Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Autor: Papa, Feroz, Oakes, Scott, Wang, L, Perera, BGK, Hari, SB, Bhhatarai, B, Backes, BJ, Seeliger, MA, Schürer, SC, Oakes, SA, Papa, FR, Maly, DJ

Publikováno v: Papa, Feroz; Oakes, Scott; Wang, L; Perera, BGK; Hari, SB; Bhhatarai, B; et al.(2012). Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/35m2c219

Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase/endoRNase (RNase) IRE1α. IRE1α oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c8aa756f8712ba1353b09419aee104ab
http://www.escholarship.org/uc/item/35m2c219

Fluoroscopically Guided vs Landmark-Guided Sacroiliac Joint Injections: A Randomized Controlled Study.

Autor: Cohen SP; Department of Anesthesiology, and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD; Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD; Department of Anesthesiology, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD; Department of Physical Medicine and Rehabilitation, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD. Electronic address: scohen40@jhmi.edu., Bicket MC; Department of Anesthesiology, and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD., Kurihara C; Pain Medicine Service, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD., Griffith SR; Department of Anesthesiology, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD; Pain Medicine Service, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD., Fowler IM; Department of Anesthesiology, Naval Medical Center-San Diego, CA., Jacobs MB; Department of Physical Medicine and Rehabilitation, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD., Liu R; Department of Anesthesiology, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD., Anderson White M; Department of Anesthesiology, and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD; Department of Anesthesiology, Johns Hopkins Medical Institutions, Baltimore, MD., Verdun AJ; Pain Medicine Service, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD., Hari SB; Department of Anesthesiology, Naval Hospital-Okinawa, Japan., Fisher RL; Department of Anesthesiology, Naval Medical Center-San Diego, CA., Pasquina PF; Department of Physical Medicine and Rehabilitation, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD; Center for Rehabilitation Sciences Research, Bethesda, MD., Vorobeychik Y; Department of Anesthesiology and Department of Neurology, Penn State-Hershey Medical Center, PA.

Publikováno v: Mayo Clinic proceedings [Mayo Clin Proc] 2019 Apr; Vol. 94 (4), pp. 628-642. Date of Electronic Publication: 2019 Mar 08.

Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase.

Autor: Hari SB; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Grant RA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sauer RT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: bobsauer@mit.edu.

Publikováno v: Structure (London, England : 1993) [Structure] 2018 Sep 04; Vol. 26 (9), pp. 1251-1258.e3. Date of Electronic Publication: 2018 Jul 26.

The AAA+ FtsH Protease Degrades an ssrA-Tagged Model Protein in the Inner Membrane of Escherichia coli.

Autor: Hari SB; Department of Biology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States., Sauer RT; Department of Biology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

Publikováno v: Biochemistry [Biochemistry] 2016 Oct 11; Vol. 55 (40), pp. 5649-5652. Date of Electronic Publication: 2016 Sep 30.

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Autor: Ghosh R; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Wang L; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Wang ES; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA., Perera BG; Department of Chemistry, University of Washington, Seattle, WA 98195, USA., Igbaria A; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Morita S; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Prado K; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Thamsen M; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Caswell D; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA., Macias H; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA., Weiberth KF; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Gliedt MJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA., Alavi MV; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA., Hari SB; Department of Chemistry, University of Washington, Seattle, WA 98195, USA., Mitra AK; Department of Chemistry, University of Washington, Seattle, WA 98195, USA., Bhhatarai B; Department of Molecular and Cellular Pharmacology,, Miller School of Medicine, University of Miami, FL 33136, USA., Schürer SC; Center for Computational Science, Miller School of Medicine, University of Miami, FL 33136, USA; Department of Molecular and Cellular Pharmacology,, Miller School of Medicine, University of Miami, FL 33136, USA., Snapp EL; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Gould DB; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA., German MS; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA., Backes BJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA., Maly DJ; Department of Chemistry, University of Washington, Seattle, WA 98195, USA., Oakes SA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: scott.oakes@ucsf.edu., Papa FR; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: frpapa@medicine.ucsf.edu.

Publikováno v: Cell [Cell] 2014 Jul 31; Vol. 158 (3), pp. 534-48. Date of Electronic Publication: 2014 Jul 10.