Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hari Kamadurai"'
Autor:
Jason J Early, Katy LH Marshall-Phelps, Jill M Williamson, Matthew Swire, Hari Kamadurai, Marc Muskavitch, David A Lyons
Publikováno v:
eLife, Vol 7 (2018)
Myelinating oligodendrocytes are essential for central nervous system (CNS) formation and function. Their disruption is implicated in numerous neurodevelopmental, neuropsychiatric and neurodegenerative disorders. However, recent studies have indicate
Externí odkaz:
https://doaj.org/article/64c2a06001304f82961b269951745d76
Autor:
Alfredo Csibi, Nello Mainolfi, Veronica Campbell, Bin Yang, Mike Sintchak, Michele Mayo, Sharon Townson, Sean Zhu, Haojing Rong, Hari Kamadurai, Henry Li, Phillip Liu, Anthony Slavin, Karen Yuan, Scott F. Rusin, Kirti Sharma, Chris De Savi, Nan Ji, Jared Gollob, Yogesh Chutake, Duncan Walker, Alice McDonald
Publikováno v:
Cancer Research. 80:LB-088
Signal transducer and activator of transcription 3 (STAT3) has been implicated in multiple aspects of tumorigenesis. In addition to increasing cancer cell proliferation and survival, constitutively activated STAT3 is proposed to regulate cross-talk b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf55692bc7b3ca0baadf1d0b2f5d6458
https://doi.org/10.1158/1538-7445.am2020-lb-088
https://doi.org/10.1158/1538-7445.am2020-lb-088
Autor:
Michele Mayo, Duncan Walker, Scott F. Rusin, Kirti Sharma, Hari Kamadurai, Christine Loh, Nello Mainolfi, Fred Csibi, Karen Yuan, Nan Ji, Bin Yang, Jared Gollob, Haojing Rong, Jesse Chen, Sharon Townson, Henry Li
Publikováno v:
Molecular Cancer Therapeutics. 18:C054-C054
Purpose: Targeted protein degradation is a novel therapeutic modality that holds the promise to target previously “undruggable” proteins by harnessing the innate ubiquitin proteasome system in cells. In this study we describe the discovery and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac89c4e8ce98f4e8acbc1d344f2730e1
https://doi.org/10.1158/1535-7163.targ-19-c054
https://doi.org/10.1158/1535-7163.targ-19-c054
Autor:
Jill M Williamson, Matthew Swire, Marc A. T. Muskavitch, David A. Lyons, Hari Kamadurai, Katy L. H. Cole, Jason J Early
Publikováno v:
eLife, Vol 7 (2018)
Early, J J, Cole, K LH, Williamson, J M, Swire, M, Kamadurai, H, Muskavitch, M & Lyons, D A 2018, ' An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination ', eLIFE, vol. 7, e35136 . https://doi.org/10.7554/eLife.35136
eLife
Early, J J, Cole, K LH, Williamson, J M, Swire, M, Kamadurai, H, Muskavitch, M & Lyons, D A 2018, ' An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination ', eLIFE, vol. 7, e35136 . https://doi.org/10.7554/eLife.35136
eLife
Myelinating oligodendrocytes are essential for central nervous system (CNS) formation and function. Their disruption is implicated in numerous neurodevelopmental, neuropsychiatric and neurodegenerative disorders. However, recent studies have indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0350d872b700569579c4737655fb94d2
https://elifesciences.org/articles/35136
https://elifesciences.org/articles/35136
Autor:
Michele Mayo, Scott F. Rusin, Christine Loh, Jesse Chen, Bin Yang, Kirti Sharma, Sharon Townson, Karen Yuan, Nan Ji, Jared Gollob, Duncan Walker, Nello Mainolfi, Henry Li, Fred Csibi, Haojing Rong, Hari Kamadurai
Publikováno v:
Blood. 134:3803-3803
Targeted protein degradation mediated by small molecule degraders represents a new and exciting therapeutic modality to target difficult-to-drug oncogenic proteins including transcription factors. These molecules bind to both the target protein and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8427c09ff7e8ed06f470875a57bcd9dd
https://doi.org/10.1182/blood-2019-128981
https://doi.org/10.1182/blood-2019-128981
Autor:
Dominico Vigil, Laurent P. Audoly, Duncan Walker, Hari Kamadurai, Christine Loh, Jesse Chen, Yi Zhang, Alice McDonald, Veronica Campbell, Joseph Kelleher, Henry Li, Karen Yuan, Nan Ji, Haojing Rong, Nello Mainolfi, Kirti Sharma, Jared Gollob, Matthew J. Weiss, Christine Klaus, Scott F. Rusin
Publikováno v:
Cancer Research. 79:LB-272
Purpose: This work assessed the antitumor activity of selective small molecule IRAK4 degraders in human ABC DLBCL cell lines in vitro and in tumor xenograft models in vivo, alone and in combination with BTK inhibition. Introduction: ABC DLBCL compris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45be78933cdc85739100dea1a299b92
https://doi.org/10.1158/1538-7445.am2019-lb-272
https://doi.org/10.1158/1538-7445.am2019-lb-272
Autor:
Duncan Walker, Y. Zhang, Kirti Sharma, C. Loh, N. Ji, H. Li, Christine Klaus, J. Chen, H. Rong, Scott F. Rusin, J. Kelleher, Hari Kamadurai, Nello Mainolfi, D. Vigil, K. Yuan, V. Campbell, Jared Gollob, Michael Weiss, Alice McDonald
Publikováno v:
Hematological Oncology. 37:129-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a89ec011f5487c29c2f92ba8af956
https://doi.org/10.1002/hon.89_2629
https://doi.org/10.1002/hon.89_2629
Autor:
Hari Kamadurai, Mark Foster
Publikováno v:
Biochemistry. 46:13939-13947
Bacteriophage lambda integrase (lambda-Int), a phage-encoded DNA recombinase, cleaves its substrate DNA to facilitate the formation and later resolution of a Holliday junction intermediate during recombination. The core-binding and catalytic domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f613b1d0ed6886f6bfccce060c2d6500
https://doi.org/10.1021/bi700974t
https://doi.org/10.1021/bi700974t
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