In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.

Autor: Chen X; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Haribowo AG; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Baik AH; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, Division of Cardiology, University of California San Francisco, San Francisco, CA, USA., Fossati A; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Stevenson E; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Chen YR; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA., Reyes NS; Department of Medicine and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA., Peng T; Department of Medicine and Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA.; Bakar Aging Research Institute, University of California San Francisco, San Francisco, CA, USA., Matthay MA; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Departments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA., Traglia M; Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA., Pico AR; Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA., Jarosz DF; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.; Department of Developmental Biology, Stanford University, CA, USA., Buchwalter A; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Physiology, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Ghaemmaghami S; Mass Spectrometry Resource Laboratory, University of Rochester, Rochester, NY, USA.; Department of Biology, University of Rochester, Rochester, NY, USA., Swaney DL; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Jain IH; Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; Bakar Aging Research Institute, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.

Publikováno v: Science advances [Sci Adv] 2023 Dec 08; Vol. 9 (49), pp. eadj4884. Date of Electronic Publication: 2023 Dec 08.

Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.

Autor: Midha AD; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Zhou Y; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA., Queliconi BB; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA., Barrios AM; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA., Haribowo AG; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA., Chew BTL; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA; Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA., Fong COY; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA., Blecha JE; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA., VanBrocklin H; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA., Seo Y; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA., Jain IH; Gladstone Institutes, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: isha.jain@gladstone.ucsf.edu.

Publikováno v: Cell metabolism [Cell Metab] 2023 Mar 07; Vol. 35 (3), pp. 504-516.e5.

1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.

Autor: Hannich JT; Department of Biochemistry, University of Geneva, Geneva, Switzerland.; Swiss National Center of Competence in Research (NCCR) 'Chemical Biology', Geneva, Switzerland., Haribowo AG; Department of Biochemistry, University of Geneva, Geneva, Switzerland.; Swiss National Center of Competence in Research (NCCR) 'Chemical Biology', Geneva, Switzerland., Gentina S; Department of Cell Biology, University of Geneva, Geneva, Switzerland., Paillard M; CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Bron, France., Gomez L; CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Bron, France., Pillot B; CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Bron, France., Thibault H; CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Bron, France., Abegg D; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA., Guex N; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland.; Bioinformatics Competence Center, University of Lausanne, Lausanne, Switzerland., Zumbuehl A; Swiss National Center of Competence in Research (NCCR) 'Chemical Biology', Geneva, Switzerland.; Department of Chemistry, University of Fribourg, Fribourg, Switzerland., Adibekian A; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA., Ovize M; CarMeN Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Bron, France., Martinou JC; Department of Cell Biology, University of Geneva, Geneva, Switzerland., Riezman H; Department of Biochemistry, University of Geneva, Geneva, Switzerland. howard.riezman@unige.ch.; Swiss National Center of Competence in Research (NCCR) 'Chemical Biology', Geneva, Switzerland. howard.riezman@unige.ch.

Publikováno v: Nature metabolism [Nat Metab] 2019 Oct; Vol. 1 (10), pp. 996-1008. Date of Electronic Publication: 2019 Oct 14.