Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hari priya Vemana"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102292- (2024)
Patients suffering from BRAF mutant melanoma have tumor recurrence within merely 7 months of treatment with a potent BRAF inhibitor (BRAFi) like vemurafenib. It has been proven that diverse molecular pathways driving BRAFi resistance converge to acti
Externí odkaz:
https://doaj.org/article/24f54a3de91540fbbc9a798eb30be707
Publikováno v:
Heliyon, Vol 8, Iss 1, Pp e08702- (2022)
This research deals with the development of asialoglycoprotein receptors (ASGPR) directed nanoliposomes incorporating a novel BRD4 (Bromodomain-containing protein 4) protein-targeted PROTAC (Proteolysis Targeting Chimera), ARV-825 (ARV) (GALARV), and
Externí odkaz:
https://doaj.org/article/c06bc4448d5d46efbe3ca4422c9ccaf6
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119363 (2015)
We have recently shown that IKK complex plays an important non-genomic role in platelet function, i.e., regulates SNARE machinery-dependent membrane fusion. In this connection, it is well known that MALT1, whose activity is modulated by proteasome, p
Externí odkaz:
https://doaj.org/article/292d50318ef74a53857c616958523653
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125764 (2015)
While calcium signaling is known to play vital roles in platelet function, the mechanisms underlying its receptor-operated calcium entry component (ROCE) remain poorly understood. It has been proposed, but never proven in platelets, that the canonica
Externí odkaz:
https://doaj.org/article/33fb2353d84c462f8352b3b76816ed70
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87026 (2014)
There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states. This seroto
Externí odkaz:
https://doaj.org/article/404a2a1bbd4447abbb69de6b7d9b09b5
Autor:
Anjali Yadav, Ali Alnakhli, Hari Priya Vemana, Shraddha Bhutkar, Aaron Muth, Vikas V. Dukhande
Publikováno v:
Pharm Res
PURPOSE: Glioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%. Current treatment strategies for GBM include surgery, radiation, and chemotherapy. Major challenges in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf335f6be8af1976b7cb3624da17f20
https://doi.org/10.1007/s11095-022-03399-4
https://doi.org/10.1007/s11095-022-03399-4
Autor:
Hari Priya Vemana, Vikas V Dukhande
Publikováno v:
Nanomedicine (Lond)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05c876f639ff45fe8ecb2f1df875934
https://doi.org/10.2217/nnm-2021-0338
https://doi.org/10.2217/nnm-2021-0338
Autor:
Shrikant Barot, Olivia J. Stephenson, Hari Priya Vemana, Anjali Yadav, Shraddha Bhutkar, Louis D. Trombetta, Vikas V. Dukhande
Publikováno v:
Biochem Pharmacol
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths. There is an urgent need for new targets to treat HCC due to limited treatment options and drug resistance. Many cancer cells are known to have high amount of glycog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e75cc3e1aa4cb719e5466623c8402
https://europepmc.org/articles/PMC10039449/
https://europepmc.org/articles/PMC10039449/
Publikováno v:
Nanomedicine. 16:1081-1095
Aim: To develop novel cationic liposomes as a nonviral gene delivery vector for the treatment of rare diseases, such as Lafora disease – a neurodegenerative epilepsy. Materials & methods: DLinDMA and DOTAP liposomes were formulated and characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35cd6a19ed246a064a9b1bd59151c9b3
https://doi.org/10.2217/nnm-2020-0477
https://doi.org/10.2217/nnm-2020-0477