Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Hari Venugopal"'
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02
Autor:
Francois Moreau, Nicholas S. Kirk, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal, Michael C. Lawrence, Veronica Jimenez, Fatima Bosch, John J. Kopchick, Richard D. DiMarchi, Emrah Altindis, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R
Externí odkaz:
https://doaj.org/article/bfab9e0851234eeaa306dca00cc42caa
Autor:
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J. Belousoff, Hari Venugopal, Tin T. Truong, Alisa Glukhova, Andrew N. Keller, Karen J. Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A. Reynolds, Peishen Zhao, Patrick M. Sexton, Denise Wootten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by
Externí odkaz:
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001295 (2021)
G protein-coupled receptors (GPCRs) are critical regulators of cellular function acting via heterotrimeric G proteins as their primary transducers with individual GPCRs capable of pleiotropic coupling to multiple G proteins. Structural features gover
Externí odkaz:
https://doaj.org/article/74d05cb5885440089e6bbe22f303c143
Autor:
Rhys Grinter, Ashleigh Kropp, Hari Venugopal, Moritz Senger, Jack Badley, Princess R. Cabotaje, Ruyu Jia, Zehui Duan, Ping Huang, Sven T. Stripp, Christopher K. Barlow, Matthew Belousoff, Hannah S. Shafaat, Gregory M. Cook, Ralf B. Schittenhelm, Kylie A. Vincent, Syma Khalid, Gustav Berggren, Chris Greening
Publikováno v:
Nature. 615:541-547
Diverse aerobic bacteria use atmospheric H2 as an energy source for growth and survival1. This globally significant process regulates the composition of the atmosphere, enhances soil biodiversity and drives primary production in extreme environments2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ffeadedd60d406ec403e0bbc1d49a4
https://doi.org/10.1038/s41586-023-05781-7
https://doi.org/10.1038/s41586-023-05781-7
Autor:
Shuo Zhang, Gediminas Gervinskas, Shi Qiu, Hari Venugopal, Ross K. W. Marceau, Alex de Marco, Jian Li, Jing Fu
Publikováno v:
Nano Letters. 22:6501-6508
New high-resolution imaging methods for biological samples such as atom probe tomography (APT), facilitated by the invention of laser-pulsed atom probes and cryo-transfer procedures, have recently emerged. However, ensuring the vitreous state of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7abb7c42f95ec4e1306e8adaf862f0
https://doi.org/10.1021/acs.nanolett.2c01495
https://doi.org/10.1021/acs.nanolett.2c01495
Autor:
Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon
Publikováno v:
Nature Structural & Molecular Biology. 29:767-773
P-Rex (PI(3,4,5)P3-dependent Rac exchanger) guanine nucleotide exchange factors potently activate Rho GTPases. P-Rex guanine nucleotide exchange factors are autoinhibited, synergistically activated by Gβγ and PI(3,4,5)P3 binding and dysregulated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4933da63b86a93b7d7d691f3041d1107
https://doi.org/10.1038/s41594-022-00804-9
https://doi.org/10.1038/s41594-022-00804-9
Autor:
Lachlan Clydesdale, Hari Venugopal, Peishen Zhao, Patrick M. Sexton, Alisa Glukhova, Arthur Christopoulos, Christopher A. Reynolds, Yi Lynn Liang, Xin Zhang, Tin T. Truong, Andrew N. Keller, Maryam Khoshouei, Matthew J. Belousoff, Karen J. Gregory, Giuseppe Deganutti, Radostin Danev, Denise Wootten, Katie Leach
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications
Nature Communications
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5aa9dcac923a091ce55a4b69969de5
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
Christopher J. Lupton, Charles Bayly-Jones, Laura D’Andrea, Cheng Huang, Ralf B. Schittenhelm, Hari Venugopal, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon
Publikováno v:
Nature Structural & Molecular Biology. 28:982-988
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1230e71180614c37186a9c968d5591ab
https://doi.org/10.1038/s41594-021-00687-2
https://doi.org/10.1038/s41594-021-00687-2
Autor:
Rhys Grinter, Ashleigh Kropp, Hari Venugopal, Moritz Senger, Jack Badley, Princess Cabotaje, Sven T. Stripp, Christopher K. Barlow, Matthew Belousoff, Gregory M. Cook, Kylie A. Vincent, Ralf B. Schittenhelm, Syma Khalid, Gustav Berggren, Chris Greening
Diverse aerobic bacteria use atmospheric H2as an energy source for growth and survival. This recently discovered yet globally significant process regulates the composition of the atmosphere, enhances soil biodiversity, and drives primary production i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ee4823a41b313b8436b3d75b720853
https://doi.org/10.1101/2022.10.09.511488
https://doi.org/10.1101/2022.10.09.511488
