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Autor:
Harold G. Selnick, Nathaniel L. Elsen, Sangita B. Patel, Dawn L. Hall, John C. Reid, Fred Hess, Maria Kornienko, Hari Kandula, Daniel J. Klein, Rachael E. Ford, Sujata Sharma, Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman
Publikováno v:
Nature chemical biology. 13(6)
O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displa