Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hari Krishna Santhapuram"'
Autor:
Joseph A. Reddy, Melissa Nelson, Christina Dircksen, Marilynn Vetzel, Theresa Johnson, Vicky Cross, Elaine Westrick, LongWu Qi, Spencer Hahn, Hari Krishna Santhapuram, Garth Parham, Kevin Wang, Jeremy F. Vaughn, Albert Felten, Michael Pugh, June Lu, Patrick Klein, Iontcho R. Vlahov, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDC
Externí odkaz:
https://doaj.org/article/62cffd133d60412fb62fcc23f334889b
Autor:
Iontcho Radoslavov Vlahov, Garth L. Parham, Patrick J. Klein, Elaine Westrick, June Lu, Christopher P. Leamon, Christina Dircksen, Marilynn Vetzel, Jeremy F. Vaughn, Albert Felten, Melissa Nelson, Vicky A. Cross, Longwu Qi, Kevin Wang, Hari Krishna Santhapuram, Joseph A. Reddy, Theresa Johnson, Spencer Hahn, Michael Pugh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with va
Autor:
Jeff Nicoson, Kevin Wang, Fei You, Hanna F. Klein, Longwu Qi, Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Hari Krishna Santhapuram, Joe Reddy, Dan Reno, Garth L. Parham, Paul J. Kleindl, Spencer Hahn, Ning Zou, Christopher P. Leamon, Albert Felten
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(7)
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone t
Autor:
Marilynn Vetzel, Hari Krishna Santhapuram, Christina Dircksen, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Paul J. Kleindl, Melissa Nelson, Joseph A. Reddy, Ryan Dorton, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of sp
Autor:
Jeremy F. Vaughn, Joseph A. Reddy, Hari Krishna Santhapuram, Fei You, Hanna F. Klein, Melissa Nelson, Albert Felten, Longwu Qi, Paul J. Kleindl, Christopher P. Leamon, Iontcho Radoslavov Vlahov, Jeff Nicoson, Spencer Hahn, Marilynn Vetzel, Kevin Wang, Garth L. Parham
Publikováno v:
Bioconjugate Chemistry. 28:2921-2931
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone
Autor:
Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Kevin Wang, Philip S. Low, Hari Krishna Santhapuram, Patrick J. Klein, Elaine Westrick, Fei You, Yingjuan Lu, Christopher P. Leamon, Mark A Gehrke, Torian W. Stinnette, Paul J. Kleindl, Kristin N. Wollak, Nikki Parker, Spencer Hahn, Vicky A. Cross
Publikováno v:
Molecular Medicine. 21:584-596
Folate receptor (FR)-β has been identified as a promising target for antimacrophage and antiinflammatory therapies. In the present study, we investigated EC0565, a folic acid-derivative of everolimus, as a FR-specific inhibitor of the mammalian targ
Autor:
Elaine Westrick, Ryan Dorton, Hari Krishna Santhapuram, Jeremy F. Vaughn, Melissa Nelson, Paul J. Kleindl, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Joseph A. Reddy, Fei You, Marilynn Vetzel, Christopher P. Leamon
Publikováno v:
Bioconjugate Chemistry. 25:560-568
Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology studies. Structurally, vintafolide consists of 4 essential modules: (1) folic acid, (2) a hydro
Autor:
Hari Krishna Santhapuram, Jeremy F. Vaughn, Kevin K.W. Wang, Iontcho Radoslavov Vlahov, Melissa Nelson, Christopher P. Leamon, Longwu Qi, Joseph A. Reddy, Spencer Hahn, Garth L. Parham, Marilynn Vetzel
Publikováno v:
Cancer Research. 79:216-216
Naturally occurring pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a group of highly potent antitumor antibiotics, isolated from various streptomycin species. PBDs covalently bond and cross-link with discrete sequences of base pairs in the minor groov
Autor:
Albert Felten, Hari Krishna Santhapuram, Spencer Hahn, Ning Zou, Christopher P. Leamon, Kevin K.W. Wang, Jeremy F. Vaughn, Paul J. Kleindl, Iontcho Radoslavov Vlahov
Publikováno v:
Cancer Research. 78:757-757
Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antibiotics are a class of natural products produced by various actinomycetes bacteria. PBD-dimers function as sequence-selective DNA-crosslinking, alkylating compounds which are considerably more potent than s
Autor:
Elaine Westrick, Leroy W. Wheeler, Hari Krishna Santhapuram, Joseph A. Reddy, Iontcho Radoslavov Vlahov, Albert Felten, Christopher P. Leamon, Melissa Nelson, Le-Cun Xu, Marilynn Vetzel
Publikováno v:
Cancer Research. 78:852-852
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer as well as on the neovasculature of many non-prostate solid tumors. Lately, several small molecular PSMA binding ligands chelated to various radionuclid