivekkumar P. Dadhania, Bharat Bhushan, Udayan Apte, Harihara M. Mehendale

Publikováno v: Dose-Response, Vol 15 (2017)

Preplacement of compensatory tissue repair (CTR) by exposure to a nonlethal dose of a toxicant protects animals against a lethal dose of another toxicant. Although CTR is known to heteroprotect, the underlying molecular mechanisms are not completely

Externí odkaz: https://doaj.org/article/95eb0ce414094870ac25f8ac0d0157df

Biochemical Mechanisms of Biphasic Dose-Response Relationships: Role of Hormesis

Autor: Harihara M. Mehendale

Publikováno v: Biological Effects of Low Level Exposures to Chemicals and Radiation ISBN: 9781315150284
Biological Effects of Low Level Exposures to Chemicals and Radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4edefba41756c1842a38b60e58471f48
https://doi.org/10.1201/9781315150284-4

Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2

Autor: Shashikiran Donthamsetty, Vishakha S. Bhave, John R. Latendresse, Harihara M. Mehendale, Michael L. Cunningham

Publikováno v: Toxicology and Applied Pharmacology. 251:173-180

We have previously reported that among the other death proteins, hepatic secretory phospholipase A{sub 2} (sPLA{sub 2}) is a leading mediator of progression of liver injury initiated by CCl{sub 4} in rats. The aim of our present study was to test the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67fe58b504483b5b10a0925dd0172d0b
https://doi.org/10.1016/j.taap.2011.01.013

High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity

Autor: Brent White, Mayurranjan S. Mitra, Shashikiran Donthamsetty, Harihara M. Mehendale

Publikováno v: Toxicology and Applied Pharmacology. 231:413-422

Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d43422960146f38b3a8bd177f6ec41
https://doi.org/10.1016/j.taap.2008.05.006

Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARα with clofibrate

Autor: Vishakha S. Bhave, Harihara M. Mehendale, John R. Latendresse, Shashikiran Donthamsetty, Mayurranjan S. Mitra

Publikováno v: Toxicology and Applied Pharmacology. 230:327-337

The objective was to investigate if the hepatotoxic sensitivity in nonalcoholic steatohepatitic mice to acetaminophen (APAP) is due to downregulation of nuclear receptor PPARalpha via lower cell division and tissue repair. Male Swiss Webster mice fed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7f4b9beac5dc5cd9a27740fe1d9fff
https://doi.org/10.1016/j.taap.2008.02.031