Zobrazeno 1 - 10
of 2 652
pro vyhledávání: '"Haribabu A"'
Autor:
Eiji Obayashi, Rafael E. Luna, Takashi Nagata, Pilar Martin-Marcos, Hiroyuki Hiraishi, Chingakham Ranjit Singh, Jan Peter Erzberger, Fan Zhang, Haribabu Arthanari, Jacob Morris, Riccardo Pellarin, Chelsea Moore, Ian Harmon, Evangelos Papadopoulos, Hisashi Yoshida, Mahmoud L. Nasr, Satoru Unzai, Bryttney Thompson, Eric Aube, Samantha Hustak, Florian Stengel, Eddie Dagraca, Asokan Ananbandam, Philip Gao, Takeshi Urano, Alan G. Hinnebusch, Gerhard Wagner, Katsura Asano
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114404- (2024)
Externí odkaz:
https://doaj.org/article/0abf4580bb9d47ceb45f9407f4e57f48
Autor:
Han Chen, Ming F Lye, Christoph Gorgulla, Scott B Ficarro, Gregory D Cuny, David A Scott, Fan Wu, Paul W Rothlauf, Xiaoou Wang, Rosio Fernandez, Jean M Pesola, Sorin Draga, Jarrod A Marto, James M Hogle, Haribabu Arthanari, Donald M Coen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011781 (2023)
Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress complex (NEC) composed of two subunits, UL50 and UL53, whose interaction is crucial for viral rep
Externí odkaz:
https://doaj.org/article/de5854a14a0246dc98346d4f72583da0
Autor:
Giacomo G. Rossetti, Marianna A. Ossorio, Stephan Rempel, Annika Kratzel, Vasilis S. Dionellis, Samia Barriot, Laurence Tropia, Christoph Gorgulla, Haribabu Arthanari, Volker Thiel, Peter Mohr, Remo Gamboni, Thanos D. Halazonetis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Mpro, the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is essential for the viral life cycle. Accordingly, several groups have performed in silico screens to identify Mpro inhibitors that might be used t
Externí odkaz:
https://doaj.org/article/422fbb10202b48f599c596a21a945a4e
Autor:
Hwan Bae, Thibault Viennet, Eunyoung Park, Nam Chu, Antonieta Salguero, Michael J Eck, Haribabu Arthanari, Philip A Cole
Publikováno v:
eLife, Vol 11 (2022)
Akt is a Ser/Thr protein kinase that plays a central role in metabolism and cancer. Regulation of Akt’s activity involves an autoinhibitory intramolecular interaction between its pleckstrin homology (PH) domain and its kinase domain that can be rel
Externí odkaz:
https://doaj.org/article/7eb0ca8ae8d64ce98811c3b52aefc3c7
Quantum computers promise to solve computational problems significantly faster than classical computers. These 'speed-ups' are achieved by utilizing a resource known as magic. Measuring the amount of magic used by a device allows us to quantify its p
Externí odkaz:
http://arxiv.org/abs/2408.01663
Autor:
Soumya P. Behera, Abhinav Dubey, Wan-Na Chen, Viviane S. De Paula, Meng Zhang, Nikolaos G. Sgourakis, Wolfgang Bermel, Gerhard Wagner, Paul W. Coote, Haribabu Arthanari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
The structure and dynamics of large proteins and complexes can be studied by methyl-NMR but resonance assignment is still challenging. Here, the authors present a NMR method that leverages optimal control pulse design to unambiguously distinguish bet
Externí odkaz:
https://doaj.org/article/6d3ce66bd2fb4ffa8c649ac9c398510f
Autor:
Isabel A. Calvo, Shalini Sharma, Joao A. Paulo, Alexander O.D. Gulka, Andras Boeszoermenyi, Jingyu Zhang, Jose M. Lombana, Christina M. Palmieri, Laura A. Laviolette, Haribabu Arthanari, Othon Iliopoulos, Steven P. Gygi, Mo Motamedi
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103338- (2021)
Summary: The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth. Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, whic
Externí odkaz:
https://doaj.org/article/4fe5db4627e54e2a8a995599fe937e78
Autor:
Christoph Gorgulla, Krishna M. Padmanabha Das, Kendra E. Leigh, Marco Cespugli, Patrick D. Fischer, Zi-Fu Wang, Guilhem Tesseyre, Shreya Pandita, Alec Shnapir, Anthony Calderaio, Minko Gechev, Alexander Rose, Noam Lewis, Colin Hutcheson, Erez Yaffe, Roni Luxenburg, Henry D. Herce, Vedat Durmaz, Thanos D. Halazonetis, Konstantin Fackeldey, J.J. Patten, Alexander Chuprina, Igor Dziuba, Alla Plekhova, Yurii Moroz, Dmytro Radchenko, Olga Tarkhanova, Irina Yavnyuk, Christian Gruber, Ryan Yust, Dave Payne, Anders M. Näär, Mark N. Namchuk, Robert A. Davey, Gerhard Wagner, Jamie Kinney, Haribabu Arthanari
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102021- (2021)
Summary: The unparalleled global effort to combat the continuing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising prophylactic measures. However, a need still exists for cheap, effecti
Externí odkaz:
https://doaj.org/article/d7b4d74b88b34214a7c03352f3a44144
Autor:
Nam Chu, Thibault Viennet, Hwan Bae, Antonieta Salguero, Andras Boeszoermenyi, Haribabu Arthanari, Philip A Cole
Publikováno v:
eLife, Vol 9 (2020)
Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieved by C-tail ph
Externí odkaz:
https://doaj.org/article/1a4184881e874c57acdc091b3dce4ba7
Autor:
Paul W. Coote, Scott A. Robson, Abhinav Dubey, Andras Boeszoermenyi, Mengxia Zhao, Gerhard Wagner, Haribabu Arthanari
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Bloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution
Externí odkaz:
https://doaj.org/article/cbceedd19fe04e49a3cca526a7eddfc5