Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Hari Manev"'
Autor:
Svetlana Dzitoyeva, Hari Manev
Publikováno v:
Journal of Lipids, Vol 2013 (2013)
In exploring the utility of double-stranded RNA (dsRNA) injections for silencing the PAR-domain protein 1 (Pdp1) gene in adult Drosophila, we noticed a dramatic loss of fat tissue lipids. To verify that our RNAi approach produced the expected Pdp1 kn
Externí odkaz:
https://doaj.org/article/bb309bed03be41bc8ba69a65e7023ec7
Publikováno v:
Journal of Lipids, Vol 2013 (2013)
Experiments were performed in 3T3-L1 preadipocytes differentiated in vitro into adipocytes. Cells were treated with olanzapine and a 5-lipoxygenase (5-LOX) activating protein (FLAP) inhibitor MK-886. Lipid content was measured using an Oil Red O assa
Externí odkaz:
https://doaj.org/article/1f4eca8d08d64f78ba1dc688c1ce287a
Publikováno v:
Neural Plasticity, Vol 2009 (2009)
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. We used methylation-sensitive restriction endonucleases (AciI, BstUI, HpaII, and HinP1I) to assess 5-LOX DNA methylation i
Externí odkaz:
https://doaj.org/article/31fdce3c64504583bfd834470b53ee43
Publikováno v:
BioMolecular Concepts. 3:107-115
Neuroepigenetics, which includes nuclear DNA modifications, such as 5-methylcytosine and 5-hydroxymethylcytosine and modifications of nuclear proteins, such as histones, is emerging as the leading field in molecular neuroscience. Historically, a func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9385f37f01ee56d974994d856fece90b
https://doi.org/10.1515/bmc-2011-0058
https://doi.org/10.1515/bmc-2011-0058
Publikováno v:
Restorative Neurology and Neuroscience. 30:237-245
Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8286cce54fe3c2937a477750df64c5b4
https://doi.org/10.3233/rnn-2012-110223
https://doi.org/10.3233/rnn-2012-110223
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 35:315-319
Typically, cyclooxygenases (COXs) and 5-lipoxygenase (5-LOX), enzymes that generate biologically active lipid molecules termed eicosanoids, are considered inflammatory. Hence, their putative role in Alzheimer's disease (AD) has been explored in the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a916e0f91ea1718e598210a06e0066d7
https://doi.org/10.1016/j.pnpbp.2010.07.032
https://doi.org/10.1016/j.pnpbp.2010.07.032
Publikováno v:
Neuroscience. 171:383-389
It has been suggested that the enzymatic pathway of 5-lipoxygenase (5-LOX) influences brain functioning and pathobiology. The mRNAs for both the enzyme 5-LOX and its activating protein FLAP have been found in the cerebellum. In this work, we investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c9b9c1d6f7c370fbcbe5675963736f
https://doi.org/10.1016/j.neuroscience.2010.09.019
https://doi.org/10.1016/j.neuroscience.2010.09.019
Publikováno v:
Neuroscience. 164:1531-1537
5-Lipoxygenase (5-LOX), an enzyme involved in the metabolism of arachidonic acid, participates in the modulation of the proliferation and differentiation of neural stem cells and cerebellar granule cell (CGC) precursors. Since epigenetic mechanisms i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3043fbc761b225d1711837babb56b93f
https://doi.org/10.1016/j.neuroscience.2009.09.039
https://doi.org/10.1016/j.neuroscience.2009.09.039
Publikováno v:
Neuroscience Letters. 452:258-261
Growing evidence has pointed to an interaction between the tetracycline antibiotic minocycline and drugs with abuse liability such as opioids and amphetamines. In this work, we tested the hypothesis that similar to its effects on methamphetamine-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ea27d1fc0333565caa1ae80c1918f4
https://doi.org/10.1016/j.neulet.2009.01.078
https://doi.org/10.1016/j.neulet.2009.01.078
Publikováno v:
Neural Plasticity, Vol 2009 (2009)
Neural Plasticity
Neural Plasticity
The expression of 5-lipoxygenase (5-LOX) is affected by aging and regulated by epigenetic mechanisms including DNA methylation. We used methylation-sensitive restriction endonucleases (AciI, BstUI, HpaII, and HinP1I) to assess 5-LOX DNA methylation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06ce91eaf7032d75332c74b0b2f8c1b
https://doi.org/10.1155/2009/209596
https://doi.org/10.1155/2009/209596